A network pharmacology study of reduning injection for the treatment of coronavirus disease-19

Wu, Jian; Ruan, Dong-Dong; Fu, Tong-Fei; Yuan, Jun

doi:10.4103/wjtcm.wjtcm_19_20

Cited by 6 publications

(11 citation statements)

References 15 publications

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“…Overall, 48 studies 15 , 19 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 involving 4 CHIs contributed to analysis of the clinical effective rate and YHN+WM was frequently used. There was no significant heterogeneity in the pooled analysis of all included studies ( P > 0.1; I 2 < 50%).…”

Section: Resultsmentioning

confidence: 99%

“…27 studies 15 , 37 , 39 , 42 , 43 , 44 , 51 , 54 , 55 , 59 , 60 , 62 , 65 , 68 , 73 , 74 , 77 , 79 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 with 5 treatments reported the time for disappearance of diarrhea. When P was ≥0.1 and I 2 was ≤50%, the fixed-effects model was used for the meta-analysis and vice versa.…”

Section: Resultsmentioning

confidence: 99%

“…Time for defervescence was estimated in 29 studies 15 , 37 , 39 , 42 , 43 , 44 , 51 , 52 , 54 , 55 , 56 , 59 , 60 , 62 , 68 , 71 , 74 , 76 , 77 , 78 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 91 , 92 with 5 treatments. The random-effects model was used because of the heterogeneity.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Comparative effectiveness of Chinese herbal injections treating for rotavirus enteritis in children: A systematic review and Bayesian network meta-analysis

Niu¹,

Lu²,

Cai³

et al. 2023

Integrative Medicine Research

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Comparative effectiveness of Chinese herbal injections treating for rotavirus enteritis in children: A systematic review and Bayesian network meta-analysis

Niu¹,

Lu²,

Cai³

et al. 2023

Integrative Medicine Research

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“…Many researchers have demonstrated the application of opioid compounds and their receptors in the management of pain in arthritis, without revealing some serious side effects. These receptors are majorly classified on the traditional nomenclature of -δ (delta), -κ (kappa) and -µ (mu), where these receptors are primarily categorized into the family of G protein-coupled receptors (GCPR) 33 . Opioids have been a…”

Section: Discussionmentioning

confidence: 99%

Network Pharmacological Investigation of Sinomenine Action Against Synovitis

Li¹,

Mao²,

Zhou³

et al. 2022

International J. of Pharmacology

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Background and Objective: Synovitis is characterized as the inflammation of the synovial membrane, which often occurs in osteoarthritis.The incidence of this medical condition may be related to age, immunological responses and other co-morbidities. Therefore, the objective of the study was to elucidate the anti-Synovitis potential of sinomenine. Materials and Methods: The associated targets about sinomenine and synovitis were investigated in Homo sapiens, which was then elucidated by the PPI network construction via STITCH database. Furthermore, Cytoscape and its plugin were used for gene ontology (GO) analysis. Results: The literature survey and the network revealed 25 potential target proteins to be associated with sinomenine, of which many proteins such as OPRD1, CHRM1 and DAMGO were found to be significantly related to the bioactive action of sinomenine in Homo sapiens. Moreover, the GO terms which were associated with the functioning of sinomenine for its anti-Synovitis potential were found to be four, analyzed by the functional annotation gene clusters and abundance values of the target proteins. Conclusion: The results of the study demonstrate the anti-Synovitis potential of sinomenine, where its action is dependent upon the molecular mechanisms that exert its beneficial role against synovitis. The core mechanisms that may be related to its anti-synovitis action may be adenylate cyclase-activating G-protein coupled receptor signalling pathway, regulation of smooth muscle contraction, adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signalling pathway and positive regulation of nitric oxide metabolic process.

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“…19 The 6 query proteins interacted as an interactome unit by Cytoscape software v3.7.2 via the protein query of the STRING database. 20 To find more informative data, 100 first neighbors were added to the 6 query proteins and a network was constructed. The network was analyzed by the network analyzer application of Cytoscape and the central nodes based on centrality parameters were determined.…”

Section: Methodsmentioning

confidence: 99%

Central Proteins of Plasma in Response to Low-Level Laser Therapy Involve in Body Hemostasis and Wound Repair

et al. 2020

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Introduction: Low-level laser therapy (LLLT) is accompanied by protein expression change in the body. There are many efforts to find a clear relationship between the differentially expressed proteins. This study aims to find the central differentiated expressed proteins of plasma after LLLT. Methods: Six proteins are extracted from a proteomics study and the network including these query proteins plus 100 first neighbors was constructed. The central proteins were determined based on degree value, betweenness centrality, closeness centrality (CC), and stress (The centrality parameters). Results: Among 106 nodes of the network, 10 proteins were characterized with the most values of degree, betweenness centrality, CC, and stress. These proteins were determined as central proteins in response to LLLT in plasma. Conclusion: Three query proteins, AHSG, FGG, and SERPINA1, plus 7 first neighbors, namely FGA, ALB, KNG1, FN1, APP, TIMP1, and F5, were identified as central proteins which were dysregulated.

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A network pharmacology study of reduning injection for the treatment of coronavirus disease-19

Cited by 6 publications

References 15 publications

Comparative effectiveness of Chinese herbal injections treating for rotavirus enteritis in children: A systematic review and Bayesian network meta-analysis

Comparative effectiveness of Chinese herbal injections treating for rotavirus enteritis in children: A systematic review and Bayesian network meta-analysis

Network Pharmacological Investigation of Sinomenine Action Against Synovitis

Central Proteins of Plasma in Response to Low-Level Laser Therapy Involve in Body Hemostasis and Wound Repair

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