A natural antiviral and immunomodulatory compound with antiangiogenic properties

Virucidal, antiviral and immunomodulatory activities of β-escin and Aesculus hippocastanum extract

“…No significant differences between IL‐6 release from untreated and β‐escin and AH‐treated cells were detected. As expected, IL‐6 production was higher in HSV‐1‐infected cells than in uninfected cells . Nevertheless, β‐escin and AH significantly increased IL‐6 production when added to HSV‐1‐infected cells (Figure c).…”

“…On the other hand, angiogenesis represents a major step in HSK pathogenesis. [2,26] Taken into account that b-escin and AH display anti-angiogenic activity in vitro and in vivo conditions, [15] together with their virucidal, antiviral and immunomodulatory activities reported here, we believe that b-escin and AH would become a promising therapy to control the progress of HSK.…”

“…As expected, IL-6 production was higher in HSV-1-infected cells than in uninfected cells. [20,25,26] Nevertheless, b-escin and AH significantly increased IL-6 production when added to HSV-1-infected cells (Figure 3c). In summary, bescin and AH enhanced the activation of the NF-jB and AP-1 signalling pathways, and consequently the release of IL-6, in HSV-1-infected epithelial cells of ocular origin.…”

In vitro antiviral effect of ethanolic extracts from Azadirachta indica and Melia azedarach against goat lentivirus in colostrum and milk

“…In 1998, Castilla et al 57 inhibited the multiplication of the Junin virus using meliacine peptide. More recent findings have demonstrated that extracts from chinaberry trees affect DNA synthesis, maturation, and egress of HSV-1 58 , 59 and inhibit viral multiplication of HSV-2 26 . In addition, fruit extracts of M. azedarach inactivated dengue virus, yellow fever virus, and West Nile virus 60 .…”

Plant natural products: from traditional compounds to new emerging drugs in cancer therapy

“…Also metabolites derived from plants may possess pro‐apoptotic properties and have great potential for possible applications in cancer prevention, such as extracts of Solanum muricatum (Pepino) . Meliacine (MA), a substance present in leaf extracts of Melia azedarach L ., reduces viral load and abolishes inflammatory reactions and neovascularization, displays anti‐herpetic and immunomodulatory activities, impedes VEGF transcription, and therefore interferes with the angiogenic process . Methanolic extract of Rhizophora apiculata has been evaluated by using B16F‐10 melanoma‐induced lung metastasis model in C57BL/6 mice, indicating that natural products can affect the metastatic process .…”