A nationwide study of breast disease

Abstract

Records of histopathology from the 3734 Jewish women having breast biopsy and/or operations in all Israeli hospitals during the year from July 1979 to June 1980 were reviewed. Approximately 28.5% of these women were diagnosed as having breast cancer and 71.5% as having benign breast disease: 48.5% had benign proliferative mastopathy (BPM), 16.6% had fibroadenoma (FA) without coexistent BPM, and 6.4% had other benign breast conditions. The age-specific incidence rate was 66 in 100,000 for breast cancer and 165.2 in 100,000 for benign breast disease. Native European or American women and native Israeli women had significantly higher age standardized incidence rates of both breast cancer and BPM, but not of FA, as compared to African/Asian-born women (P < 0.01). Age-related ratios between invasive to precursor breast lesions were similar in all ethnic groups. The data suggest that breast cancer and benign proliferative mastopathy may have a common etiologic component. Cancer 61:2547-2551,1988. AMMARY CARCINOGENESIS seems to be a discon-M tinuous, stepwise process.' While there have been many studies of the association between invasive and noninvasive breast lesions,2-6 their biological relationships have been obscured by the tendency to designate most noninvasive parenchymal lesions, excluding fibro-adenoma, as fibrocystic disease regardless of distinct differences in proliferative and atypical features.' In 1969 Black and Chabon' developed a classification for noninvasive breast lesions in defined segments of the mammary duct system, which specifically recorded the degree of atypical changes. Control type, normotypic ducts, and lobules were graded as 1, while normotypic-hyperplastic changes were graded as 2. Minimal, moderate , and marked degrees of ductal and/or lobular atypia were graded as 3, 4, and 5, respectively. A grading of 5

Histological characteristics of breast lesions in Uyo, Nigeria

“…[ 22 ] BBD is known risk factor for breast cancer, and the relationship is preferentially associated with atypical parenchymal lesions. [ 23 ] In the index study, very few (0.4%) BBD with atypical changes were seen, as such females in our setting do not run the risk of breast cancer from BBD.…”