A new carbon paste electrode modified with MWCNTs and nano-structured molecularly imprinted polymer for ultratrace determination of trimipramine: The crucial effect of electrode components mixing on its performance

Akhoundian, Maedeh; Alizadeh, Taher; Ganjali, Mohammad Reza; Rafiei, Faride

doi:10.1016/j.bios.2018.03.061

Cited by 45 publications

(20 citation statements)

References 27 publications

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“…al. [143] used SWV to measure trace levels of the antidepressant trimipramine in pharmaceutical formulations, urine and serum. A MWCNT and MIP NP combination modified CPE was used, and the drug was shown to undergo a three electron transfer with oxidation O 1 due to a two‐electron, one proton irreversible oxidation of a free radical and R 2 /O 2 redox peaks due to reversible one electron and one proton oxidation and reduction of a dimer.…”

Section: Mip Based Voltammetric Sensorsmentioning

confidence: 99%

Molecular Imprinted Polymer Modified Electrochemical Sensors for Small Drug Analysis: Progress to Practical Application

Feroz

Vadgama

2020

Electroanalysis

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Molecular imprinted polymers (MIPs) are tailor made from synthetic polymers and designed to mimic the recognition properties of natural biological affinity molecules. MIPs incorporate binding motifs complementary to target organic molecule shape and functional groups in order to mimic the complex binding surfaces of natural macromolecules. This confers selectivity and specificity, with the added advantage of artificial MIP polymer stability and ready adaptability to the fabrication and creation of miniaturised affinity interfaces for electrochemical sensing and extra‐laboratory testing. Their generic capability as robust sorbent phases for drug extraction and concentration allows for targeted, interfacial interrogation by the active electrochemical surface. A wide range of electrochemical sensing strategies has also been advanced in recent years, which is covered by this review. The review covers MIP functional principles, examples of MIP preparative routes and final assay outcomes for the measurement of small molecule drugs of biomedical, and also of potential environmental relevance. Some small molecules as examples of toxin and contaminant measurement are also given. A historic background to MIP development is provided, but the review mainly focuses on electrochemical sensor advances in the last five years.

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Section: Mip Based Voltammetric Sensorsmentioning

confidence: 99%

Molecular Imprinted Polymer Modified Electrochemical Sensors for Small Drug Analysis: Progress to Practical Application

Feroz

Vadgama

2020

Electroanalysis

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“…Another application on coupling MWCNTs with MIPs was reported recently by Akhoundian et al. for tripiramine (TRI) detection. This sensing system consit on a carbon nanocomposite paste electrode embeded with embeded MIPs nanoparticles and MWCNTS.…”

Section: Nanomaterials Combined Mip Based Electrochemical Sensorsmentioning

confidence: 99%

Recent Advances in Electrochemical Sensors Based on Molecularly Imprinted Polymers and Nanomaterials

2018

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This review focuses on the recent achievement during period of 2013–2018 related to the electrochemical sensors based on molecularly imprinted polymers (MIPs) combined with nanomaterials for various kinds of applications. MIPs based electrochemical sensors have found a great interest due to their high stability, short time required for electropolymerization, and high specificity towards the target analyte. The sensitivity is considered as one of the important parameter in electrochemical sensing strategies that should be improved by the combination of highly conductive nanomaterials with selective MIPs. In general, the most employed nanomaterials are magnetic nanoparticles, gold nanoparticles (AuNPs), carbon nanotubes and graphene. This review discusses the main current achievement as well as the current challenges regarding the development of biomimetic sensors in electroanalysis.

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“…CPE has triggered great interest as sensing substrate. This can be attributed to its simplicity in preparation, easy surface renewability, biocompatibility and most of all, easy amenability for modification with low background current [13][14][15]. Owing to many documented advantages, CNTs are still being widely used as probes in designing modified electrodes [16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

S(O)MWCNT/modified Carbon Paste – A Non‐enzymatic Amperometric Sensor for Direct Determination of 6‐Mercaptopurine in Biological Fluids

Manasa¹,

Raj²,

Satpati

et al. 2020

Electroanalysis

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In this study, carbon paste electrode (CPE) modified with strongly oxidized MWCNT (S(O)MWCNT) was developed as an efficient, economical, electrochemical sensor for the detection of 6‐mercaptopurine (6MP) with antineoplastic and immunosuppressive activities. However, this cytotoxic anticancer drug is associated with adverse side‐effects; hence 6MP determination becomes crucial. Drop‐cast‐coating was an effective strategy in the fabrication of S(O)MWCNT/MCPE to increase surface area. Electrochemical measurements were performed using cyclic voltammetry (CV) and amperometry. Electrochemical Impedance Spectroscopy (EIS), Field Emission Scanning Electron Microscopy (FESEM) and Energy Dispersive X‐ray (EDX) elucidated surface characteristics. With S(O)MWCNT's good conductive ability, we achieved rapid electron transfer that amplified 6MP anodic signal by 3.8 folds higher compared to bare CPE. Additionally, great consonance between CPE loaded with S(O)MWCNT yielded superior current response with decreased activation energy compared to S(O)MWCNT/modified glassy carbon electrode (S(O)MWCNT/MGCE). Under optimal conditions S(O)MWCNT/MCPE displayed a wide‐single‐linearity range from 1.0 to 100.0 μM with an excellent detection limit of 0.24 μM during amperometric quantification for the first time. It also exhibited good selectivity, after a series of common physiological interferents’ assessment. As a part of proof‐of‐concept, the proposed sensor was investigated in 6MP fortified human fluids, and the satisfactory recoveries obtained authenticated S(O)MWCNT/MCPE's accuracy and reliability for practical applicability.

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A new carbon paste electrode modified with MWCNTs and nano-structured molecularly imprinted polymer for ultratrace determination of trimipramine: The crucial effect of electrode components mixing on its performance

Cited by 45 publications

References 27 publications

Molecular Imprinted Polymer Modified Electrochemical Sensors for Small Drug Analysis: Progress to Practical Application

Molecular Imprinted Polymer Modified Electrochemical Sensors for Small Drug Analysis: Progress to Practical Application

Recent Advances in Electrochemical Sensors Based on Molecularly Imprinted Polymers and Nanomaterials

S(O)MWCNT/modified Carbon Paste – A Non‐enzymatic Amperometric Sensor for Direct Determination of 6‐Mercaptopurine in Biological Fluids

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