A Neoplastic Disease of the Kidney of the Frog, Rana Pipiens

Lucké, Balduin

doi:10.1158/ajc.1934.352

Cited by 126 publications

(36 citation statements)

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“…The cytoplasm of cells with nuclear abnormalities often contains angular elongated bodies that differ from the nuclear inclusions in that they stain lightly with hematoxylin. Cytoplasmic inclusions seem to have been overlooked in Luck6's original accounts of the histopathology of this tumor (17,21), but they have been described by Duryee (9) and are of considerable interest in relation to certain of the electron microscope observations that will be described below.…”

Section: Observationsmentioning

confidence: 99%

“…This malignant tumor occurs in from two to four per cent of frogs of this species, collected in the Lake Champlain region of northern Vermont and adjoining areas of Quebec. In a series of papers Luck6 described its histopathology (17), reported the occurrence of distant metastases (18) and demonstrated the presence in some of the tumors of intranuclear inclusion bodies of a kind commonly seen in virus diseases (17,22). It was subsequently shown by him that tumors could be induced in frogs of the susceptible race by injection of desiccated or glycerinated preparations of tumor.…”

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Electron Microscope Observations on Intracellular Virus-Like Particles Associated With the Cells of the Lucké Renal Adenocarcinoma

Fawcett

1956

The Journal of Cell Biology

166

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Relatively few malignant neoplasms have been described in amphibia. The one that has been studied most extensively is the Luck6 renal adenocarcinoma of the frog, Rana pipiens. This malignant tumor occurs in from two to four per cent of frogs of this species, collected in the Lake Champlain region of northern Vermont and adjoining areas of Quebec. In a series of papers Luck6 described its histopathology (17), reported the occurrence of distant metastases (18) and demonstrated the presence in some of the tumors of intranuclear inclusion bodies of a kind commonly seen in virus diseases (17,22). It was subsequently shown by him that tumors could be induced in frogs of the susceptible race by injection of desiccated or glycerinated preparations of tumor. Similar inoculation of other races or species was without effect. These observations led Luck6 to conclude that the tumors were probably caused by a species-specific, organspecific agent having the characteristics of a virus (19,20). Additional supporting evidence for this conclusion was provided in later work of Schlulnberger and Luck6 (31) in which the tumor was carried for many generations by serial intraocular transplantation. In the course of these experiments it was noted that frogs bearing intraocular tumors very often developed kidney tumors. Similar results have been reported by Rose and Rose (30) in anterior chamber transplants in adult frogs, and by Briggs (4) in tadpoles with tumor implants in the tail fin. In both instances persistently growing adenocarcinomas frequently developed in the kidneys even though the implanted tumor tissue itself regressed. The most reasonable interpretation of these findings seems to be that a tumor agent passed from the implanted tissue to the kidney and there induced a tumor of the same kind. Further evidence of the viral nature of the tumor-inducing material has been provided by the work of Duryee and Doherty (8, 9) who have recently established its filtrability.In the present investigation, thin sections of frog renal tumors have been

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Section: Observationsmentioning

confidence: 99%

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confidence: 99%

Electron Microscope Observations on Intracellular Virus-Like Particles Associated With the Cells of the Lucké Renal Adenocarcinoma

Fawcett

1956

The Journal of Cell Biology

166

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“…Developmental abnormalities can be induced in Xenopus relatively easily while one tumour of the species, a lymphosarcoma, can under certain circumstances, be transmitted to other amphibians. However the most significant discovery in the cancer field resulting from lower vertebrate work was probably that of Lucke (1934), who described a renal adenocarcinoma of the leopard frog (Rana pipiens). A virus was isolated from this tumour and much useful work on transmission and pathogenesis followed.…”

Section: Coopermentioning

confidence: 99%

Diseases of lower vertebrates and biomedical research

Cooper¹

1977

Lab Anim

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“…1 Renal tumors were not observed in non-hybrid animals over the same period. Although Lucké renal tumors are well-known to develop in the leopard frogs, Rana pipiens, in association with virus infection, 3,4 such frequent occurrence of kidney tumors in toads had never been described previously. 5 Our present investigation was undertaken to confirm the observations of Nishioka and Kondo and also to establish a new animal model for studying genetically determined renal carcinogenesis.…”

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Polycystic kidney and renal cell carcinoma in Japanese and Chinese toad hybrids

Masahito

Nishioka

Kondo

et al. 2002

Intl Journal of Cancer

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Frequent development of renal cell carcinomas in hybrids between Japanese toads (Bufo japonicus) and imported Chinese toads (Bufo raddei) was first reported by 2 of our authors in 1987. Such renal tumors of toads had never been observed previously in the laboratory. To confirm the observation and to establish a new animal model system, hybrids between female Japanese and male Chinese toads were newly generated from 3 pairs of parents and pathological changes in their kidneys were examined sequentially over 6 years. In hybrids from 2 of the 3 pairs, bilateral polycystic kidney developed at a high frequency from 3 months after fertilization, this being associated with the emergence of atypical, premalignantappearing cells in proximal tubules. Papillary lesions developed after 12 months and renal cell carcinomas after 48 months. Such pathological changes were never seen in nonhybrid Chinese or Japanese toads. Electron microscopy showed no evidence of any viral participation. This unique toad model may prove useful for investigation of the underlying mechanisms of genetically determined renal cell carcinogenesis.

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A Neoplastic Disease of the Kidney of the Frog, Rana Pipiens

Cited by 126 publications

References 1 publication

Electron Microscope Observations on Intracellular Virus-Like Particles Associated With the Cells of the Lucké Renal Adenocarcinoma

Electron Microscope Observations on Intracellular Virus-Like Particles Associated With the Cells of the Lucké Renal Adenocarcinoma

Diseases of lower vertebrates and biomedical research

Polycystic kidney and renal cell carcinoma in Japanese and Chinese toad hybrids

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