Water, the most widely‐used solvent in Nature, has received considerable interest as an environmentally benign solvent in organic syntheses. The present account focuses on the use of water as the reaction medium under a variety of reaction conditions, including ambient temperature and pressure, heating/reflux, microwave irradiation and ultrasonication in the presence or absence of homogeneous/heterogeneous catalysts, in implementing the syntheses of a diverse range of heterocyclic scaffolds of biological significance reported during the period 2013–2017.