A neural network underlying individual differences in emotion and aggression in male golden hamsters

David, Jesuye; Cervantes, M. Catalina; Trosky, K. A.; Salinas, Juan A.; Delville, Yvon

doi:10.1016/j.neuroscience.2004.04.031

Cited by 73 publications

(57 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Discussionmentioning

confidence: 98%

“…During puberty, AAS exposure increased spine densities on neurons in the medial amygdala and the hippocampus and also increased aggression displayed by intact male rats (Farrell and McGinnis, 2004). This aggressive behavior has been linked to the medial amygdala (Masco and Carrer, 1990, Wood and Coolen, 1997, Grimes et al, 2003, David et al, 2004, Giammanco et al, 2005.In further support of this premise, long-term behavioral effects have been found in male rats pubertally exposed to AAS. For instance, aggression remained elevated several weeks after withdrawal from pubertal AAS exposure in adult male rats, which may be a result of learned behavior (Farrell and McGinnis, 2004).…”

mentioning

confidence: 92%

See 1 more Smart Citation

Pubertal exposure to anabolic androgenic steroids increases spine densities on neurons in the limbic system of male rats

Cunningham¹,

Claiborne²,

McGinnis³

2007

Neuroscience

View full text Add to dashboard Cite

Human studies show that the number of teenagers abusing anabolic androgenic steroids (AAS) is increasing. During adolescence, brain development is altered by androgen exposure, which suggests that AAS may potentially alter central nervous system development. The goal of the present study was to determine whether pubertal AAS exposure increased dendritic spine densities on neurons within the medial amygdala and the dorsal hippocampus. Pubertal gonadally intact male rats received the AAS testosterone propionate (5mg/kg) or vehicle for 5 days/week for four weeks. To determine the long-term implications of pubertal AAS use, another set of males received the same AAS treatment and were then withdrawn from AAS exposure for 4 weeks. Results showed that pubertal AAS exposure significantly increased spine densities on neurons in the anterior medial amygdala, posterodorsal medial amygdala, and the CA1 region of the hippocampus compared to gonadally intact control males. Spine densities returned to control levels within the anterior medial amygdala and the posterodorsal medial amygdala 4 weeks after withdrawal. However, spine densities remained significantly elevated after AAS withdrawal in the CA1 region of the hippocampus, suggesting that pubertal AAS exposure may have a long-lasting impact on CA1 hippocampal neuroanatomy. Since pubertal AAS exposure increased spine densities and most excitatory synapses in the central nervous system occur on dendritic spines, AAS may increase neuronal excitation. It is proposed that this increase in excitation may underlie the behavioral responses seen in pubertal AAS-treated male rats. KeywordsTestosterone; Medial Amygdala; Hippocampus; Withdrawal; DiI Anabolic androgenic steroid (AAS) use by human adolescent males is on the rise (Burnett and Kleiman, 1994, DuRant et al., 1995, Melia et al., 1996. This is of particular concern because puberty is a time when increasing endogenous hormone levels influence brain maturation (Primus and Kellogg, 1990, Sisk et al., 2003), which may be adversely affected by AAS exposure. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access Author ManuscriptNeuroscience. Author manuscript; available in PMC 2010 November 15. Two brain regions that have been found to be sensitive to pubertal hormones in both human and animal studies are the hippocampus and amygdala (Meyer et al., 1978, Giedd et al., 1996a, Giedd et al., 1996b, Romeo and Sisk, 2001, Giedd et al., 2006, Zehr et al., 2006. The volume of the amygdala and hippocampus has been shown to increase with age in human adolescents (Giedd et al., 1...

show abstract

Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 92%

Pubertal exposure to anabolic androgenic steroids increases spine densities on neurons in the limbic system of male rats

Cunningham¹,

Claiborne²,

McGinnis³

2007

Neuroscience

View full text Add to dashboard Cite

show abstract

“…David et al (86) reported that the expression of P-CREB was increased in the central and medial nuclei of the amygdala following the training of bar-pressing for a delayed food reinforcement (the reward was delivered 1 min after a lever press). In parallel to our studies on c-Fos (229), we have also investigated expression of Zif268 following bar-pressing response reinforced with food.…”

Section: G Pattern Of Expression Of Other Activity Markers In the Ammentioning

confidence: 99%

Functional Internal Complexity of Amygdala: Focus on Gene Activity Mapping After Behavioral Training and Drugs of Abuse

Knapska¹,

Radwańska²,

Werka³

et al. 2007

Physiological Reviews

137

134

View full text Add to dashboard Cite

The amygdala is a heterogeneous brain structure implicated in processing of emotions and storing the emotional aspects of memories. Gene activity markers such as c-Fos have been shown to reflect both neuronal activation and neuronal plasticity. Herein, we analyze the expression patterns of gene activity markers in the amygdala in response to either behavioral training or treatment with drugs of abuse and then we confront the results with data on other approaches to internal complexity of the amygdala. c-Fos has been the most often studied in the amygdala, showing specific expression patterns in response to various treatments, most probably reflecting functional specializations among amygdala subdivisions. In the basolateral amygdala, c-Fos expression appears to be consistent with the proposed role of this nucleus in a plasticity of the current stimulus-value associations. Within the medial part of the central amygdala, c-Fos correlates with acquisition of alimentary/gustatory behaviors. On the other hand, in the lateral subdivision of the central amygdala, c-Fos expression relates to attention and vigilance. In the medial amygdala, c-Fos appears to be evoked by emotional novelty of the experimental situation. The data on the other major subdivisions of the amygdala are scarce. In conclusion, the studies on the gene activity markers, confronted with other approaches involving neuroanatomy, physiology, and the lesion method, have revealed novel aspects of the amygdala, especially pointing to functional heterogeneity of this brain region that does not fit very well into contemporarily active debate on serial versus parallel information processing within the amygdala.

show abstract

“…Individuals with proactive coping style, besides displaying high levels of aggression, generally exhibit short attack latency and impulsive decision--making and score high in frustration tests. Furthermore, they take risks in the face of potential danger, are usually novelty--seekers (Koolhaas et al, 1999;David et al, 2004;Steimer and Driscoll, 2005), and score high for active avoidance (Koolhaas et al, 1999). In the fox experiment, as well as in other studies, it has been shown that the HPA axis response can be down regulated and that this can be linked to selection for less fearful behaviour, such as more exploration of novel environments and a tendency to approach humans (Trut, 1999).…”

Section: Coping Style and Stress Reactivitymentioning

confidence: 96%

Early Experience, Maternal Care and Behavioural Test Design : Effects on the Temperament of Military Working Dogs

Foyer

2015

Linköping Studies in Science and Technology. Dissertations

View full text Add to dashboard Cite

Domestication has resulted in animals with broad variations between as well as within breeds, which allows for the selection and breeding of animals for preferred traits. This selection has affected both the genotypes and phenotypes of animals. In dogs, it has allowed for breeding for different purposes, such as companionship or the performance of specific tasks, e.g., herding, hunting, searching and protecting. Each of these types of working dogs has specific traits that are, in part, controlled by genes; however, genes are not solely responsible for the variations in the traits of an individual. The environment also plays a role, which has been studied in rodents and primates in recent decades. For instance, it has been shown that the amount of maternal care that a rat receives as a pup affects its temperament later in life; the more maternal care, i.e., licking, grooming and arched--back nursing (LG--ABN) that a rat receives, the more stress resistant, less reactive and more explorative it will be as an adult. However, the question is whether this is also true for dogs, and the investigation of how temperament in dogs is affected by environmental factors early in life is the main objective of this thesis. Three of the studies presented in this thesis focused on investigating the general parameters, particularly maternal care, that influences offspring behaviour to contribute to the understanding of temperament development in military working dogs. One of these studies concentrated on the environmental factors that influence dogs early in life, and the results indicated that some factors, such as parity, litter size and birth season, affect temperament later in life. Another study investigated how females take care of their young, and the results demonstrated that females vary in their maternal style during the first three weeks postpartum and that this variation affects the temperament of the offspring. The third study focused on factors in the home environment, and the results showed that dogs approved through the evaluative temperament test were significantly associated with being hyperactive or restless and having difficulty settling down in the home environment. However, those dogs were also left home alone for more hours in a day than non--approved dogs. To be able to operate functionally, a military working dog needs to possess certain traits, or a certain temperament, and a vital characteristic is the way it responds to and copes with stress. This was investigated during an evaluative temperament test used to select dogs suitable for further training. Surprisingly, the results in the fourth study showed that the dogs approved for further training had significantly higher levels of salivary cortisol both before and after the test compared with the non--approved dogs. These findings may be of profound importance for understanding individual variations in behaviour and improving breeding schemes for working dogs. POPULÄRVETENSKAPLIG SAMMANFATTNINGFör över 15 000 år sedan började våra anfäder avla ...

show abstract

A neural network underlying individual differences in emotion and aggression in male golden hamsters

Cited by 73 publications

References 57 publications

Pubertal exposure to anabolic androgenic steroids increases spine densities on neurons in the limbic system of male rats

Pubertal exposure to anabolic androgenic steroids increases spine densities on neurons in the limbic system of male rats

Functional Internal Complexity of Amygdala: Focus on Gene Activity Mapping After Behavioral Training and Drugs of Abuse

Early Experience, Maternal Care and Behavioural Test Design : Effects on the Temperament of Military Working Dogs

Contact Info

Product

Resources

About