A Natural Wonder Drug Helps to Prevent Cancer: Garlic Oil

Mirunalini, Sankaran; Dhamodharan, Ganesan; Karthishwaran, Kandhan

doi:10.15835/nsb213593

Cited by 7 publications

(5 citation statements)

References 25 publications

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“…Garlic oil has been known to scavenge free radicals and reduce lipid peroxidation (Mirunalini et al, 2010). Nencini et al (2010) reported increases in GSH and CAT levels with orally administered garlic homogenates (250 mg/kg of BW) in rats with liver injury.…”

Section: Oxidative Stressmentioning

confidence: 99%

Host-mediated effects of phytonutrients in ruminants: A review

Wall²,

Bravo³

et al. 2017

Journal of Dairy Science

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Plants produce an extensive array of organic compounds derived from secondary metabolism that may be useful in animal nutrition because of their chemical makeup. These plant-derived bioactive compounds, also referred to as phytonutrients (PN) or phytobiotics, have been shown to express antimicrobial activities against a wide range of bacteria, yeast, and fungi and have been investigated as rumen modifiers in ruminant nutrition. Studies have reported that PN may inhibit deamination of AA and methanogenesis in the rumen and shift fermentation toward propionate and butyrate. Most of the experiments, however, have been conducted in vitro, and responses have been highly variable and inconsistent in animal experiments. In addition, some studies have reported that PN had positive effects on productivity, although rumen fermentation was not affected. Other than antimicrobial effects in the gut, PN are known to bind specific receptors expressed in neurons, intestines, and other cells and exhibit related physiological effects in nonruminants. The receptor-mediated effects include immune responses, oxidative stress, and insulin secretion and activity. Some PN, due to their phenolic nature, are likely less susceptible to microbial degradation in the rumen and may exhibit activities postruminally, similar to their mode of action in nonruminant species. This opens a new area of research in ruminants, including effects of PN on the animal's immune system, postruminal nutrient use, and animal physiology. Although limited, studies with ruminants provide first evidence of PN's regulatory effects on the host responses. For example, PN were reported to regulate immune cells related to adaptive and innate immunity in challenged or nonchallenged dairy cows. Supplementation of PN reduced oxidative stress by decreasing lipid peroxidation and increasing endogenous antioxidants in ruminants. Additionally, insulin secretion and sensitivity were reportedly regulated by PN in dairy cows. The regulatory effects of PN on immunity may be beneficial for immune suppression and inflammation in dairy cows. In addition, PN could positively affect energy partitioning for milk production through their effects on insulin secretion and sensitivity. Further research is needed to elucidate the effect and mode of action of PN on immune function and animal energetics.

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Section: Oxidative Stressmentioning

confidence: 99%

Host-mediated effects of phytonutrients in ruminants: A review

Wall²,

Bravo³

et al. 2017

Journal of Dairy Science

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“…The beneficial anticarcinogenic and immunomodulatory effects of the agents in garlic [ 23 ], that is, water- and lipid-soluble allyl sulfides, can influence a number of molecular events involved in cancer, such as inhibiting mutagenesis, blocking carcinogen DNA adduct formation, scavenging free radicals, and blocking cell proliferation, differentiation, and angiogenesis. Although there is a large body of evidence supporting each of these and other mechanisms, there is a need for additional research to demonstrate whether these changes are causally related to cancer-preventive activity.…”

Section: Discussionmentioning

confidence: 99%

Long‐Term Treatment with Aqueous Garlic and/or Tomato Suspensions Decreases Ehrlich Ascites Tumors

Bom

Gunutzmann

Hurtado

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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We evaluated the preventive and therapeutic effects of aqueous suspensions of garlic, tomato, and garlic + tomato in the development of experimental Ehrlich tumors in mice. The aqueous suspensions (2%) were administered over a short term for 30 days before tumor inoculation and 12 days afterward, and suspensions at 6% were administered for 180 days before inoculation and for 12 days afterward. The volume, number, and characteristics of the tumor cells and AgNOR counts were determined to compare the different treatments. Aqueous 6% suspensions of garlic, tomato, and garlic + tomato given over the long term significantly reduced tumor growth but when given over the short term, they did not alter tumor growth.

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“…"C. indica is rich in protein, lipids, mineral, fiber, carbohydrates and is abundant with essential amino acids" [2]. Mirunalini et al, [3] and Babu and Rao [4] "Nutritive value of milky mushroom is comparable with other mushrooms, mature fruiting body of Calocybe indica contains higher proteins. It contains all the amino acids, out of which glycine is predominant.…”

Section: Introductionmentioning

confidence: 99%

Comparative Studies on Nutritional and Phytochemical Composition of Three Milky Mushroom Varieties

Prameela M.,

Kumari A. J.

2023

IJECC

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Milky mushroom (Calocybe indica P&C) is a tropical potentially new species gaining popularity and demand by the mushroom growers especially in South India.As biochemical composition of milky mushrooms are influenced by the growing environmental conditions, research pertaining to these aspects is very meagre and also to compare the nutritional and biochemical composition of three milky mushroom species so that the best species can be selected by the growers, hence the present research work has been taken up to estimate the concentration of proteins, carbohydrates and phytochemical compounds like phenols, flavonoids, alkaloids and tannins in three varieties of milky mushrooms namely Calocybe indica, Calocybe gambosa and APK-2 in Mushroom Cultivation Scheme, Department of Plant Pathology, Hyderabad. The results revealed the presence of highest protein and carbohydrates content in Calocybe indica (15.9g, 2.7g) followed by APK-2 (11.2g and 2.1g) and C. gambosa (10.0g and 1.6g) and highest fats in APK-2 (2.0g), followed by C. gambosa(1.4g) and least in C. indica (1.3g) respectively. The secondary metabolites phytochemicals like phenols and tannins were highest content in C. indica (2.3 gm, 1.9mg) followed by C. gambosa (2.2gm, 1.6 mg) and next followed by APK-2 (2.1 gm, 1.5mg). Highest flavonoid content was recorded in C. indica and APK-2 of 1.5mg and least was recorded in C. gambosa of 1.4mg. Highest content of alkaloid was recorded in C. indica of 1.8mg, followed by APK-2 (1.6mg) and C. gambosa (1.5mg).

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A Natural Wonder Drug Helps to Prevent Cancer: Garlic Oil

Cited by 7 publications

References 25 publications

Host-mediated effects of phytonutrients in ruminants: A review

Host-mediated effects of phytonutrients in ruminants: A review

Long‐Term Treatment with Aqueous Garlic and/or Tomato Suspensions Decreases Ehrlich Ascites Tumors

Comparative Studies on Nutritional and Phytochemical Composition of Three Milky Mushroom Varieties

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