A neutrophil cell membrane-biomimetic nanoplatform based on l-arginine nanoparticles for early osteoarthritis diagnosis and nitric oxide therapy

Abstract

Osteoarthritis (OA) is a common debilitating disease of articular joints, for which no disease-modifying medical early diagnosis and therapy is currently available. Inefficient delivery of drug into inflamed chondrocytes has...

The Importance of Neutrophils in Osteoarthritis: Current Concepts and Therapeutic Perspectives

“…This platform suppresses the expression of inflammatory factors or is loaded with a Ru complex to facilitate the release of a large amount of ROS by cells. In addition, this therapeutic scheme was found to be effective in preventing apoptosis in inflamed chondrocytes through autophagy modulation [178].…”

“…Moreover, neutrophil-NPs mimic the natural adhesion between neutrophils and chondrocytes, which increases their cartilage penetration for targeting chondrocytes [176,177]. Anti-inflammatory activity and apoptosis inhibition of inflamed chondrocytes have been demonstrated for NPs in OA [178]. Evaluating the effect of neutrophil-NPs on the arthritis model showed their effectiveness in ameliorating joint damage and suppressing overall arthritis severity [171].…”

Cell membrane coated nanoparticles: cutting-edge drug delivery systems for osteoporosis therapy

“…Additionally, the macrophage membrane actively counteracts proinflammatory cytokines, thereby exerting a localized inhibitory influence on inflammation. 79 A comparative analysis of this approach with the utilization of macrophages as carriers for ROS-responsive nanoparticles highlights the suitability of the strategy involving cell membrane-coated drug delivery systems for the management of inflammatory diseases (Fig. 5).…”

“…For instance, neutrophil-cell-membrane-based biomimetic nanoparticles (NM-LANPs@Ru) could be directly targeting inflamed joints, acting as a nitric oxide (NO) delivery system and exhibiting excellent fluorescence/photoacoustic imaging properties. 79…”

Convergence of nanomedicine and neutrophils for drug delivery

“…Even though the extrusion method is time-consuming, and the integrity of membrane coating and size distribution of particles are not optimal by ultrasonic method, the simplicity of these membrane coating methods enables versatile applications for a wide range of nanoparticle cores with different properties. Lipids (liposomes) [ 30 ], peptides, proteins, polymers [ 31 , 32 ], and inorganic materials like silicon dioxide [ 33 ] and gold are commonly used as nanoparticle cores in different contexts. Irrespective of the method employed for neutrophil membrane coating, a common challenge lies in achieving uniform coating integrity, often resulting in partial coverage of most nanoparticles [ 34 ].…”