A new case of allergic contact dermatitis caused by 3‐o‐ethyl ascorbic acid in facial antiageing cosmetics

PEG‐45/dodecyl glycol co‐polymer and bis‐diglyceryl polyacyladipate‐2: Two culprits responsible of an allergic contact dermatitis to a lip balm

“…The present observation also emphasizes the value of performing a ROAT with suspected ingredients when investigating a possible allergic contact dermatitis to cosmetics 9 . In our patient, ROATs with two ingredients contained in the suspected product proved clearly positive, whereas patch tests with the same ingredients, diluted at the concentration and in the vehicle used in the commercial product, were first only doubtful on D4.…”

A rare case of allergic contact dermatitis caused by 3‐O‐ethyl‐L‐ascorbic acid in skin‐whitening cosmetics identified under immunosuppressive therapy

“…Besides our case, there are only five previous cases of allergic contact dermatitis caused by 3‐O‐ethyl‐L‐ascorbic acid, 2‐6 all of them associated with skin‐whitening cosmetics. Most notable in our case, we were able to identify the patient's allergen by use of patch testing, although she had been treated with methotrexate and etanercept.…”

Allergic contact dermatitis to two eye creams containing tetrahexyldecyl ascorbate

“…In another early case, oral exposure to ascorbic acid elicited dermatitis ~20 hours after ingestion and also a positive reaction on patch testing 2 . Other reported cases of topical vitamin C allergy include 3‐glyceryl ascorbate in a skin‐lightening lotion, 3 3‐ o ‐ethyl‐L‐ascorbic acid in several patients 4‐7 and two reported cases of ACD to ascorbyl tetraisopalmitate 8,9 . In several of these reports, other vitamin C derivatives were also tested, and all results were negative, suggesting that ACD in response to vitamin C derivatives may be specific.…”