A Network Map of FGF-1/FGFR Signaling System

Abstract

Fibroblast growth factor-1 (FGF-1) is a well characterized growth factor among the 22 members of the FGF superfamily in humans. It binds to all the four known FGF receptors and regulates a plethora of functions including cell growth, proliferation, migration, differentiation, and survival in different cell types. FGF-1 is involved in the regulation of diverse physiological processes such as development, angiogenesis, wound healing, adipogenesis, and neurogenesis. Deregulation of FGF-1 signaling is not only implicated in tumorigenesis but also is associated with tumor invasion and metastasis. Given the biomedical significance of FGFs and the fact that individual FGFs have different roles in diverse physiological processes, the analysis of signaling pathways induced by the binding of specific FGFs to their cognate receptors demands more focused efforts. Currently, there are no resources in the public domain that facilitate the analysis of signaling pathways induced by individual FGFs in the FGF/FGFR signaling system. Towards this, we have developed a resource of signaling reactions triggered by FGF-1/FGFR system in various cell types/tissues. The pathway data and the reaction map are made available for download in different community standard data exchange formats through NetPath and NetSlim signaling pathway resources.

Fibroblast growth factor 1 levels are elevated in newly diagnosed type 2 diabetes compared to normal glucose tolerance controls

“…nonclassical secretory pathway [13][14][15][16]. Experimental studies suggested that FGF1 exhibited a physiologic profile that included a variety of metabolic responses.…”

Clinicopathological significance of fibroblast growth factor 1 in non–small cell lung cancer

“…Also known as acidic FGF, FGF1 is a 155 amino acid long non-glycosylated polypeptide, which binds to all the 4 known FGFRs [11]. As a potent mitogen, FGF1 functions as a proliferation, differentiation, and survival factor in a wide variety of cell types, especially for vascular endothelial cells.…”

Forced KLF4 expression increases the generation of mature plasma cells and uncovers a network linked with plasma cell stage

“…FGF1 is involved in a plethora of biological processes, including cell growth, proliferation, migration, differentiation, and survival in different cell types. 31 According to the role of KLF4 in supporting plasma cell generation and survival, KLF4 deregulation could be involved in plasma cell tumorigenesis or autoimmune diseases. High levels of KLF4 expression have been reported myeloma patients with t(4;14) translocation, an overexpression of CCND1 or CCND3.…”