Central Proteins of Plasma in Response to Low-Level Laser Therapy Involve in Body Hemostasis and Wound Repair

Arjmand, Babak; Vafaee, Reza; Razzaghi, Mohammad Reza; Rezaei‐Tavirani, Mostafa; Ahmadzadeh, Arman; Rezaei-Tavirani, Sina; Hamdieh, Mostafa

doi:10.34172/jlms.2020.s9

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…25 Therefore, FLNA down-regulation can be interpreted as an increasing mode in the radio-resistance activity of the treated cells. AHSG, another upregulated hub, is highlighted in the report of Arjmand et al 26 about the deregulation of AHSG and SERPINA1 in response to lowlevel laser radiation. SERPINC1, the third up-regulated hub protein, was down-regulated in the serum of an irradiated rat by low-level laser radiation.…”

Section: Discussionmentioning

confidence: 98%

Hypofractionated Radiation Versus Conventional Fractionated Radiation: A Network Analysis

et al. 2022

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Introduction: Conventional fractionation (CF) and hypofractionation (HF) are two radiotherapy methods against cancer, which are applied in medicine. Understanding the efficacy and molecular mechanism of the two methods implies more investigations. In the present study, proteomic findings about the mentioned methods relative to the controls were analyzed via network analysis.Methods: The significant differentially expressed proteins (DEPs) of prostate cancer (PCa) cell line DU145 in response to CF and HF radiation therapy versus controls were extracted from the literature. The protein-protein interaction (PPI) networks were constructed via the STRING database via Cytoscape software. The networks were analyzed by "NetworkAnalyzer" to determine hub DEPs.Results: 126 and 63 significant DEPs were identified for treated DU145 with CF and HF radiation respectively. The PPI networks were constructed by the queried DEPs plus 100 first neighbors. ALB, CD44, THBS1, EPCAM, F2, KRT19, and MCAM were highlighted as common hubs. VTM, OCLN, HSPB1, FLNA, AHSG, and SERPINC1 appeared as the discriminator hub between the studied cells.Conclusion: 70% of the hubs were common between CF and HF conditions, and they induced radio-resistance activity in the survived cells. Six central proteins which discriminate the function of the two groups of the irradiated cells were introduced. On the basis of these findings, it seems that DU145-CF cells, relative to the DU145-UF cells, are more radio-resistant.

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Section: Discussionmentioning

confidence: 98%

Hypofractionated Radiation Versus Conventional Fractionated Radiation: A Network Analysis

et al. 2022

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“…[2][3][4] There are many documents about the molecular aspect of low-level laser therapy (LLLT), which are concerned with proteomics, genomics, and bioinformatics. [5][6][7] Since the high throughput methods provide large numbers of data, bioinformatics as a useful tool is applied to organize and interpret the findings to present a new concept. 8 Network analysis as one of the bioinformatics fields is an approach that studies the relationship between the assessed data.…”

Section: Introductionmentioning

confidence: 99%

Low-Level Laser Therapy Effects on Rat Blood Hemostasis Via Significant Alteration in Fibrinogen and Plasminogen Expression Level

et al. 2021

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Introduction: There are many documents about the significant role of low-level laser therapy (LLLT) in different processes such as regenerator medicine and bone formation. The aim of this study is to assess the role of LLLT in blood hemostasis in rats via bioinformatic investigation. Methods: The differentially expressed plasma proteins of treated rats via LLLT from the literature and the added 50 first neighbors were investigated via network analysis to find the critical dysregulated proteins and biological processes by using Cytoscape software, the STRING database, and ClueGO. Results: A scale-free network including 55 nodes was constructed from queried and added first neighbor proteins. Fibrinogen gamma, fibrinogen alpha, and plasminogen were highlighted as the central genes of the analyzed network. Fibrinolysis was determined as the main group of biological processes that were affected by LLLT. Conclusion: Findings indicate that LLLT affects blood hemostasis which is an important point in approving the therapeutic application of LLLT and also in preventing its possible complication.

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Efficacy of photobiomodulation in the treatment of avulsed teeth: A systematic review of animal studies

Figueiredo,

Bento,

Sonoda

et al. 2024

Lasers Med Sci

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Central Proteins of Plasma in Response to Low-Level Laser Therapy Involve in Body Hemostasis and Wound Repair

Cited by 3 publications

References 26 publications

Hypofractionated Radiation Versus Conventional Fractionated Radiation: A Network Analysis

Hypofractionated Radiation Versus Conventional Fractionated Radiation: A Network Analysis

Low-Level Laser Therapy Effects on Rat Blood Hemostasis Via Significant Alteration in Fibrinogen and Plasminogen Expression Level

Efficacy of photobiomodulation in the treatment of avulsed teeth: A systematic review of animal studies

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