Development of a novel near-infrared molecule rotator for early diagnosis and visualization of viscosity changes in acute liver injury models

Abstract

A novel near-infrared molecule rotator, DJM, was designed and synthesized. This probe exhibited a highly sensitive and selective response to viscosity.

A novel fluorescence probe for simultaneous detection of mitochondrial viscosity in hepatic ischemia reperfusion injury models

“…Currently, fluorescent imaging has garnered notable interest owing to its capability for relatively straightforward operation, high sensitivity, and real-time visualization. 18–21 Therefore, the detection of intracellular viscosity with the aid of a fluorescence spectrometer may become a new-established method, potentially being used for HIRI early diagnosis. To date, considerable and outstanding results have been achieved in imaging viscosity alteration in vivo .…”