2010
DOI: 10.1016/j.biomaterials.2010.05.007
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A near-infrared fluorescent heptamethine indocyanine dye with preferential tumor accumulation for in vivo imaging

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Cited by 236 publications
(215 citation statements)
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“…As shown in Table 1, except the compound 5 synthesized by our laboratory, 9 all the heptamethine indocyanine dyes reported in this work were purchased from American Dye Source Incorporation (ADSL, Quebec, Canada), Sigma-Aldrich Corporation (SAC, Shanghai, China), or Spectrum Information Ltd (SIL, NJ, USA), respectively. These dyes were dissolved in dimethylsulfoxide (DMSO) diluted with appropriate vehicles and stored at À20 C before use.…”
Section: Chemicals and Instrumentsmentioning
confidence: 99%
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“…As shown in Table 1, except the compound 5 synthesized by our laboratory, 9 all the heptamethine indocyanine dyes reported in this work were purchased from American Dye Source Incorporation (ADSL, Quebec, Canada), Sigma-Aldrich Corporation (SAC, Shanghai, China), or Spectrum Information Ltd (SIL, NJ, USA), respectively. These dyes were dissolved in dimethylsulfoxide (DMSO) diluted with appropriate vehicles and stored at À20 C before use.…”
Section: Chemicals and Instrumentsmentioning
confidence: 99%
“…9 Brie°y, three-to fourweek-old athymic nude mice were purchased from the laboratory animal center of the Third Military Medical University. Mice were injected subcutaneously in the right°ank with 2 Â 10 6 MCF-7 cultured cells suspended in 200 ul PBS.…”
Section: Cell Culture and Animal Tumor Modelmentioning
confidence: 99%
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“…¼ 805 nm) wavelengths and high molecular extinction coefficient (e ¼ 27.4 Â 10 4 M À1 cm À1 ) has been adopted so far as a non-targeting contrast agent in clinical and experimental NIR imaging and as a promising second generation photosensitizer in PDT. [36][37][38][39] However, IR-780 as many other hydrophobic cyanines can be disposed to light-induced decomposition (i.e., photobleaching) both in vitro and in vivo resulting in the loss of absorbance, fluorescence, and photoactivity, and thus possibly limiting its use in PDT. 40 In order to increase the potential of hydrophobic cyanines towards improvement of drug efficacy, its stability, and better intracellular penetration, they need to be encapsulated in nanocarriers to avoid any unexpected problems with photoactivity and to improve their dissolution performance by means of encapsulation via template-mediated processes.…”
Section: Introductionmentioning
confidence: 99%
“…40 In order to increase the potential of hydrophobic cyanines towards improvement of drug efficacy, its stability, and better intracellular penetration, they need to be encapsulated in nanocarriers to avoid any unexpected problems with photoactivity and to improve their dissolution performance by means of encapsulation via template-mediated processes. 27,37 The main objective of this work is a basic research focused on examination of the mechanism and effectiveness of the introduction of a photosensitizer to carcinoma cells in the form of nanocarriers such as PE nanocapsules and then performing cytotoxicity tests during photodynamic therapy based on the use of model conditions and designed system lab-on-a-chip. Newly encapsulated hydrophobic indocyanine-type photosensitizer (i.e., IR-780) was subjected to in vitro studies to determine its release characteristics on a molecular level.…”
Section: Introductionmentioning
confidence: 99%