A National Survey of Endophthalmitis Prophylaxis during Cataract Surgery in Pakistan: A 2020 Perspective

Scantling‐Birch, Yarrow; Naveed, Hasan; Khan, H.; Sheikh, Ijaz; Zia, Rashir

doi:10.36351/pjo.v38i1.1278

Cited by 2 publications

(3 citation statements)

References 17 publications

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“…Unfortunately, in our country, practice protocols to prevent IE are not well defined nationally with wide variations in practice in both public and private sectors. A local survey conducted by the British Pakistani Ophthalmic Society (BPOS) in 2020 highlighted some alarming facts [ 8 ]. According to the survey, only 53.8% of participating surgeons from our country provided some sort of routine antibiotic prophylaxis with the use of PVI on the skin, with the conjunctival sac being the most popular (66.3%).…”

Section: Discussionmentioning

confidence: 99%

“…IC cefuroxime toward the end of the procedure is also a well-known standard for prevention in the international literature [ 7 ]. A local survey done in 2020 assessed nationwide practices in preventing post-op IE, and the results were far from ideal [ 8 ]. Only 66.3% of practitioners were using PVI, while 40.2% were practicing IC cefuroxime despite strong published evidence in favor of both.…”

Section: Introductionmentioning

confidence: 99%

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Role of Prophylactic Oral Antibiotics in the Prevention of Post-cataract Surgery Acute Infective Endophthalmitis

Zafar¹,

Shaheen²,

Afzal³

et al. 2023

Cureus

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To evaluate the role of perioperative oral antibiotics in the prevention of acute infective endophthalmitis (IE) after cataract surgery. MethodsA prospective cohort study of patients older than 18 years of age undergoing uncomplicated phacoemulsification was conducted. Group A was given post-op oral ciprofloxacin for three days, whereas Group B was not. Both groups received 5% povidone-iodine (PVI) preparation for five minutes in the conjunctival cul-de-sac, and intracameral (IC) 0.5% moxifloxacin was administered at the end of the procedure as prophylaxis. The minimum post-op follow-up period was six weeks. ResultsOut of 2161 patients, 859 (39.8%) were included in Group A, and 1302 (60.2%) were included in Group B. No significant difference in anterior chamber (AC) reaction was found on day 1 (p = 0.67), day 14 (p = 0.03), or day 45 (p = 0.1). One patient developed acute post-op IE (0.04%) and two patients developed toxic anterior segment syndrome (TASS) from Group A. The non-oral antibiotic group had no serious complications. ConclusionPerioperative oral antibiotic use in routine clinical practice is not recommended for the prevention of acute post-op IE. Pre-op conjunctival PVI 5% for five minutes and IC moxifloxacin at the end of surgery were proven to be effective prophylactic measures in our study.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Role of Prophylactic Oral Antibiotics in the Prevention of Post-cataract Surgery Acute Infective Endophthalmitis

Zafar¹,

Shaheen²,

Afzal³

et al. 2023

Cureus

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“…2 Childhood Congenital cataracts represent around 22.3% of congenital cataracts worldwide, while the incidence of pediatric cataracts among the children attending eye outpatient clinics in Pakistan is 11.69%. 3,4 Cataracts are the major cause of bilateral blindness (VA<3/60) in 46.5% of all instances. Shaikh S.P.…”

Section: Introductionmentioning

confidence: 99%

A Novel CRYBB2 Silent Variant in Autosomal Dominant Congenital Cataracts (ADCC) in Pakistani families

et al. 2023

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Objective: Congenital Cataract is a type of ophthalmic genetic disorder that appears at birth or in early childhood. Among 30 genes, CRYBB2 is one of the most common and a water-soluble protein of lens’s that code for the βB2-crystallin. This study aimed to investigate the novel silent mutation in CRYBB2 of exon six in the Pakistani families of Autosomal Dominant Congenital Cataracts (ADCC). Methods: It is a family-based study that presents three to five-generations of two Pakistani families. Data and blood samples from the families were collected from January to August 2019 from LRBT (Layton Rahmatullah Benevolent Trust) Hospital, Mansehra, Pakistan. We only included patients >15 years old. Before enrollment in the current study, each patient obtained a thorough optical examination. Samples were moved to the molecular lab using the collection and storage method. The phenol-chloroform technique was used to extract the DNA. The technique of Sanger sequencing was used to find any potential mutation in some of the selected families. Statistical and bioinformatics analysis were carried out. Results: By using bioinformatics tools, the novel silent mutation was identified. Heterozygous silent mutation of CRYBB2 of exon 6 (c. 495G>A) was detected by the alignment of sequences. Computational prediction program did not predict the silent mutation. Conclusion: This study investigated a novel important sequence variant in the beta-crystalline protein that causes autosomal dominant congenital cataract (ADCC) in Pakistani families. Thus, our study enlarges the CRYBB2 mutation spectrum and associated phenotypes to help clinical diagnosis of human genetic diseases. doi: https://doi.org/10.12669/pjms.39.5.7061 How to cite this: Hussain M, Muhammad K, Khan M, Aziz Ud Din. A Novel CRYBB2 Silent Variant in Autosomal Dominant Congenital Cataracts (ADCC) in Pakistani families. Pak J Med Sci. 2023;39(5):---------. doi: https://doi.org/10.12669/pjms.39.5.7061 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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A National Survey of Endophthalmitis Prophylaxis during Cataract Surgery in Pakistan: A 2020 Perspective

Cited by 2 publications

References 17 publications

Role of Prophylactic Oral Antibiotics in the Prevention of Post-cataract Surgery Acute Infective Endophthalmitis

Role of Prophylactic Oral Antibiotics in the Prevention of Post-cataract Surgery Acute Infective Endophthalmitis

A Novel CRYBB2 Silent Variant in Autosomal Dominant Congenital Cataracts (ADCC) in Pakistani families

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