A near-infrared fluorescent probe for monitoring abnormal mitochondrial viscosity in cancer and fatty-liver mice model

Mechanistic analysis of viscosity-sensitive fluorescent probes for applications in diabetes detection

“…Recently, Chao et al synthesised a quinoline-xanthene dye (QX-V)-based NIR-active fluorescent probe for the selective identification and quantification of mitochondrial viscosity. 85 A powerful electron-donating diethylamino group on the xanthene ring underwent strong intramolecular charge transfer (ICT) to the electron-accepting quinolone moiety. In low viscosity healthy cells, the ICT process was hindered due to the facile rotation of the molecular rotor, quinolone ring quenching the fluorescence of the probe; however, with increased viscosity in cancer cells or fatty liver tissues, rotation is restricted, resulting in enhanced fluorescence.…”

Activatable fluorescent probes for early diagnosis and evaluation of liver injury

“…The probe was a positively charged molecule so it could specifically aggregate on electronegative mitochondrial membranes and showed excellent mitochondrial targeting capabilities. 57…”

Development of a novel near-infrared molecule rotator for early diagnosis and visualization of viscosity changes in acute liver injury models

“…The probe demonstrated a significant increase in fluorescence intensity, by approximately 42.8-fold, in response to changes in viscosity from 1.2 cP to 1023 cP. 21 In 2022, Xu group reported a novel viscosity probe based on dicyanoisophorone, designated as NV1. The emission wavelength of probe NV1 is 590 nm.…”