A new anorexigenic protein, nesfatin-1

Shimizu, Hiroyuki; Ohsaki, Aya; Oh-I, Sinsuke; Okada, Shuichi; Mori, Masataka

doi:10.1016/j.peptides.2009.01.002

Cited by 78 publications

(67 citation statements)

References 17 publications

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“…Our study, by revealing a key cellular process, substantiated the hypothesis that peripheral nesfatin-1 signals to the brain via interacting with the afferent vagus nerves [5,10]. This interaction could underlie the anorexigenic action of peripherally-produced nesfatin-1 under physiological conditions and serve as the therapeutic sensor of exogenous nesfatin-1 for treating patients with hyperphagic obesity.…”

Section: Discussionsupporting

confidence: 79%

“…Both M30 and nesfatin-1 inhibit food intake when administered peripherally as well as centrally [1,5]. However, in mice pretreated with CAP, a procedure to deplete CAP-sensitive afferent nerves, peripheral administration of M30 fails to show anorexigenic action [10]. These results have suggested that induction of anorexia by nesfatin-1 and its active segment M30 is, at least in part, due to activation of CAP-sensitive afferent…”

Section: Relationship Between Nesfatin-1-responsive Neurons and Cck-8mentioning

confidence: 99%

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Nesfatin-1 evokes Ca2+ signaling in isolated vagal afferent neurons via Ca2+ influx through N-type channels

Iwasaki

Nakabayashi

Kakei

et al. 2009

Biochemical and Biophysical Research Communications

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Section: Discussionsupporting

confidence: 79%

Section: Relationship Between Nesfatin-1-responsive Neurons and Cck-8mentioning

confidence: 99%

Nesfatin-1 evokes Ca2+ signaling in isolated vagal afferent neurons via Ca2+ influx through N-type channels

Iwasaki

Nakabayashi

Kakei

et al. 2009

Biochemical and Biophysical Research Communications

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“…N1 is an adipocytokine that plays a role in regulating appetite, having been reported in correlation with the low BMI levels [26,27]. It has been shown to stimulate glycose-dependent insulin secretion [28].…”

Section: Discussionmentioning

confidence: 99%

Nesfatin-1 and Vitamin D levels may be associated with systolic and diastolic blood pressure values and hearth rate in polycystic ovary syndrome

Şahin

Ural

et al. 2015

Biomol Biomed

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Polycystic ovary syndrome (PCOS) is one of the most common causes of female infertility. It affects nearly 5-10% of young women. It is characterized by the presence of hirsutism, acne, anovulation, hyperandrogenism, polycystic ovaries, and infertility [1]. Many mechanisms have been reported to be responsible for the pathophysiology of PCOS. The condition is thought to be determined by complex interactions between the hypothalamic-pituitary-ovarian or hypothalamic-pituitary-adrenal axis functions and metabolic disorders, such as obesity, insulin resistance (IR), and compensatory hyperinsulinemia [2]. PCOS increases the prevalence of hyperglycemia, hypertension, and dyslipidemia [3], increasing thus the risk of developing cardiovascular diseases [4].Nesfatin-1 (N1) is derived from nucleobindin 2 (NUCB2), which is encoded by the NUCB2 gene. It is a newly identified peptide that has 82 amino acids [5]. It is released from several tissues including forebrain, hindbrain, brainstem, spinal cord, adipose tissues [6]. It has an anorexigenic effect and plays an important role in hypothalamic pathways such as regulating food intake, energy homeostasis, water intake, and body temperature [7,8]. In addition, it exerts cardiovascular and hypertensive effects [9]. It is closely related to glucose, insulin metabolism, and IR [5,10]. Several studies have demonstrated N1 to be associated with body mass index (BMI), IR, inflammatory stimulation in diabetes, hypertension, and PCOS [9][10][11]. It may also affect the control of the reproduction system, e.g. puberty onset and gonadotropin secretion [12]. ABSTRACTObesity, insulin resistance (IR), inflammation, and hyperandrogenism may lead to polycystic ovary syndrome (PCOS) and hypertension. Nesfatin-1 (N1) may be related to IR, obesity, and hypertension. Furthermore, a vitamin D (VD) deficiency is associated with hypertension and PCOS. We aimed to investigate N1 and VD levels in PCOS that have an effect on systolic and diastolic blood pressure (BP) and heart rate (HR). This study included 54 patients with PCOS and 48 age-body mass index (BMI)-matched healthy controls. PCOS was diagnosed according to clinical practice guidelines. Ferriman-Gallwey scores (FGS) were calculated, while N1, VD, and other hormonal and biochemical parameters were measured for all subjects. Systolic and diastolic BP was measured as well. HR was calculated using an electrocardiogram. The levels of N1 (p < 0.001), high-sensitivity C-reactive protein (hs-CRP) (p = 0.036), homeostasis model assessment as an index of insulin resistance (HOMA-IR) (p < 0.001), systolic (p < 0.001) and diastolic (p < 0.001) BP and HR (p < 0.001) in the PCOS group were significantly higher than in the control group. However, the VD levels of the PCOS group were lower than the control group (p = 0.004). N1 had a strong positive correlation with BMI, HOMA-IR, hs-CRP, luteinizing hormone, systolic and diastolic BP, and HR. VD levels were negatively correlated with HOMA-IR and luteinizing hormone. Elevated N1 and decreased VD levels may...

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“…Nesfatin/NUCB2 is composed of a signal N-terminal peptide of 24 amino acids, and a protein structure containing 396 amino acids [13]. It has been reported that nucleobindin-2 (NUCB2) is classified into the Nterminal nesfatin-1, nesfatin-2 and the C-terminal nesfatin-3 by prohormone -convertase1/3 [14,15].…”

Section: Aerobic Exercise and Herb Supplementation Increase Liver Andmentioning

confidence: 99%

Effects of endurance training and herb supplementation on tissue nesfatin-1/nucleobindin-2 and ghrelin mRNA expression

Shirvani¹,

Ghanbari–Niaki²,

Rahmati-Ahmadabad

et al. 2017

Int J Appl Exerc Physiol

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ABSTRACT:The aim of present study was to investigate the effects of aerobic training with and without Pistacia-atlantica (Bane) extraction as a plant rich in fatty acids, on rat tissues nesfatin-1/nucleobindin-2 and ghrelin gene expression and also on plasma lipid and lipoproteins profiles.Twenty healthy and intact Wistar rats were obtain and randomly were assigned into saline-control (SC), saline-training (ST), Bane-control (BC), and Bane-training (BT) groups. Training groups ran on a motor driven treadmill (at intensity 25m/min, 5days/wk.) for 8 weeks. Rats were orally received saline or bene solution (100 mg/kg and 7.5ul/g of body weight). Blood was collected to determine biochemical variables and liver and visceral fat were also obtain for Nesfatin-1/nucleobindin-2 and ghrelin mRNA expressions by using a Real-time PCR technique.A higher and significant nesfatin-1 mRNA expressions in liver and visceral fat and liver estradiol were observed in trained groups. However, the level of ghrelin expression was lower in trained groups when compared to control rats. In general, lower tissues nesfatin-1mRNA expression and lower plasma and higher estradiol HDL-C were observed in bane-treated rats. A negative and positive correlation between liver estradiol and liver ghrelin expression, plasma estradiol, HDL-C and visceral fat nesfatin-1 expression were found respectively. The results of present study indicate that exercise combined with bane-treatment induced considerable changes on liver and visceral fat nesfatin-1 and ghrelin expression which was accompanied with a significant change in plasma HDL-C as a cardiovascular risk factor.

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A new anorexigenic protein, nesfatin-1

Cited by 78 publications

References 17 publications

Nesfatin-1 evokes Ca2+ signaling in isolated vagal afferent neurons via Ca2+ influx through N-type channels

Nesfatin-1 evokes Ca2+ signaling in isolated vagal afferent neurons via Ca2+ influx through N-type channels

Nesfatin-1 and Vitamin D levels may be associated with systolic and diastolic blood pressure values and hearth rate in polycystic ovary syndrome

Effects of endurance training and herb supplementation on tissue nesfatin-1/nucleobindin-2 and ghrelin mRNA expression

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