A “New” Antibody Anti-LuaLub and Two Further Examples of the Genotype Lu(a–b–)

Darnborough, J.; Firth, R. H.; Giles, Carolyn M.; Goldsmith, K. L. G.; Crawford, Mary N.

doi:10.1038/198796a0

Cited by 51 publications

(26 citation statements)

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“…Her surviving brother has not yet been contacted: whatever his Lutheran groups may be they cannot show whether Mrs. Di. belongs to the dominant [1] or the recessive [2] type of Lu(a-b-). If he were his sister, it wo old confirm the assumption that the inhibition is, as in other families, genetic in origin.…”

Section: Patricia Tippettmentioning

confidence: 99%

A Case of Suppressed Lu^a and Lu^b Antigens

Tippett¹

1971

Vox Sanguinis

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Section: Patricia Tippettmentioning

confidence: 99%

A Case of Suppressed Lu^a and Lu^b Antigens

Tippett¹

1971

Vox Sanguinis

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“…), which has been deduced from serological tests [8], is confirmed on a quantitative basis. The antigen recognised by BRIC-108 is also absent from the example of Lu(a-b-) cells of the X-linked type studied, which is consistent with serologi cal absorption/elution tests with this antibody.…”

Section: Methodsmentioning

confidence: 80%

“…suppressor gene In(Lu), as antibody can be absorbed onto, and eluted from, these cells although they are not agglu tinated [7], The antigen appears to be totally absent, as judged by serological tests, from cells with the recessive Lu(a-b-) phenotype [8], It has recently been reported that the Lu(a-b-) phenotype may also result from the inheri tance of an X-linked recessive gene, XS2 [9], The antigen detected by some human anti-Lua and anti-Lub sera by serological tests [10] and by the monoclonal antibody BRIC-108 by serological or immunochemical tests [3] seems to be sensitive to treatment with the proteolytic enzymes pronase and trypsin. The quantitative basis for these observations has now been examined.…”

Section: Introductionmentioning

confidence: 99%

Estimation of the Number of Binding Sites for a Murine Monoclonal Anti-Lu^b on Human Erythrocytes

Merry¹,

Gardner²,

Parsons³

et al. 1987

Vox Sanguinis

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The number of Lu^b antigen sites on the human erythrocyte membrane, as recognised by the murine monoclonal antibody BRIC-108, has been determined. The number of antibody molecules bound per cell on one example of cells of the phenotype Lu(a-b-) with recessive inheritance was an average of around 200 in replicate determinations, which probably represents non-specific antibody binding. A similar number of antibody molecules to this bound to trypsin- or pronase-treated normal cells or cells of the Lu(a-b-) phenotype associated with the inheritance of the X-borne gene, XS2. The number of binding sites on three examples of cells of the phenotype Lu(a-b-) with dominant inheritance was from 440 to 690. A variation in the number of binding sites per cell from 1,640 to 4,070 was found in five individuals with the phenotype Lu(a-b+) and from 850 to 1,820 in four individuals with the phenotype Lu(a+b+). Four individuals with the Lu(a+b-) phenotype had an average of 480 binding sites per cell. The Lu^b antigen therefore appears to a have low-site density and a variable level of expression on the erythrocyte surface.

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“…

Recent studies have described high frequency red cell antigens that are related to the Lutheran blood group [1,2]. The antigens, named Lu4, Lu5, Lu6 and Lu7, are present in almost all blood samples that are Lu Family studies have shown Lu4, Lu6, Lu7 and Lu8 to be inherited, but family studies on Lu5 were not informative.

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mentioning

confidence: 99%

“…The antigens, named Lu4, Lu5, Lu6 and Lu7, are present in almost all blood samples that are Lu(a+b-), Lu(a + b + ) or Lu(a -b + ) but are lacking in Lu(a-b-) red cells of both dominant and recessive types of inheritance. A fifth high frequency antigen Lu8, with similar characteristics, has also been recognized [6], The name antiLu3 has been proposed [1] for the antibody found in the serum of some Lu(a -b -) people, and previously called anti-LuaLub [2], This antibody is believed to be directed against a precursor from which the antigens of the Lutheran complex arise.…”

mentioning

confidence: 99%