A new aliphatic alcohol and cytotoxic chemical constituents from <i>Acorus gramineus</i> rhizomes

Kim, Ki‐Hyun; Kang, Hee Rae; Eom, Hee Jeong; Kim, Chung Sub; Choi, Sang Un; Lee, Kang Ro

doi:10.1080/09168451.2015.1031079

Cited by 5 publications

(5 citation statements)

References 21 publications

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“…The volatile components of Acorus species are regarded as their main source of pharmacological activities, which includes sedative, digestive, analgesic, diuretic, and antifungal properties. Therefore, the compositional analyses of essential oils for specific Acorus species have been conducted by different groups (Jaiswal et al ., ; Kim et al ., ; Zhang et al ., ; Vijayakumar et al ., ). Three different Acorus species, including rhizomes of A .…”

Section: Resultsmentioning

confidence: 99%

“…And ATR is the best one in potentiating neuronal differentiation in PC12 cells. Asarones are the main active ingredients of ATR, AGR, or ACR; all these three species contain α‐asarone and β‐asarone (Jaiswal et al ., ; Kim et al ., ; Jo et al ., ). In GC–MS profiling of Acorus volatile oils, β‐asarone forms a major portion of the essential oil constituents.…”

Section: Discussionmentioning

confidence: 98%

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Comparative Study of DifferentAcorusSpecies in Potentiating Neuronal Differentiation in Cultured PC12 Cells

Lam

Huang

Yao

et al. 2017

Phytotherapy Research

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Acori Tatarinowii Rhizoma (ATR), the rhizome of Acorus tatarinowii Schott, is a common traditional Chinese medicine being used clinically for mental disorder. However, other Acorus species herbs are all having the same Chinese name 'Chang Pu', making the confusion in herbal market. Acori Graminei Rhizoma (AGR) and Acori Calami Rhizoma (ACR) are common adulterants of ATR. Here, we aim to provide a comparative analysis between ATR, AGR, and ACR in potentiating neuronal differentiation. Volatile oil, derived from Acorus species, was applied onto cultured PC12 cells, and various parameters were determined: (i) transcriptional activation of neurofilament promoters was determined by the promoter-driven luciferase activity assay; (ii) the neurite outgrowth of PC12 cells was captured and measured; and (iii) the neurofilament expression and its underlying mechanism were analyzed by western blotting. The co-treatment of ATR, AGR, or ACR volatile oil with low concentration of nerve growth factor (NGF) could potentiate the NGF-induced neuronal differentiation in cultured PC12 cells. In addition, application of protein kinase A inhibitor H89 in cultures blocked the induction of neurofilament. Among these three Acorus species, ATR volatile oil showed the highest NGF-induced induction in neurite outgrowth and neurofilament expression, as compared with that of AGR and ACR. Copyright © 2017 John Wiley & Sons, Ltd.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 98%

Comparative Study of DifferentAcorusSpecies in Potentiating Neuronal Differentiation in Cultured PC12 Cells

Lam

Huang

Yao

et al. 2017

Phytotherapy Research

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“…DCX can stabilize microtubules and play a key role in the localization of newborn neurons, and it is briefly expressed in the early stages of the development of neurons (Kim et al, ; Guerra de Souza et al, ). Nestin has an important role in the differentiation of neurons and promoting the establishment of neural connections among neurons (Liu et al, ; Deng et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Acorus gramineus , a perennial herb Araceae, has been used as a traditional herbal medicine in Asia clinical treatment against central nervous system diseases, such as dementia, stroke, and so on (Kim et al, ; Khwairakpam et al, ). Previous studies have demonstrated that volatile oil from A. gramineus may protect nervous and enhance the function of learning and memory (Liu et al, ), and volatile oil from A. gramineus could regulate the expression of apoptotic genes and inhibit the apoptosis of nervous (Chen et al, ; Deng et al, ).…”

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confidence: 99%

Volatile Oil from Acorus gramineus Ameliorates the Injury Neurons in the Hippocampus of Amyloid Beta 1‐42 Injected Mice

Gao

Hong-qing²,

et al. 2019

The Anatomical Record

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In recent years, the extraction fraction of volatile oil from Acorus gramineus has significant effects on anti‐dementia and improving the learning and memory of animals. To date, limited studies have determined whether volatile oil from A. gramineus has the protective effect on neuronal damage. The aim of this study was to investigate the protective effects of volatile oil from A. gramineus on Alzheimer's disease (AD) mice, by means of behavior test, immunohistochemistry and western blot methods. In this study, mice were injected with Aβ1‐42 in the bilateral hippocampus to establish the AD model. On the seventh day after modeling, the mice with cognitive dysfunction were selected by the novel object recognition task. Subsequently, the volatile oil treatment groups underwent intragastric administration for per 10 g body weight 2.5 or 5 μL volatile oil from A. gramineus for 3 weeks. The control group and the AD group were given the same amount of saline. Our results showed that after treatment of volatile oil from A. gramineus, the number of Doublecortin and Nestin positive cells increased significantly, suggesting that the volatile oil from A. gramineus may induce the regeneration of hippocampal neurons in mice, and promote the growth of hippocampal neurons by upregulation of brain‐derived neurotrophic factor, tyrosine protein kinase B, and neurotrophin‐3 expression. These results might provide more experimental evidences for underlying mechanism about the neuroprotective effects of volatile oil from A. gramineus against AD relevant symptoms. Anat Rec, 302:2261–2270, 2019. © 2019 American Association for Anatomy

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“…Considering these problems it is necessary to find a safe, effective and natural way for pest control. Plants provide an alternative to currently used pesticides for pest control, as they are a rich source of bioactive chemicals (Kim et al 2005). Botanical products are compatible with ecosystems, have lower toxicity to mammals and non-target organisms and lower persistence in the environment than synthetic insecticides (Liu et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Journal of Plant Protection Research

Shafiei¹,

Ahmadi²,

Asadi³

2018

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Aphids are one of the most important economic pests and vectors of viral diseases in crops. Brevicoryne brassicae L., one of the most serious aphid pests in Brassicaceae, if not controlled, often reaches very high densities. The present study compared the systemic effects of ethanolic, methanolic and aqueous Melia azedarach L., Peganum harmala L., Calendula officinalis L. and Otostegia persica Boissier extracts with two systemic pesticides, acetamiprid and pirimicarb (at the maximum label-recommended rate). Population growth percentages of B. brassicae through leaf spraying under greenhouse conditions were assessed. The chemicals were sprayed on one of the leaves in greenhouse condition. The results indicated that all the plant extracts have systemic effects at different levels. Among different extracts, O. persica ethanolic extract, P. harmala methanolic extract and M. azedarach aqueous extract resulted in a reduction of the B. brassicae population.

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A new aliphatic alcohol and cytotoxic chemical constituents from Acorus gramineus rhizomes

Cited by 5 publications

References 21 publications

Comparative Study of DifferentAcorusSpecies in Potentiating Neuronal Differentiation in Cultured PC12 Cells

Comparative Study of DifferentAcorusSpecies in Potentiating Neuronal Differentiation in Cultured PC12 Cells

Volatile Oil from Acorus gramineus Ameliorates the Injury Neurons in the Hippocampus of Amyloid Beta 1‐42 Injected Mice

Journal of Plant Protection Research

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