Plants and Their Bioactive Compounds with the Potential to Enhance Mechanisms of Inherited Cardiac Regeneration

Abstract

!This article reviews the current progress and research indications in the application of natural plant compounds with the potential for the treatment of cardiovascular diseases. Our understanding of how to apply natural plant compounds to enhance mechanisms of inherited cardiac regeneration, which is physiologically pertinent to myocyte turnover or minor cardiac repair, for substantial cardiac regeneration to repair pathological heart injuries is discussed. Although significant progress has been made in the application of natural plant compounds for therapy of heart diseases, the understanding or the application of these compounds specifically for enhancing mechanisms of inherited cardiac regeneration for the treatment of cardiovascular diseases is little. Recent recognition of some natural plant compounds that can repair damaged myocardial tissues through enhancing mechanisms of inherited cardiac regeneration has offered an alternative for clinical translation. Application of natural plant compounds, which show the activity of manipulating gene expressions in such a way to enhance mechanisms of inherited cardiac regeneration for cardiac repair, may provide a promising strategy for the reconstruction of damaged cardiac tissues due to cardiovascular diseases.

Structural characteristics, bioavailability and cardioprotective potential of saponins

“… 75 Interestingly, the cardiac tissue regeneration effect has also been studied for few saponins e. g. ginsenoside Rg1 and Rb1, tanshinone IIA, astragaloside IV, salvianolic acid B, and cardiogenin (Niga-ichigoside F1). 76 The cardiac regeneration activity of saponins can be used as a tool for the effective treatment of injured hearts and other body organs. 77 …”

The Metabolic Plant Feedback Hypothesis: How Plant Secondary Metabolites Nonspecifically Impact Human Health

“…Such model assessments can reveal the effects of plant-derived secondary metabolites on specific tissue functions in a genetic population. It cannot be ignored that a very high number of plant extracts in controlled laboratory studies seem to exert beneficial effects on inflammatory and metabolic diseases by largely unknown mechanisms [89][90][91][92][93][94][95][96]. Strikingly, it appears that almost any plant extract is somehow effective.…”