A new cancer hypothesis

Zajicek, G.

doi:10.1016/s0306-9877(96)90449-1

Cited by 7 publications

(6 citation statements)

References 6 publications

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“…Despite their obvious differences and with few exceptions [14], most theories about cancer proposed during the last century share a common denominator: cancer is believed to be a biological nonsense for the organism in which it originates, since cancer cells are believed to be ones that evade the rules controlling normal cell proliferation and differentiation. According to that understanding, cancer cells have usually been considered as cells returning to a more primitive, unicellular, condition of life.…”

Section: Resultsmentioning

confidence: 99%

The biological sense of cancer: a hypothesis

Ruggiero

Bustuoabad

2006

Theor Biol Med Model

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Background: Most theories about cancer proposed during the last century share a common denominator: cancer is believed to be a biological nonsense for the organism in which it originates, since cancer cells are believed to be ones evading the rules that control normal cell proliferation and differentiation. In this essay, we have challenged this interpretation on the basis that, throughout the animal kingdom, cancer seems to arise only in injured organs and tissues that display lost or diminished regenerative ability.

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Section: Resultsmentioning

confidence: 99%

The biological sense of cancer: a hypothesis

Ruggiero

Bustuoabad

2006

Theor Biol Med Model

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“…"The exacerbations and remissions will be indicated by the diseases, the seasons of the year, the reciprocation of the periods, whether they occur every day, every alternate day, or after a longer period, and by the supervening symptoms" (Hippocrates) [11]. An important breakthrough in cancer biology was the recognition of tumors as abnormal organs acting in the context of an entire organism [12][13][14][15][16][17]. Tumor metabolism is not necessarily autonomous or self-perpetuating.…”

Section: 1mentioning

confidence: 99%

Lessons from Hippocrates: Time to Change the Cancer Paradigm

Galmarini

2020

International Journal of Chronic Diseases

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The ultimate goal of all medical activity is to restore patients to a state of complete physical, mental, and social wellbeing. In cancer, it is assumed that this can only be obtained through the complete eradication of the tumor burden. So far, this strategy has led to a substantial improvement in cancer survival rates. Despite this, more than 9 million people die from cancer every year. Therefore, we need to accept that our current cancer treatment paradigm is obsolete and must be changed. The new paradigm should reflect that cancer is a systemic disease, which affects an individual patient living in a particular social reality, rather than an invading organism or a mere cluster of mutated cells that need to be eradicated. This Hippocratic holistic view will ultimately lead to an improvement in health and wellbeing in cancer patients. They deserve nothing less.

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“…It follows that the mechanism of transformation into embryonal development can be started without any carcinogenic influence. Carcinogenesis only accelerates the process of compensation of a critical level of metabolic tissue deficit [25][26][27]. It may be, therefore, expected that a revitalization of a particular tissue may be triggered into a developmental condition without dedifferentiation by the normal genome of an aging tissue.…”

Section: Cell Transformation and Cancer Developmentmentioning

confidence: 99%

Aging and Carcinogenesis – Insufficient Metabolic Cell Repair as the Common Link

Baramiya¹

2000

Gerontology

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Background: The mechanisms of the development of cancer in old age and also the mechanisms of aging are not well understood. This paper tries to interpret consequences of malignant tissue transformation from the viewpoint of aging, or in other words, from an insufficient cell adaptation to the needs of repair and proliferation. Subject: A hypothesis is presented that a unified but quite opposite at different stages of ontogenesis mechanism is the basis of atypical growth and embryonic development. In the beginning of a malignant dedifferentiation is an insufficiency of an effective self-renovation and disturbed preservation of its adaptation capability. The suppression of regenerating cell proliferation is the primary event of the development of a dedifferentiated tissue growth. The transformation of normal cells into tumor cells is an adaptive reaction in reply to a shortage of self-regeneration capability and repair. Allowing for the process of rebirth, i.e. the complete restoration of tissues leading to the restrain of senescence proceeds by the type of embryonic growth of tissues, the possibility to use the potential of transformed cells for restraining senescence is proposed. The latter will permit to direct the process of transformation to an integrated growth channel, to prevent the clinical phenomenon of malignancy, and use the potential of transformed cells for realization of the self-renovation program and program of unlimited life duration of the whole organism. Conclusion: By a stimulation or compensation of the age-induced shortage of cell metabolism, two effects can be expected: prevention of cancer and retardation of aging.

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A new cancer hypothesis

Cited by 7 publications

References 6 publications

The biological sense of cancer: a hypothesis

The biological sense of cancer: a hypothesis

Lessons from Hippocrates: Time to Change the Cancer Paradigm

Aging and Carcinogenesis – Insufficient Metabolic Cell Repair as the Common Link

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