A Neuro-Ectodermal Tumor in the Bladder

Hurwitz, Roger A.; Fitzpatrick, Terence J.; Ackerman, Irving; Cove, Karen; Benjamin, John A.; Kalinowski, Richard; Cooper, Jay M.

doi:10.1016/s0022-5347(17)55478-6

Cited by 16 publications

(8 citation statements)

References 8 publications

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“…3,[5][6][7][8] Like bladder paragangliomas, bladder CPGs can be biochemically functional and can release catecholamines, especially during tumour manipulation as occurred in our patient. 5,6,8 A high index of clinical suspicion is necessary to preoperatively identify bladder paragangliomas and rarer CPGs. However, many of these tumours often present only with gross hematuria in the absence of hypertension or micturition attacks, making their preoperative identification difficult.…”

Section: Discussionmentioning

confidence: 69%

“…Surprisingly, postoperative serum and urine catecholamine levels were within normal limits. To our knowledge, this is only the sixth reported case of CPG of the urinary bladder 3,[5][6][7][8] and the first case to result in hemodynamic instability during tumour resection.…”

Section: Introductionmentioning

confidence: 77%

“…To date, no bladder CPG has demonstrated malignant behaviour; however, follow-up is limited (Table 1) and all cases have been described as isolated reports. 3,[5][6][7][8] Due to the limited experience with these rare bladder tumours, it is best to regard bladder CPGs as potentially malignant neoplasms like their paraganglioma counterparts that require complete surgical excision and adequate clinical follow-up.…”

Section: Resultsmentioning

confidence: 99%

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Composite paraganglioma-ganglioneuroma of the urinary bladder: a rare neoplasm causing hemodynamic crisis at tumour resection

Chen

Boag

Beiko

et al. 2013

CUAJ

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A 64-year-old man presented with gross painless hematuria. Cystoscopy revealed a submucosal bladder neck mass covered by normal urothelium. During transurethral resection, the patient developed hemodynamic crisis including sinus bradycardia. Histopathologic examination revealed a primary bladder composite paraganglioma-ganglioneuroma (CPG). The patient underwent partial cystectomy and is symptom-free after one year. Bladder CPGs are extremely rare neoplasms that may result in lifethreatening catecholamine secretion, especially during tumour manipulation. These tumours require complete surgical excision and should be included in the differential diagnosis of any solitary bladder mass covered by normal urothelium, especially when there is a history of hypertension or micturition attacks.Can Urol Assoc J 2009;3(5):E45-E48

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Section: Discussionmentioning

confidence: 69%

Section: Introductionmentioning

confidence: 77%

Section: Resultsmentioning

confidence: 99%

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Composite paraganglioma-ganglioneuroma of the urinary bladder: a rare neoplasm causing hemodynamic crisis at tumour resection

Chen

Boag

Beiko

et al. 2013

CUAJ

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“…Microscopic fields of ganglioneuroma are known to occur in pheochromocytomas of the bladder. 3 Two cases out of 40 extra-adrenal pheochromocytomas in children originated in the bladder wall, 4 which presented a distinct symptom complex of headache, fainting, and hypertension initiated by voiding. Although several cases of malignant paraganglioma (pheochromocytoma) of the urinary bladder have been reported, 5 only one case of neuroblastoma of the bladder has ever been reported in the world literature.…”

Section: Discussionmentioning

confidence: 99%

Neuroblastoma of the Urinary Bladder, Preclinically Detected by Mass Screening

Yokoyama¹,

Hirakawa²,

Ueno³

et al. 1999

Pediatrics

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ABSTRACT. Background. Since the introduction of mass screening of infants for neuroblastoma, the incidence of neuroblastoma has increased in Japan. The reason for this increased incidence is the possible inclusion of many neuroblastomas that would have regressed spontaneously and would never have been detected clinically. An extremely rare tumor at the dome of the urinary bladder in a 7-month-old infant was detected by the mass screening.Methods. A case of neuroblastoma of the urinary bladder is reported with a review of the literature. The data in the Japan Children's Cancer Registry are also reviewed to analyze the incidence and the site of origin of neuroblastoma for evaluation of mass screening.Results. A 7-month-old female infant was referred because of a positive urine vanillylmanderic acid screening test. Ultrasonography showed a solid mass attached to the urinary bladder. At laparotomy a 35 ؋ 30 ؋ 25-mm egg-shaped tumor was found at the dome of the bladder, and a partial cystectomy was performed. During the operation no changes in blood pressure occurred when the tumor was manipulated. Histologic diagnosis was rosette-fibrillary neuroblastoma originating in the bladder wall, with a favorable Shimada histopathologic classification. N-myc was not amplified, which predicted a favorable prognosis, and no postoperative chemotherapy was given. The patient was free of symptoms and tumor after a follow-up period of 16 months. Literature review revealed that this was the second case of neuroblastoma of the urinary bladder ever reported in the world, although several cases of pheochromocytoma originating in the bladder wall had been reported. Both neuroblastoma and pheochromocytoma derive from the neural crest. The sympathogonia from the neural crest, a common stem cell, differentiates into a ganglion cell or into a secretory cell known as a chromaffin cell, able to manufacture catecholamines. The first case in the world that was reported as neuroblastoma of the urinary bladder was in a 4-month-old infant who was noted to have a 4-cm lower abdominal mass on routine physical examination. A ganglioneuroblastoma of the dome of the bladder was excised and the patient was doing well. On reviewing the Japan Children's Cancer Registry, the incidence of neuroblastomas in infants has increased as well as the number of stage 1, 2, and 4s (stage 4 special) neuroblastomas since the introduction of mass screening. However, there has been no significant change in the number of stage 3 or 4 diseases diagnosed in older children. According to the Japan Children's Cancer Registry, pelvic origin neuroblastoma, which has been noted to have spontaneous regression, was more frequent in the primary tumors detected by mass screening when compared with those presenting clinically. During preparation of this manuscript another case of bladder dome neuroblastoma was detected by urinary vanillylmanderic acid screening of 6-month-old infants for neuroblastoma in Japan.Conclusion. These extremely rare cases of neuroblastoma of the urinary blad...

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“…5). Mis cellaneous forms combining chromaffin and neural ele ments are described [14], This inhomogeneous structure of the tissues as well as the size of the tumor itself might be responsible for the different hormonal activity.…”

Section: Discussionmentioning

confidence: 99%

Pheochromocytoma of the Urinary Bladder - a Case Report and Review of the Literature

Schütz

Vogel²

1984

Urol Int

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A pheochromocytoma of the urinary bladder in an 18-year-old male patient with typical clinical symptoms is reported. The blood pressure after micturition was above 300 mm Hg, the vanillylmandelic acid concentration in the 24-hour urinary excretion was elevated 4 or 5 times. Computed tomography and sonography were especially suited for diagnostic localization. The postoperative course has to be supervised, especially as recurrence has been observed.

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A Neuro-Ectodermal Tumor in the Bladder

Cited by 16 publications

References 8 publications

Composite paraganglioma-ganglioneuroma of the urinary bladder: a rare neoplasm causing hemodynamic crisis at tumour resection

Composite paraganglioma-ganglioneuroma of the urinary bladder: a rare neoplasm causing hemodynamic crisis at tumour resection

Neuroblastoma of the Urinary Bladder, Preclinically Detected by Mass Screening

Pheochromocytoma of the Urinary Bladder - a Case Report and Review of the Literature

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