Plant natural products: from traditional compounds to new emerging drugs in cancer therapy

Ouyang, Liang; Luo, Yue; Tian, Min; Zhang, S.-Y.; Lu, Ruifeng; Wang, J.-H.; Kasimu, Rena; Li, Xianchan

doi:10.1111/cpr.12143

Cited by 122 publications

(81 citation statements)

References 81 publications

(85 reference statements)

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“…However, alkaloids have long been existed before humans; some of them are structurally similar to neurotransmitters present in the central nervous system of humans. Considering the medicinal importance of alkaloids and research explaining their role in treating wild propagation of cells, they would be used as an effective chemopreventive agent in the era of modern drug innovation (63,64). Amaryllidaceae alkaloids, betalain alkaloids, diterpenoid alkaloids, indole alkaloids, isoquinoline alkaloids, lycopodium alkaloids, monoterpene and sesquiterpene alkaloids, peptide alkaloids, pyrrolidine and piperidine alkaloids, pyrrolizidine alkaloids, quinoline alkaloids, quinolizidine alkaloids, steroidal alkaloids, tropane alkaloids, and miscellaneous alkaloids are the main categories of Alkaloids.…”

Section: Alkaloidsmentioning

confidence: 99%

Phytochemicals in Cancer Prevention: A Review of the Evidence

et al. 2017

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Context: Cancer generally is considered as a neoplastic disease with particular causative and etiologic factors as well as protective elements. Although it has remained difficult to treat, it is preventable. Recently, the interest in dietary phytochemicals intake has considerably increased for potential cancer chemoprevention.Evidence Acquisition: This report reviews the role of phytochemical consumption in cancer prevention based on publications from PubMed, Science direct, Google Scholar, and Scopus from the year 1996 onward using cancer, chemoprevention, phytochemical keywords.Results: Regular intake of phytochemicals has been demonstrated to prevent cancer during its different stages including initiation, promotion and progression. Considering the animal models, the second step is the main stage for cancer chemoprevention. Conclusions:The phytochemicals involved in chemoprevention can be categorized in different groups naming phenolics, carotenoid, alkaloids, organosulfur compounds and nitrogen-containing compounds. They are able to stop, postpone and reverse carcinogenesis by different mechanisms.

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Section: Alkaloidsmentioning

confidence: 99%

Phytochemicals in Cancer Prevention: A Review of the Evidence

et al. 2017

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“…To date, many of the anticancer agents currently used in cancer therapies have been developed from natural products such as plants (vincristine, vinblastine, etoposide, paclitaxel, camptothecin, topotecan, and irinotecan), marine organisms (cytarabine), and microorganisms (dactinomycin, bleomycin, and doxorubicin) [57] . MiRNAs are being considered as attractive targets for cancer prevention and therapy due to their oncogenic or tumor suppressor activities [58] ( Table 1).…”

Section: Modulation Of Mirnas By Natural Agentsmentioning

confidence: 99%

Modulation of miRNAs by Natural Agents: Nature’s way of dealing with cancer

Masika

Zhao

Hescheler

et al. 2015

RNA Dis

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Accumulating lines of evidence have revealed that microRNAs (miRNAs) play critical roles in many biological processes, such as carcinogenesis, angiogenesis, programmed cell death, cell proliferation, invasion, migration, and differentiation. They act either as tumor suppressors or oncogenes, and alteration in their expression patterns has been linked to onset, progression and chemoresistance of various cancers. Moreover, miRNAs are also crucial for the regulation of cancer stem cells (CSCs) self-renewal and proliferation as well as control of Epithelial-to-Mesenchymal Transition (EMT) of cancer cells. Therefore, exploitation of miRNAs as targets for cancer prevention and therapy could be a promising approach. Several experimental and epidemiologic studies have shown that dietary intake of natural agents such as baicalin, ginsenoside, curcumin, resveratrol, genistein, epigallocatechin-3-gallate (EGCG), indole-3-carbinol, 3,3΄-diindolylmethane (DIM) including antioxidants among others is inversely associated with the risk for cancer, demonstrating the inhibitory effects of natural agents on carcinogenesis. Additionally, the anticancer agents from natural agents have been found to inhibit the development and progression of cancer through the regulation of various cancer processes such as apoptosis, cell cycle regulation, differentiation, inflammation, angiogenesis, and metastasis. Importantly, natural agents could significantly impact the expression of tumor-suppressor and oncogenic miRNAs, regulate cellular signaling networks, inhibit cancer cell growth and cancer stem cell self-renewal. This is important for the normalization of altered cellular signaling mechanisms in cancer cells. This postulates a much broader use of natural agents in the prevention and/or treatment of various cancers in combination with conventional chemotherapeutics. However, more in vitro mechanistic experiments, in vivo animal studies, and clinical trials are warranted to realize the true value of natural agents in the prevention and/or treatment of cancer. Herein, we provide an overview of natural agents' modulation of miRNA expression as well as highlight the significance of these observations as potential new strategies in cancer therapies. This review will help us to understand how miRNAs are regulated by natural agents and also help in the development of effective and secure natural agents for therapeutic purposes.

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“…3 Cancer is one of the most deadly types of disease and evasion from apoptosis and unstoppable cell proliferation are accepted as its distinctive features. 4 Prostate and lung cancer which are the most common cancer types and are the leading cause of cancer related death worldwide. 4,5 Chemotherapy is frequently used against these cancers but, the major deficiencies of chemotherapeutic agents are systemic toxicity and drug resistance over time.…”

Section: Introductionmentioning

confidence: 99%

“…4 Prostate and lung cancer which are the most common cancer types and are the leading cause of cancer related death worldwide. 4,5 Chemotherapy is frequently used against these cancers but, the major deficiencies of chemotherapeutic agents are systemic toxicity and drug resistance over time. To solve these problems, scientific community enter new search for exploration of efficient chemotherapeutics and natural products are accepted as novel candidate for development new chemotherapeutics due their high anticancer activity and less toxicity in normal cells.…”

Section: Introductionmentioning

confidence: 99%

Morus rubra Extract Induces G1 Cell Cycle Arrest and Apoptosis in Human Lung and Prostate Cancer Cells

Turan¹,

Demir²,

Kilinç³

et al. 2017

IJPER

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Objective: Cancer is one of the most deadly types of disease and evasion from apoptosis and unstoppable cell proliferation are accepted as its distinctive features. Many studies have evaluated the cytotoxic effect of different Morus species but, there is no study about cytotoxic effect of Morus rubra. In this study we aimed to evaluate phenolic composition, antioxidant properties and cytotoxic effect of acidified dimethyl sulfoxide extract of M. rubra (AMRE). Method: Antioxidant properties, phenolic composition and cytotoxic effect of AMRE were determined using spectrophotometric methods, HPLC, and MTT assay, respectively. Then, mechanisms of cytotoxic effect of AMRE on human prostate (PC-3) and lung (A549) cancer cells were examined in regard to cell cycle, apoptosis and mitochondrial membrane potential using flow cytometric methods. Results: Total phenolic content and reducing power values were 11.9 mg gallic acid equivalents and 42.9 mg trolox equivalents per g sample, respectively. Ascorbic and gallic acid were detected in AMRE as major antioxidant compounds. We determined that AMRE increased cell cycle arrest at G 1 phase and exhibited apoptotic features via decreasing mitochondrial membrane potential in both prostate and lung cancer cells. Conclusion: These findings demonstrate that M. rubra extract can affect the behavior of human prostate and lung cancer cells in vitro conditions, and this effect now needs to be investigated in vivo.

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Plant natural products: from traditional compounds to new emerging drugs in cancer therapy

Cited by 122 publications

References 81 publications

Phytochemicals in Cancer Prevention: A Review of the Evidence

Phytochemicals in Cancer Prevention: A Review of the Evidence

Modulation of miRNAs by Natural Agents: Nature’s way of dealing with cancer

Morus rubra Extract Induces G1 Cell Cycle Arrest and Apoptosis in Human Lung and Prostate Cancer Cells

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