A new biocompatible nanoparticle delivery system for the release of fibrinolytic drugs

Piras, Anna Maria; Chiellini, Federica; Fiumi, C.; Bartoli, Cristina; Chiellini, Emo; Fiorentino, Bruno; Farina, Claudio

doi:10.1016/j.ijpharm.2008.01.035

Cited by 45 publications

(27 citation statements)

References 34 publications

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“…This is particularly so in regard to formulation of nanoparticles for controlled and targeted release of nonconventional drugs and bioactive agents. [11] …”

Section: Resultsmentioning

confidence: 99%

“…The bioconjugation with anti-fibrin Fab fragment was studied with a view to exploiting the investigated material for development of nanoparticles for controlled and targeted delivery of thrombolytic agents to fibrin clots, as reported elsewhere. [11] Due to the non-biodegradable/bioresorbable nature of polymer backbone, the application of a chain transfer agent in the synthesis of poly[(maleic anhydride)-alt-(butylvinyl ether)]s was investigated to finely tune copolymer molecular weights under the renal excretion threshold.…”

Section: Full Papermentioning

confidence: 99%

“…Bioerodible polymers, either VAM41-S7 or VAM41-PEG, were biofunctionalized with the monoclonal antibody Fab fragment specific for human fibrin, the selected target in a forthcoming article regarding the development of bioerodible nanoparticles for the targeted and controlled release of fibrinolytic protein drugs to the thrombus. [11] The unreacted material was removed by dialysis and the final bioconjugated polymers were recovered by freezedrying. The average yields of the first and second steps were 85% and 95%, respectively.…”

Section: Polymer Synthesis and Modificationmentioning

confidence: 99%

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Bioactive Polymeric Materials for Targeted Administration of Active Agents: Synthesis and Evaluation

Chiellini

Piras

Gazzarri

et al. 2008

Macromolecular Bioscience

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Bioerodible polymers displaying both stealth and targeting properties for the preparation of nanosystems for targeted and controlled delivery of fibrinolytic drugs to the thrombus were prepared by straightforward synthetic routes and characterized. Poly[(maleic anhydride)-alt-(butylvinyl ether)]s were synthesized in the presence of dodecyl mercaptan as chain transfer agent allowing for the preparation of copolymers with tunable molecular weight. 2-Methoxyethanol hemiesters containing antiopsonizing molecules of poly(ethylene glycol) were prepared and further biofunctionalized with a Fab fragment by a two-step reaction. In vitro biocompatibility investigation of the prepared materials supported their suitability for biomedical applications.

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“…This is particularly so in regard to formulation of nanoparticles for controlled and targeted release of nonconventional drugs and bioactive agents. [11] …”

Section: Resultsmentioning

confidence: 99%

Section: Full Papermentioning

confidence: 99%

Section: Polymer Synthesis and Modificationmentioning

confidence: 99%

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Bioactive Polymeric Materials for Targeted Administration of Active Agents: Synthesis and Evaluation

Chiellini

Piras

Gazzarri

et al. 2008

Macromolecular Bioscience

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“…The development of biocompatible polymer materials is important in various life science, medical, and pharmaceutical fields [1][2][3][4]. Optical biofilm has been studied for ophthalmic applications, including spectacle lenses, contact lenses, and intraocular lenses [5,6].…”

Section: Introductionmentioning

confidence: 99%

Applications of ophthalmic biomaterials embedded with fucoidan

Lee

Kim

Cho

2012

Journal of Industrial and Engineering Chemistry

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“…[1][2][3][4][5] In particular, hydrogels occupies an important portion among biomaterials due to their hydrophilicity and ability to absorb water without losing their viscoelasticity. 6 Swelling behavior, mechanical properties, and biocompatiblility of the hydrogels should be evaluated for use of biomedical purposes.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Hydrogel Contact Lens Containing Alginate

Lee¹,

Kim²,

Cho

2011

Bulletin of the Korean Chemical Society

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Biocompatible hydrogels from 2-hydroxyethyl methacrylate (HEMA) monomer containing various amount of alginate in the presence and absence of hydrophilic methacrylic acid (MAA) were synthesized in order for biomedical application. The antimicrobial effect and interaction with proteins for hydrogels were investigated in this study. MAA was introduced because it was expected to increase the amount of water content in the polymer which is an important factor for biocompatibility, and alginate was expected to enhance the antimicrobial activity. The antimicrobial effect against S. aureus and E. coli increased for all hydrogels as the amount of alginate and MAA contained. Presence of MAA further enhances the antimicrobial effect. Amount of adsorption of bovine serum albumin (BSA) increased with increasing concentration of alginate whether MAA was present or not. Contrarily, the amount of lysozyme was not affected with increasing alginate concentration in the absence of MAA, while it decreased in the presence of MAA.

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A new biocompatible nanoparticle delivery system for the release of fibrinolytic drugs

Cited by 45 publications

References 34 publications

Bioactive Polymeric Materials for Targeted Administration of Active Agents: Synthesis and Evaluation

Bioactive Polymeric Materials for Targeted Administration of Active Agents: Synthesis and Evaluation

Applications of ophthalmic biomaterials embedded with fucoidan

Antimicrobial Hydrogel Contact Lens Containing Alginate

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