A natural compound induced cardiogenic differentiation of endogenous MSCs for repair of infarcted heart

Lin, Xiaojun; Peng, Peng; Cheng, Lei; Chen, Shihui; Li, Karen; Li, Zhong Yu; Mo, Ye Hua; Zhou, Zhen; Li, Ming

doi:10.1016/j.diff.2011.09.001

Cited by 21 publications

(31 citation statements)

References 29 publications

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“…Coculture protocols with neonatal rat ventricular myocytes highlighted the cardiogenic potential of BM-MSCs, suggesting the influence of soluble factors [54]. Studies in rat models showed the efficiency of both intravenously-injected BM-MSCs and endogenous BM-MSCs in homing and regenerating myocardium under the oral administration of cardiogenin, a natural active compound extracted from Geum japonicum, even if the use of exogenous BM-MSCs may be associated with the risks related to dangerous intramyocardial injection, as well as possible immune rejection response, and the oral administration of cardiogenin is not yet studied at pharmacodynamic and pharmacokinetic level for clinical therapy [55]. In a similar way, rat adipose-derived MSCs (ACSs) treated with phorbolmyristate acetate, a protein kinase C (PKC) activator, showed the expression of cardiacspecific markers (such as cardiac troponin T, myosin light chain, myosin heavy chain) and a reduction of infarct size, interstitial fibrosis, and apoptotic index, suggesting a possible role in restoration of electromechanical function in infarcted rat hearts [56].…”

Section: Bone Marrow and Adipose-derived Mes-enchymal Stem Cellsmentioning

confidence: 99%

New Frontiers in Regenerative Medicine in Cardiology: The Potential of Wharton’s Jelly Mesenchymal Stem Cells

Corrao¹,

Rocca²,

Iacono³

et al. 2013

CSCR

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Cardiomyopathies are still the first cause of death in the world. The identification of resident stem cells, comprising those derived from sub-endocardial stroma, suggests the possible self regeneration of the heart under autocrine/paracrine modulation in the cardiac microenvironment. Nevertheless, because of the limited in vivo regeneration potential of damaged cardiac tissue, the use of drugs and ultimately cardiac transplantation remain the common treatments of heart diseases and defects. The differentiative potential of embryonic and mesenchymal stem cells (MSCs) derived from different tissues (such as bone marrow and adipose tissue) was extensively explored in cell therapy for regenerative medicine. Many groups have been focused, in recent years, on isolation, characterization, and differentiation potential of MSCs derived from perinatal (or extraembryonic) tissues, mainly the placenta and the human umbilical cord. In this review, we summarized recent works about the stemness of Wharton's jelly stromal cells and their potential in cardiac regeneration with favourable use in cell therapy and regenerative medicine. The peculiar features of these cells, as the expression of cardiac-specific transcription factors and immunomodulatory molecules suggest that human umbilical cord may be considered as a reliable alternative source of MSC useful for advanced therapy in cardiac regenerative medicine.

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Section: Bone Marrow and Adipose-derived Mes-enchymal Stem Cellsmentioning

confidence: 99%

New Frontiers in Regenerative Medicine in Cardiology: The Potential of Wharton’s Jelly Mesenchymal Stem Cells

Corrao¹,

Rocca²,

Iacono³

et al. 2013

CSCR

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“…4a–d). In the sea urchin mesenchyme blastula, the non-skeletogenic mesoderm, together with the endoderm, locates superficially at the vegetal pole as well, reminiscent of the situation in amphibians [8, 57]. Of the known SM marker genes in the frog, foxj1 [58–60], nodal3 [58] and wnt11b [61], only foxj1 has been analyzed in sea urchins (Fig.…”

Section: Discussionmentioning

confidence: 99%

Cilia are required for asymmetric nodal induction in the sea urchin embryo

et al. 2016

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BackgroundLeft-right (LR) organ asymmetries are a common feature of metazoan animals. In many cases, laterality is established by a conserved asymmetric Nodal signaling cascade during embryogenesis. In most vertebrates, asymmetric nodal induction results from a cilia-driven leftward fluid flow at the left-right organizer (LRO), a ciliated epithelium present during gastrula/neurula stages. Conservation of LRO and flow beyond the vertebrates has not been reported yet.ResultsHere we study sea urchin embryos, which use nodal to establish larval LR asymmetry as well. Cilia were found in the archenteron of embryos undergoing gastrulation. Expression of foxj1 and dnah9 suggested that archenteron cilia were motile. Cilia were polarized to the posterior pole of cells, a prerequisite of directed flow. High-speed videography revealed rotating cilia in the archenteron slightly before asymmetric nodal induction. Removal of cilia through brief high salt treatments resulted in aberrant patterns of nodal expression. Our data demonstrate that cilia - like in vertebrates - are required for asymmetric nodal induction in sea urchin embryos.ConclusionsBased on these results we argue that the anterior archenteron represents a bona fide LRO and propose that cilia-based symmetry breakage is a synapomorphy of the deuterostomes.Electronic supplementary materialThe online version of this article (doi:10.1186/s12861-016-0128-7) contains supplementary material, which is available to authorized users.

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“…More importantly, AFGJ-induced growth of coronary collaterals into the ischemic region of CHD hearts should address the root pathology of the disease and provide a novel therapeutic method for effective/curative treatment of chronic CHD. In addition to the effect of EGJ or AFGJ on the stimulation of substantial growth of coronary collateral vessels in ischemic hearts, several other studies also demonstrated that another active fraction identified/isolated from EGJ showed the property in stimulating myocardial regeneration in an acute MI animal model through topical injection (0.3 mg) or intragastric administration (300-500 mg/kg body weight) [13,94,98,99]. These findings prompted further investigations for the identification and isolation of the active component from the fraction and demonstration of the activity of the active component.…”

Section: Potentiating Mechanisms Of Inherited Cardiacmentioning

confidence: 97%

Plants and Their Bioactive Compounds with the Potential to Enhance Mechanisms of Inherited Cardiac Regeneration

Zhou

Li²,

Zhou

et al. 2015

Planta Med

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!This article reviews the current progress and research indications in the application of natural plant compounds with the potential for the treatment of cardiovascular diseases. Our understanding of how to apply natural plant compounds to enhance mechanisms of inherited cardiac regeneration, which is physiologically pertinent to myocyte turnover or minor cardiac repair, for substantial cardiac regeneration to repair pathological heart injuries is discussed. Although significant progress has been made in the application of natural plant compounds for therapy of heart diseases, the understanding or the application of these compounds specifically for enhancing mechanisms of inherited cardiac regeneration for the treatment of cardiovascular diseases is little. Recent recognition of some natural plant compounds that can repair damaged myocardial tissues through enhancing mechanisms of inherited cardiac regeneration has offered an alternative for clinical translation. Application of natural plant compounds, which show the activity of manipulating gene expressions in such a way to enhance mechanisms of inherited cardiac regeneration for cardiac repair, may provide a promising strategy for the reconstruction of damaged cardiac tissues due to cardiovascular diseases.

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A natural compound induced cardiogenic differentiation of endogenous MSCs for repair of infarcted heart

Cited by 21 publications

References 29 publications

New Frontiers in Regenerative Medicine in Cardiology: The Potential of Wharton’s Jelly Mesenchymal Stem Cells

New Frontiers in Regenerative Medicine in Cardiology: The Potential of Wharton’s Jelly Mesenchymal Stem Cells

Cilia are required for asymmetric nodal induction in the sea urchin embryo

Plants and Their Bioactive Compounds with the Potential to Enhance Mechanisms of Inherited Cardiac Regeneration

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