A Necrotizing Enterocolitis-Associated Gut Microbiota Is Present in the Meconium: Results of a Prospective Study

Heida, Fardou H.; Zoonen, Anne G. J. F. van; Hulscher, Jan B F; Kiefte, B.J.C. Te; Wessels, Rianne; Kooi, Elisabeth M. W.; Bos, Arend F.; Harmsen, Hermie J. M.; Goffau, Marcus C. de

doi:10.1093/cid/ciw016

Cited by 138 publications

(122 citation statements)

References 37 publications

Supporting

Mentioning

113

Contrasting

Unclassified

Order By: Relevance

“…found increasing incidence rates of NEC in the most preterm and low birthweight infants in three centres in the Netherlands, when guidelines changed towards active treatment at lower gestational ages. 222 In contrast to our results, no increase was seen in the term, near term or normal birthweight advances in neonatal care, causing an initial reduction in NEC incidence followed by an increase as the early survival in the population at risk improved, may eventually transition to a phase of stabilised or even decreasing incidence, when some of the prophylactic measures learned along the way gain effect. 9 which is a matter of definition.…”

Section: Variations Over Time and Between Populationscontrasting

confidence: 99%

“…Case-control, N=720 Manually identified, N=200 p n (%) n (%) (222)(223)(224) days respectively. The strongest factor for infants to lack registrations in the NPR, however, was in hospital death.…”

Section: Comparison Of Nec Cases In the Case-control Cohort And Manuamentioning

confidence: 99%

“…231,232 These alterations may predispose to NEC. 222,232,233 In vaginal delivery, colonisation of the infant gut is expected to result from the direct exposure to maternal vaginal and intestinal flora, but it was also found in a small study, that the composition of the microbiome in breast milk differed after elective CS compared to normal labour, 234 indicating a complementary mechanism for colonisation. Moreover, CS has been shown to have a negative impact on breast feeding, 229,235 which could theoretically also contribute to the risk of NEC in term and near-term infants.…”

Section: Risk Factorsmentioning

confidence: 99%

See 2 more Smart Citations

Necrotising Enterocolitis - epidemiology and imaging

Ahle¹

View full text Add to dashboard Cite

Section: Variations Over Time and Between Populationscontrasting

confidence: 99%

Section: Comparison Of Nec Cases In the Case-control Cohort And Manuamentioning

confidence: 99%

Section: Risk Factorsmentioning

confidence: 99%

See 1 more Smart Citation

Necrotising Enterocolitis - epidemiology and imaging

Ahle¹

View full text Add to dashboard Cite

“…In addition, a recent randomized controlled trial on preterm piglets demonstrated sustained administration of antibiotics initiated directly after birth to be protective against NEC [19]. Moreover, in a recent study by Heida et al [20], a NEC-associated gut microbiota composition was already observed to be present in the meconium. These observations, in combination with the absence of any association between the development of NEC and the total number of days treated with antibiotics suggest that, in particular, initial intestinal colonization plays an essential role in the pathogenesis of NEC.…”

Section: Discussionmentioning

confidence: 97%

Risk Factors for Necrotizing Enterocolitis: A Prospective Multicenter Case-Control Study

et al. 2018

View full text Add to dashboard Cite

Background: The identification of independent clinical risk factors for necrotizing enterocolitis (NEC) may contribute to early selection of infants at risk, allowing for the development of targeted strategies aimed at the prevention of NEC. Objective: The objective of this study was to identify independent risk factors contributing to the development of NEC in a large multicenter cohort. Methods: This prospective cohort study was performed in 9 neonatal intensive care units. Infants born at a gestational age ≤30 weeks were included. Demographic and clinical data were collected daily until day 28 postnatally. Factors predictive of the development of NEC were identified using univariate and multivariable analyses in a 1: 5 matched case-control cohort. Results: In total, 843 infants (56 NEC cases) were included in this study. In the case-control cohort, univariate analysis identified sepsis prior to the onset of NEC and formula feeding to be associated with an increased risk of developing NEC, whereas the administration of antibiotics directly postpartum was inversely associated with NEC. In a multivariable logistic regression model, enteral feeding type and the number of days parenterally fed remained statistically significantly associated with NEC, whereas the administration of antibiotics directly after birth was associated with a lower risk of developing NEC. Conclusions: Formula feeding and prolonged (duration of) parenteral feeding were associated with an increased risk of NEC. Contrary to expectations, the initiation of treatment with antibiotics within 24 h after birth was inversely associated with NEC.

show abstract

“…However, recent data prompt reconsideration of this dogma. Mshvildadze et al [1] identified bacterial sequences in freshly produced meconium, as have Heida et al [2], and Ardissone et al [3]. Stout et al [4] have identified bacterial bodies on electron microscopy in the basal plate of placentas delivered via cesarean section.…”

Section: The In-population Of the Human Infant Gut By Microbesmentioning

confidence: 99%

Necrotizing enterocolitis and preterm infant gut bacteria

Warner

Tarr

2016

Seminars in Fetal and Neonatal Medicine

View full text Add to dashboard Cite

Summary Necrotizing enterocolitis remains an intractable consequence of preterm birth. Gut microbial communities, especially bacterial communities, have long been suspected to play a role in the development of necrotizing enterocolitis. Direct-from-stool nucleic acid sequencing technology now offers insights into the make-up of these communities. Data are now converging on the roles of Gram-negative bacteria as causative agents, despite the dynamic nature of bacterial populations, the varying technologies and sampling strategies, and the overall small sample sizes in these case–control studies. Bacteria that confer protection from necrotizing enterocolitis have not been identified across studies. The beneficial effect of probiotics is not apparent in infants with birth weights <1000 g (these infants are at highest risk of, and have the highest case fatality rate from, necrotizing enterocolitis). Further work should be directed to the modulating gut microbes, or the products they produce, to prevent this devastating complication of preterm birth.

show abstract

A Necrotizing Enterocolitis-Associated Gut Microbiota Is Present in the Meconium: Results of a Prospective Study

Abstract: CALIFORNIA trial, registered under trial number NTR4153 in the Dutch Trial Registry.

Cited by 138 publications

References 37 publications

Necrotising Enterocolitis - epidemiology and imaging

Necrotising Enterocolitis - epidemiology and imaging

Risk Factors for Necrotizing Enterocolitis: A Prospective Multicenter Case-Control Study

Necrotizing enterocolitis and preterm infant gut bacteria

Contact Info

Product

Resources

About