A Neuroendocrine-Based Regulatory Fatigue Model

Abstract

The proposed model will facilitate testing of interventions based on the premise that common neuroendocrine transmitters provide the mechanisms of fatigue in patients diagnosed with chronic illnesses, such as with cancer treatment-related fatigue. The model may also be used to identify predictors of fatigue in specific patient populations, provide guidance for clinicians in their selection of precise interventions to be implemented, and identify the effects of treatments captured in these populations. By clearly identifying the mechanisms of fatigue, we can discover which interventions are effective for particular types of fatigue.

Cancer-related fatigue: An update

“…An elevation in proinflammatory cytokines (in turn stimulated by interferon-α and IL-2) affects the HPA function, leading to a reduction in cortisol output. Another intriguing model relates to the importance of disruption of the circadian rhythms in CRF [22]. Most biologic functions of humans have a circadian rhythm.…”

“…Dysfunctions of the hypothalamic-pituitary-adrenal axis (HPA) are described in patients with CRF and in chronic fatigue syndrome. These include decreased steroid output, lower levels of gonadotropins and androgens, and reduced HPA function on neuroendocrine challenge tests [22]. An elevation in proinflammatory cytokines (in turn stimulated by interferon-α and IL-2) affects the HPA function, leading to a reduction in cortisol output.…”

The Efficacy of Acupressure at theSanyinjiaoPoint in the Improvement of Women's General Health

“…31 It has also been shown that cognition and controlling of mood in the central nervous system can be modulated by acupressure. 32 In addition, the results of another study have revealed that using acupressure bands can diminish the severity of chemotherapy-induced nausea and vomiting in women with cancer. 33 Several kinds of acupressure are currently practiced as an alternative therapy, although all of them stimulate the same sensitive spots.…”

Effect of Fatigue on Quality of Life in Pediatric Oncology Patients

“…İkinci olarak uygulanacak girişimler ise yorgunluğun meydana gelmesini önlemelidir. Ayrıca, Winnigham (20) fiziksel aktivitenin çok önemli olduğunu kabul etmektedir (21).…”

“…Böylelikle kavramlar arasında ilişki kurularak parçalardan uyumlu bir bütün elde edilmekte ve oluşturulan bakımın kalitesi arttırılmaktadır. Yorgunluk modelleri yorgunluğun nedenlerini belirlemede ve girişimleri planlamada sağlık profesyonellerine ışık tutmaktadır (21).…”