A near-infrared light-triggered shape-memory polymer for long-time fluorescence imaging in deep tissues

Chu, Chengzhen; Zhang, Xiang; Wang, Jiao; Xie, Hui; Tao, Xiaxin; Zhou, Shaobing

doi:10.1039/d0tb01237h

Cited by 25 publications

(15 citation statements)

References 50 publications

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“…Compared to shape-memory alloys, these polymers are considered better for stent applications in terms of recoverable strain, processability, cost effectiveness, and tunability of properties [157,163]. Besides temperature-triggered transformations, light-responsive and chemically responsive shape recoveries have been investigated as alternative mechanisms to reduce tissue damage from higher heat transitions [154,[164][165][166][167].…”

Section: Novel Platformsmentioning

confidence: 99%

Cardiovascular Stents: A Review of Past, Current, and Emerging Devices

et al. 2021

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One of the leading causes of morbidity and mortality worldwide is coronary artery disease, a condition characterized by the narrowing of the artery due to plaque deposits. The standard of care for treating this disease is the introduction of a stent at the lesion site. This life-saving tubular device ensures vessel support, keeping the blood-flow path open so that the cardiac muscle receives its vital nutrients and oxygen supply. Several generations of stents have been iteratively developed towards improving patient outcomes and diminishing adverse side effects following the implanting procedure. Moving from bare-metal stents to drug-eluting stents, and recently reaching bioresorbable stents, this research field is under continuous development. To keep up with how stent technology has advanced in the past few decades, this paper reviews the evolution of these devices, focusing on how they can be further optimized towards creating an ideal vascular scaffold.

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Section: Novel Platformsmentioning

confidence: 99%

Cardiovascular Stents: A Review of Past, Current, and Emerging Devices

et al. 2021

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“…[1][2][3][4] At the same time, it has good development and wide application prospects in sensing, coding, photoelectron.etc. [5][6][7][8] Polyurethane is more suitable to be used as matrixes of polymeric fluorescent dye due to its advantages such as adjustable structure, stable performance and diverse processing methods, etc., and is of high interest. [9][10][11][12] Polyurethanebased fluorescent dye is polymeric fluorescent dyes formed by anchoring monomeric fluorescent dye to polyurethane chains by chemical bonds.…”

Section: Introductionmentioning

confidence: 99%

“…This kind of material is not only safe, non‐toxic, very low mobility and permeability, but also has the characteristics of absorption peak width, high quantum yield and stable luminescence performance [1–4] . At the same time, it has good development and wide application prospects in sensing, coding, photoelectron.etc [5–8] …”

Section: Introductionmentioning

confidence: 99%

A Waterborne Polyurethane‐Based Dye with Green Fluorescence Excited by Visible Light

Xian

et al. 2021

ChemistrySelect

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A waterborne aminofluorescein polyurethane-based dye (AF-WPU) with green fluorescence excited by visible light was synthesized by anchoring aminofluorescein (AF) to waterborne polyurethane chains. The structural characteristics of AF-WPU was confirmed by means of 1 H-NMR, FT-IR and UV-vis absorption. Compared with AF, there is a hypsochromic shift, and a new absorption peak generating in the UV-vis spectra of AF-WPU. Meanwhile, AF-WPU emited excellent fluorescence.The fluorescence intensity of AF-WPU increased five times at the same concentration. It is found that the fluorescence intensities of AF-WPU decreaseed with increased temperature, and increased first and then decreased with increasing concentration. The fluorescence of AF-WPU is very stable and insensitive to quenching agents. Moreover, AF-WPU which excited by visible light is less phototoxic to health, and has a broad prospect in practical applications.

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“…Herein, we expect to understand these concerns for the clinically relevant PEG-PCL micelles, 25 since they are the best-characterized systems in preclinical research and showing great potential to successfully enter clinical translational in the near future. 26 We hypothesize that the micelles with different surface PEG density and chain conformation would affect their interactions with the blood components, phagocytosis, and biodistribution once injected into the blood, and finally determine their therapeutic efficiency. To address this hypothesis, PCL n -MPEG micelles that composed of PEG with identical chain length and PCL with tunable chain length (n=20, 30, and 40) were first prepared wherein doxorubicin was encapsulated as a model drug.…”

Section: Introductionmentioning

confidence: 99%

Poly(ϵ-Caprolactone)-Methoxypolyethylene Glycol (PCL-MPEG)-Based Micelles for Drug-Delivery: The Effect of PCL Chain Length on Blood Components, Phagocytosis, and Biodistribution

Hou¹,

Zhou²,

Guo³

et al. 2022

IJN

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Background The main challenge of polymeric micelles as drug delivery systems is that the actual delivery efficiency is not as high as expected, which is closely related with the interactions with the complex biological environments such as blood components, phagocytosis, and biodistribution. Herein, we expect to understand these concerns for the clinically relevant micelles that composed of methoxypolyethylene glycol (MPEG) with identical chain length And poly(ε-caprolactone) (PCL) with tunable chain length (PCL n -MPEG) (n=20, 30, and 40) wherein doxorubicin was encapsulated as a model drug. Methods The doxorubicin-loaded PCL n -MPEG micelles were prepared by a dialysis method and characterized by dynamic light scattering and transmission electron microscopy. The surface PEG density and chain conformation were investigated by dissipative particle dynamics simulation. The stability of the micelles was detected by nanoparticle tracking analysis. The effects of PCL chain length on the blood components, phagocytosis, and biodistribution were assayed in vitro and in vivo. Results The micelles exhibited spherical morphology with a diameter about 30nm. The PEG chain conformation from “mushroom-like” to “brush-like” was evident. The micelles have no remarkable effect on the red blood cells, blood coagulation, and platelet activation. Interestingly, the protein adsorption was affected and dependent on the chain conformation, with lowest adsorption for PCL 30 -MPEG, which also has the loWest phagocytosis. The stability of the micelles was in the order of PCL 40 -MPEG>PCL 30 -MPEG>PCL 20 -MPEG which was dependent on the PCL chain length. The micelles mainly accumulated in liver, with the order consistent with their stability, indicating that, besides the phagocytosis, the stability of the micelle plays an important role in biodistribution as well. The related mechanisms were proposed and discussed. Conclusion Manipulating the PEG/PCL ratio of the micelle is an effective approach to modulate the protein adsorption, phagocytosis, and biodistribution, which may be a prerequisite for clinical applications.

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A near-infrared light-triggered shape-memory polymer for long-time fluorescence imaging in deep tissues

Abstract: How to implant a stent in the body through minimally invasive operation and track its location in real time is still a challenge. Herein, a near-infrared (NIR) light-triggered shape-memory polymer...

Cited by 25 publications

References 50 publications

Cardiovascular Stents: A Review of Past, Current, and Emerging Devices

Cardiovascular Stents: A Review of Past, Current, and Emerging Devices

A Waterborne Polyurethane‐Based Dye with Green Fluorescence Excited by Visible Light

Poly(ϵ-Caprolactone)-Methoxypolyethylene Glycol (PCL-MPEG)-Based Micelles for Drug-Delivery: The Effect of PCL Chain Length on Blood Components, Phagocytosis, and Biodistribution

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