A Natural Material for Suppressing the Effects of Oxidative Stress: Biological Activities of Alcea kurdica

Mohammed, Falah Saleh; Sevindik, Mustafa; Uysal, İmran; Sevindik, Emre; Akgül, Hasan

doi:10.1134/s1062359022140102

Cited by 21 publications

(20 citation statements)

References 30 publications

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“…Although antibiotic use is required for the treatment of these bacteria, the development of antibiotic resistance is the most important factor in treatment failure (Seow et al, 2013;Sevindik et al, 2017). Concerns about consumers' negative perceptions of chemical preservatives have encouraged the food industry to look for new and reliable alternatives, and natural preservatives have begun to be developed (Güner et al, 2012;Seow et al, 2013;Mohammed et al, 2018;Pehlivan and Sevindik, 2018).…”

Section: Introductionmentioning

confidence: 99%

Determination of Antimicrobial Activity of Different Essential Oils Obtained from Plants on Staphylococcus aureus Strains Isolated from Foods

Canberi

Şentürk

Aktop

et al. 2020

Turkish JAF Sci.Tech.

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Essential oils (EOs) are known for its antimicrobial activity against several pathogenic bacteria. The present work evaluated the antimicrobial activity of 15 different EOs on survival of different strains of different Staphyloccocus aureus strains isolated from traditional cheeses by disc diffusion method. The most antimicrobial activity on the strains was found as oil thyme oil (mean zone diameter 23.203 mm). Clove oil and black seed oil had the highest antimicrobial activity after thyme oil with average zone diameters of 13.698 mm and 11.267 mm respectively. Hypericum perforatum L. oil (mean zone 6.209 mm), ginger oil (mean zone 6.250 mm) and garlic oil (mean zone 6.267 mm) were the lowest antimicrobial activity. New studies about antimicrobial effect of EOs in vivo conditions are recommended.

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Section: Introductionmentioning

confidence: 99%

Determination of Antimicrobial Activity of Different Essential Oils Obtained from Plants on Staphylococcus aureus Strains Isolated from Foods

Canberi

Şentürk

Aktop

et al. 2020

Turkish JAF Sci.Tech.

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“…TAS values of Satureja hortensis (TAS:5.403, TOS:3.537, OSI:0.065), Thymbra spicata (TAS:8.399, TOS:6.530, OSI:0.078), Salvia absconditiflora (TAS:7.350, TOS:8.501, OSI:0.116), Rumex scutatus(TAS:8.656, TOS:4.951, OSI:0.057), Alcea kurdica(TAS:3.298, TOS:8.312, OSI:0.252), Mentha longifolia subsp. longifolia (TAS:3.268, TOS:4.046, OSI:0.112) and Glycyrrhiza glabra (TAS:8.770, TOS:14.509, OSI:0.167) have been reported in studies on different plant species (Sevindik et al, 2017;Mohammed et al, 2019b;Akgul et al, 2020;Mohammed et al, 2020;Mohammed et al, 2021;Mohammed et al, 2022;Unal et al, 2022). In these tests, the TAS value of white radish tubers was lower than those of T. spicata, R. scutatus, S. abscondita, and G. glabra, and higher than those of S. hortensis, A. kurdica, and M. longifolia subsp.…”

Section: Antioxidant and Oxidant Activitymentioning

confidence: 95%

“…Many people nowadays utilise natural products as part of their alternative or supplementary healthcare routines (Mohammed et al, 2018). Medicinal, nutritional, preservative, and flavouring applications are just some of the many uses for these all-natural ingredients (Sevindik, 2018).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and antimicrobial activities of White Radish

Sevindik

Onat²,

Mohammed

et al. 2023

Turkish JAF Sci.Tech.

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Since prehistoric times, humans have relied on plants for a wide variety of needs, including sustenance, shelter, thermal regulation, and medical treatment. Plants are significant organics because of the many ways they may be put to use. The white radish (Raphanus raphanistrum subsp. sativus (L.) Domin) was tested for its antioxidant and antibacterial properties, as were its tuber and aerial portions. A soxhlet was used to extract ethanol from plant material. The antioxidant and oxidant capacities were tested with the use of Rel Assay TAS and TOS kits. The agar dilution technique was used to test for antimicrobial activity against the bacteria and fungus included in the experiment. As a result of the studies, the TAS value of the tuber extract of the plant was measured as 6.698±0.187, the TOS value as 5.609±0.245 and the OSI value as 0.084±0.002. The TAS value of the herbal aerial parts extract was 4.689±0.223, the TOS value was 3.746±0.128, and the OSI value was 0.080±0.003. Inhibition of tuber extract was observed at concentrations varying between 25-100 against bacterial strains and 200 µg/mL against fungal strains. Aerial parts extract showed inhibition against bacterial strains at concentrations varying between 100-200 and against fungus strains at concentrations ranging from 200-400 µg/mL. As a result, it was determined that the white radish plant has significant antioxidant and antimicrobial activity.

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“…TOS verileri sırayla 12.144; 16.288; 5.170; 4.046; 6.294; 22.441 ve 6.53 µmol/l şeklinde gösterilmiştir. OSİ verileri sırayla 0.211; 0.278; 0.071; 0.112; 0.138; 0.349 ve 0.07 şeklinde gösterilmiştir [38][39][40][41][42][43]. Araştırmamızdaki OSİ verileri yukarıdaki araştırmalara nazaran daha düşük seviyede olduğu gözlemlekmektedir.…”

Section: şEkil 7 Oksiresveratrolün Proliferatif Değişimiunclassified

Positive Effects of Oxyresveratrol on Oxidative Stress Damage in L929 Fibroblast Cells

ATES>

Bayır

2023

Ankara Ecz. Fak. Derg.

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Amaç: L929 fibroblast hücrelerinde H2O2 etkisiyle oluşturulan hücre hasarının bertaraf edilmesinde oksiresveratrolün rejeneratif etkisinin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Oksiresveratrolün total antioksidan seviyesi (TAS), total oksidan seviyesi (TOS), oksidatif stres indeksi (OSİ), toplam fenolik madde seviyeleri farklı derişimlerde ölçülmüştür. Oksiresveratrol fibroblast hücrelerinde IC50 değeri MTT yöntemiyle belirlenmesinin ardından 12.5 - 400 µM konsantrasyonlarında H2O2 ile meydana getirilen oksidatif stres hasarındaki rejeneratif etkisi in-vitro ortamdaki hücre proliferasyonunun ölçümü xCELLigence cihazıyla gerçekleştirilmiştir. Ayrıca hücre hasarındaki yara iyileşme düzeylerini belirlemek amacıyla 3.125 - 25 µM derişimlerinde scratch analizi yapılmıştır. Sonuç ve Tartışma: Oksiresveratrolün 0.5 mg/ml’de TAS değeri 3 ± 0.3 ve TOS değeri 0.77 ± 0.52; (OSİ) değeri 0.02 ± 0.09 olarak bulunmuştur. Oksiresveratrolün 0.625 mg/ml’den 10 mg/ml’ye farklı dozlarındaki total fenolik madde (TFM) derişimleri düşük konsantrasyondan yüksek konsantrasyona daha yüksek TFM’ye sahip olduğu gözlemlenmiştir. Oksiresveratrolün L929 fibroblast hücreleri IC50 değeri 214.2 μM; H2O2’e maruz bırakılan L929 fibroblast hücrelerindeki hücre hattında oksiresveratrol IC50 değeri 109.7 μM olduğu belirlenmiştir. Oksiresveratrolün 12.5 μM konsantrasyonunun xCELLigence cihazıyla ölçülmesinde en fazla hücre proliferasyonu gözlenmiştir. Scratch analizinde H2O2 ile hasarlanmış hücrelerdeki 12.5 μM oksiresveratrol konsantrasyonunda 24. Saat için %62, 48. Saat için %88’lik bir hücre proliferasyonuyla diğer dozlardan daha fazla iyileşme gözlenmiştir. 12.5 μM konsantrasyonu hem proliferasyon, hem de scratch analizinde en etkili konsantrasyon olduğu belirlenmiştir. Oksiresveratrol; düşük konsantrasyonlarda gösterdiği antioksidan kapasiteyle H2O2 aracılığıyla meydana getirilen hücresel hasarda, L929 fibroblast hücrelerini oksidatif stresten korur, fibroblast canlılığına ve migrasyona bir güç çarpanı etkisi oluşturur. Bu sonuçlar oksiresveratrolün; serbest oksijen radikallerinin oluşturduğu akut ya da kronik hastalıkların engellenmesinde hücre düzeyinde etkili olabileceğini göstermiştir. Hücre düzeyinde gerçekleştirilecek daha kapsamlı çalışmalar, in-vivo çalışmalarla oksidatif stres kaynaklı hastalıkların tedavisinde oksiresveratrolün potansiyel bir molekül olabileceği düşünülebilir.

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A Natural Material for Suppressing the Effects of Oxidative Stress: Biological Activities of Alcea kurdica

Cited by 21 publications

References 30 publications

Determination of Antimicrobial Activity of Different Essential Oils Obtained from Plants on Staphylococcus aureus Strains Isolated from Foods

Determination of Antimicrobial Activity of Different Essential Oils Obtained from Plants on Staphylococcus aureus Strains Isolated from Foods

Antioxidant and antimicrobial activities of White Radish

Positive Effects of Oxyresveratrol on Oxidative Stress Damage in L929 Fibroblast Cells

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