A new approach to plastic deformation of biodegradable zinc alloy with magnesium and its effect on microstructure and mechanical properties

Jarzębska, Anna; Bieda, M.; Kawałko, Jakub; Rogal, Łukasz; Koprowski, P.; Sztwiertnia, K.; Pachla, W.; Kulczyk, Mariusz

doi:10.1016/j.matlet.2017.09.090

Cited by 72 publications

(38 citation statements)

References 13 publications

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“…Development of binary Zn alloys continued with notable works by Zheng and co-workers [87,88] on Zn-Mg, as well as zinc-calcium (Zn-Ca), and zincstrontium (Zn-Sr) alloys. Other reports on Zn-Mg include those by Kubasek et al [55,89,90], Yao et al [91],Gong et al [92], Murni et al [93], Shen et al [94], Galib and Sharif [95], Mostaed et al [96], Jablonska et al [97], Dambatta et al [98,99], Vida et al [100], Jarzebska et al [101], Jin et al [102], Xiao et al [103], Alves et al [104], Wang et al [105], and Yang et al [78]. The range of Mg addition typically ranged from 1 to 3 wt%; though relatively high (>5%) [90] and low (<0.1 wt%) [102,103] alloy additions of Mg have also been reported.…”

Section: Binary Alloysmentioning

confidence: 99%

“…Jarzebska et al [101] produced 5 mm diameter Zn rods using cold hydrostatic extrusion, a type of extrusion where the billet is circumscribed in a pressurized fluid. The fluid pressure was maintained between 470 and 500 MPa and the strain rate was set to 4-40 s À1 .…”

Section: Advanced Processing Techniquesmentioning

confidence: 99%

“…Minimizing the number of alloying elements is a logical approach since each addition of an alloying element also increases expense and adds another layer of complexity during fabrication. Another observation is that very few Zn alloys, mainly extruded Zn-Mg binary alloys [94,101,102] and some ternary alloys (i.e., Zn-Mg-Sr [115] and Zn-Mg-Mn [116], have met the mechanical property standards set for cardiovascular applications. The majority of the alloys did not meet both strength and ductility requirement; while a fair amount of alloys have exceeded the ductility requirements but did not achieve the necessary strength.…”

Section: Influence Of Alloying Elementsmentioning

confidence: 99%

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The influence of alloying and fabrication techniques on the mechanical properties, biodegradability and biocompatibility of zinc: A comprehensive review

2019

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Zinc has been identified as one of the most promising biodegradable metals along with magnesium and iron. Zinc appears to address some of the core engineering problems associated with magnesium and iron when applied to biomedical implant applications; hence the increase in the amount of research investigations on the metal in the last few years. In this review, the current state-of-the-art on biodegradable Zn, including recent developments, current opportunities and future directions of research are discussed. The discussions are presented with a specific focus on reviewing the relationships that exist between mechanical properties, biodegradability, and biocompatibility of zinc with alloying and fabrication techniques. This work hopes to guide future studies on biodegradable Zn that will help in advancing this field of research. Statement of Significance (i) The review offers an up-to-date and comprehensive review of the influence of alloying and fabrication technique on mechanical properties, biodegradability and biocompatibility of Zn; (ii) the work cites the most relevant biodegradable Zn fabrication processes including additive manufacturing techniques; (iii) the review includes a listing of research gap and future research directions for the field of biodegradable Zn.

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Section: Binary Alloysmentioning

confidence: 99%

Section: Advanced Processing Techniquesmentioning

confidence: 99%

Section: Influence Of Alloying Elementsmentioning

confidence: 99%

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The influence of alloying and fabrication techniques on the mechanical properties, biodegradability and biocompatibility of zinc: A comprehensive review

2019

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“…This includes Zn-Mg, Zn-Ca, Zn-Sr, Zn-Al-Cu alloys and pure Zn with appropriate mechanical characteristics, in particular, ultimate tensile strength (UTS) in the range of 20-440 MPa, and elongation to failure 10-65% for stent application. The influence of severe plastic deformation on the structure and mechanical characteristics of the zinc alloy with 1 wt% of Mg is presented by Jarzebska et al [145]. These results indicate that the plastic deformation leads to the grain refinement, and mechanical properties satisfy the requirements for bioresorbable stent applications.…”

Section: Zn Stentsmentioning

confidence: 93%

“…High Zn compatibility to magnetic resonance imaging is an additional advantage of this promising candidate for biodegradable stents as compared to iron-and magnesium-based stent materials. The efforts in the development of new Zn-based stent materials are only at the beginning and an increasing number of scientific groups is working on this topic [133,142,[145][146][147][148][149][150][151]. The results of the different studies related to the properties of Zn stents are summarized in Table 2.…”

Section: Zn Stentsmentioning

confidence: 99%

Recent Advances in Manufacturing Innovative Stents

et al. 2020

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Cardiovascular diseases are the most distributed cause of death worldwide. Stenting of arteries as a percutaneous transluminal angioplasty procedure became a promising minimally invasive therapy based on re-opening narrowed arteries by stent insertion. In order to improve and optimize this method, many research groups are focusing on designing new or improving existent stents. Since the beginning of the stent development in 1986, starting with bare-metal stents (BMS), these devices have been continuously enhanced by applying new materials, developing stent coatings based on inorganic and organic compounds including drugs, nanoparticles or biological components such as genes and cells, as well as adapting stent designs with different fabrication technologies. Drug eluting stents (DES) have been developed to overcome the main shortcomings of BMS or coated stents. Coatings are mainly applied to control biocompatibility, degradation rate, protein adsorption, and allow adequate endothelialization in order to ensure better clinical outcome of BMS, reducing restenosis and thrombosis. As coating materials (i) organic polymers: polyurethanes, poly(ε-caprolactone), styrene-b-isobutylene-b-styrene, polyhydroxybutyrates, poly(lactide-co-glycolide), and phosphoryl choline; (ii) biological components: vascular endothelial growth factor (VEGF) and anti-CD34 antibody and (iii) inorganic coatings: noble metals, wide class of oxides, nitrides, silicide and carbide, hydroxyapatite, diamond-like carbon, and others are used. DES were developed to reduce the tissue hyperplasia and in-stent restenosis utilizing antiproliferative substances like paclitaxel, limus (siro-, zotaro-, evero-, bio-, amphi-, tacro-limus), ABT-578, tyrphostin AGL-2043, genes, etc. The innovative solutions aim at overcoming the main limitations of the stent technology, such as in-stent restenosis and stent thrombosis, while maintaining the prime requirements on biocompatibility, biodegradability, and mechanical behavior. This paper provides an overview of the existing stent types, their functionality, materials, and manufacturing conditions demonstrating the still huge potential for the development of promising stent solutions.

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The Prospects for Biodegradable Zinc in Wound Closure Applications

Venezuela

Johnston

Dargusch

2019

Adv Healthcare Materials

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Zinc is identified as a promising biodegradable metal along with magnesium and iron. In the last five years, considerable progress has been made on understanding the mechanical properties, biodegradability, and biocompatibility of zinc and its alloys. A majority of these studies focused on using zinc for absorbable cardiovascular and orthopedic device applications. However, it is likely that zinc is also suitable for other biomedical applications.In this work, the prospects for zinc in the fabrication of wound closure devices such as absorbable sutures, staples, and surgical tacks are critically assessed, with the aim of inspiring future research on biodegradable Zn for this medical application.

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A new approach to plastic deformation of biodegradable zinc alloy with magnesium and its effect on microstructure and mechanical properties

Cited by 72 publications

References 13 publications

The influence of alloying and fabrication techniques on the mechanical properties, biodegradability and biocompatibility of zinc: A comprehensive review

The influence of alloying and fabrication techniques on the mechanical properties, biodegradability and biocompatibility of zinc: A comprehensive review

Recent Advances in Manufacturing Innovative Stents

The Prospects for Biodegradable Zinc in Wound Closure Applications

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