A natural dye, Niram improves atopic dermatitis through down-regulation of TSLP

Han, Ning; Park, Jin‐Young; Jang, Jae-Bum; Jeong, Hyun‐Ja; Kim, Hyung-Min

doi:10.1016/j.etap.2014.10.011

Cited by 11 publications

(3 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…39 We also reported that expression of mast cell-derived caspase-1 was suppressed by Polygonum tinctorium in atopic dermatitis-like lesional skin. 40 In the present study, A. hookeri and RU significantly decreased mast cell-derived caspase-1 expression and activity in our AR animal model. These results indicated that A. hookeri and RU decreased AR by blocking the caspase-1 pathway.…”

Section: Discussionsupporting

confidence: 54%

Protective Effects of Rutin through Regulation of Vascular Endothelial Growth Factor in Allergic Rhinitis

Kim

Nam

Hong

et al. 2015

Am J Rhinol�Allergy

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 54%

Protective Effects of Rutin through Regulation of Vascular Endothelial Growth Factor in Allergic Rhinitis

Kim

Nam

Hong

et al. 2015

Am J Rhinol�Allergy

Self Cite

View full text Add to dashboard Cite

show abstract

“…It has also been used in traditional medicine for the improvement of atopic dermatitis (Han et al, 2014), antioxidant (Tokuyama-Nakai et al, 2018), anti-inflammatory (Micallef et al, 2002), anticancer (Jang et al, 2012), anti-HIV (Zhong et al, 2005), antibacterial (Kataoka et al, 2001), antidermatophytic (Honda et al, 1980), and antifungal effect (Honda & Tabata, 1979).…”

Section: Introductionmentioning

confidence: 99%

Enhancement of shoot organogenesis in Polygonum tinctorium by sucrose and gelling agents

Park

Kil

2022

View full text Add to dashboard Cite

Indigo (Polygonum tinctorium), though it is a medicinal and dye crop, can also be grown in temperate areas, especially because it is commonly disseminated in Japan. To date, much research has been considered under investigation, especially for the regeneration of the indigo plant. Here in this study, we investigated the response of sucroses and gelling agents on the shoot organogenesis of the indigo plant. Micropropagation in terms of shoot regeneration and its growth was highly responded to sucrose and gelling agents. While culturing of internode explants on initial shoot regeneration media supplemented with sucrose and gelling agents of phytagar and gelrite significantly upgraded the regeneration efficiency as well as shoot growth. The regeneration capacity of the shoot was augmented with increased levels of sucrose up to 40 g L-1 and then started to decrease, whereas the increasing pattern continued even at the highest concentration (50 g L-1). The highest shoot regeneration (6.0 ± 0.5) was achieved by the treatment of 40 g L-1 giving 7.5 times higher shoot regeneration compared to the control. The increasing pattern for shoot length was more pronounced than that of shoot regeneration. The shoot length ranged from 10.2 mm to 23.5 mm within the sucrose treatments. In this study, the highest shoot length (23.5± 0.21) was observed by the treatment of 50 g L-1 exhibiting 2.3 times higher shoot length compared to the control. Gelling agent gelrite performed better than phytagar for both regeneration and shoot length growth. The shoot regeneration among the phytagar treatments ranged from 3.8 to 6.0 shoots/explant whereas the shoot regeneration ranged from 6.6 to 7.2 among the gelrite treatments. The highest shoots/explant (7.2) and the longest shoot length (22.4 mm) were observed due to the treatment of gelrite 3. The lowest shoot regeneration and shoot length were denoted when phytagar 9 was applied. It is proposed from our study that sucrose and gelling agent especially gelrite 3 could be applied in shoot organogenesis and plant transformation of any plant species, especially for P. tinctorium.

show abstract

“…10 However, owing to their many side effects, interest in natural anti-inflammatory agents as alternative medicines is increasing. 11,12 Inflammation can be mitigated by H 1 antihistamine, which attenuates the expression of nuclear factor κB, a transcription factor that regulates inflammatory processes. 13 In addition, AD patients are more susceptible to reactive oxygen species (ROS) and oxidants, which reduce enzymatic and nonenzymatic antioxidants.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional chitosan-coated poly(lactic-co-glycolic acid) nanoparticles for spatiotemporally controlled codelivery of ceramide and C-phycocyanin to treat atopic dermatitis

Min

Lee

Song

et al. 2019

Journal of Bioactive and Compatible Polymers

View full text Add to dashboard Cite

Atopic dermatitis is an inflammatory disease associated with defective skin barrier. The co-administration of a lipid-enhancing skin barrier composed of ceramide with an anti-inflammatory agent is required to effectively treat atopic dermatitis. As atopic dermatitis treatment is affected by the dosage and frequency of medication, the development of nanoparticles that have long-term efficacy with a single dose would be advantageous. In this study, skin-sensitive chitosan nanoparticles codelivering ceramide and C-phycocyanin were developed to provide anti-inflammatory effects with no cytotoxicity, and their effect on stratum corneum formation in a rat atopic dermatitis model was examined. Analysis of the messenger RNA expression of keratinization factors demonstrated that the stratum corneum–formation effect of poly(lactic-co-glycolic acid) nanoparticles containing ceramide was similar to or higher than that of ceramide alone. Compared to the nanoparticles without C-phycocyanin, nanoparticles coated with C-phycocyanin and chitosan attenuated histamine release. In addition, despite frequent washing, the nanoparticles were well fixed to the epidermis after their administration. The results suggest that a single treatment with the combination of lipid therapy/anti-inflammatory nanoparticles is a convenient and high-efficiency means to increase stratum corneum formation in atopic dermatitis patients.

show abstract

A natural dye, Niram improves atopic dermatitis through down-regulation of TSLP

Cited by 11 publications

References 39 publications

Protective Effects of Rutin through Regulation of Vascular Endothelial Growth Factor in Allergic Rhinitis

Protective Effects of Rutin through Regulation of Vascular Endothelial Growth Factor in Allergic Rhinitis

Enhancement of shoot organogenesis in Polygonum tinctorium by sucrose and gelling agents

Multifunctional chitosan-coated poly(lactic-co-glycolic acid) nanoparticles for spatiotemporally controlled codelivery of ceramide and C-phycocyanin to treat atopic dermatitis

Contact Info

Product

Resources

About