A new approach to select solvents and operating conditions for supercritical antisolvent precipitation processes by using solubility parameter and group contribution methods

Coprecipitation of curcumin/PVP with enhanced dissolution properties by the supercritical antisolvent process

“…In the SAS process, the selection of the operational conditions is crucial in the success of the precipitation [46,47]. Knowledge of thermodynamics, jet hydrodynamics, mass transfer and crystallization kinetics is required to properly understand the results.…”

Screening design of experiment applied to the supercritical antisolvent precipitation of quercetin

“…Reverchon et al [37] found out the same trend when temperature was increased to 60 • C. It was expected that lower temperature would favor the expansion of solvent but it seems that quercetin has an influence on the antisolvent process. In this way Pereira et al [38] studied the antisolvent operating conditions in several ternary mixtures of drug-solvent and CO 2 and concluded that higher temperatures were better to the antisolvent process due to the greater differences in solubility parameters between drug-solvent and CO 2 -solvent. However, positive results were not obtained at the lowest pressure and the highest temperature assayed because the operating conditions are below the MCP.…”

Recrystallizing Primidone through Supercritical Antisolvent Precipitation

“…As indicated in the predicted VLE of CO 2 + DMAC in Figure c, a CO 2 flow rate decrease or solution flow rate increase shifts the CO 2 mole fraction in the precipitator from 0.98 to 0.94. According to previous studies, ,,,− a high CO 2 mole fraction in the precipitator favors the production of small crystals. Thus, in this study, small primidone crystals were produced at a high CO 2 flow rate and a low solution flow rate (Figure c,d).…”

“…In recent years, supercritical fluid technology has been widely used in various applications. Many studies have used supercritical fluids for recrystallization of pharmaceutical compounds because of their numerous advantages. − Several supercritical fluid crystallization processes have been developed on the basis of the solubility of APIs in supercritical fluids. These techniques include rapid expansion of supercritical solution, supercritical antisolvent precipitation (SAS), supercritical-assisted atomization, and particle from gas-saturated solution. , SAS is most commonly used for processing of pharmaceutical compounds.…”