A national reconnaissance of pharmaceuticals and other organic wastewater contaminants in the United States — I) Groundwater

Barnes, Kimberlee K.; Kolpin, Dana W.; Furlong, Edward T.; Zaugg, Steven D.; Meyer, Michael T.; Barber, Larry B.

doi:10.1016/j.scitotenv.2008.04.028

Cited by 634 publications

(280 citation statements)

References 42 publications

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“…The observed increases in urinary BPA levels (75) were smaller compared with what was observed with canned food intake (46) . BPA has also been found in products made from recycled paper (76) , dust particles (77)(78)(79) , dental fillings (80) and soil, tap and surface water (81)(82)(83)(84)(85)(86) , but current data indicate these sources of exposure contribute only minimally to overall exposure (59,73,87,88) .…”

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confidence: 95%

Estimating bisphenol A exposure levels using a questionnaire targeting known sources of exposure

Nomura

Harnack

Robien

2015

Public Health Nutr.

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Objective: To develop a BPA Exposure Assessment Module (BEAM) for use in large observational studies and to evaluate the ability of the BEAM to estimate bisphenol A (BPA) exposure levels. Design: The BEAM was designed by modifying an FFQ with questions targeting known sources of BPA exposure. Frequency of intake of known dietary sources of BPA was assessed using the BEAM and three 24 h food records as a reference diet measurement tool. Urinary BPA (uBPA) levels were measured as the criterion tool in a pooled urine sample (nine spot samples per participant). Spearman correlations, linear regression and weighted kappa analysis were used to evaluate the ability of the BEAM and food records to estimate BPA exposure levels. Setting: Minneapolis/Saint Paul, MN, USA. Subjects: Sixty-eight healthy adult (20-59 years) volunteers. Results: Dietary BPA intake assessed by the BEAM was not associated with uBPA levels and was unable to predict participants' rank by uBPA levels. BEAM models with all a priori predictors explained 25 % of the variability in uBPA levels. Canned food intake assessed by food records was associated with uBPA levels, but was unable to rank participants by uBPA levels. Multivariable-adjusted food record models with a priori predictors explained 41 % of the variability in uBPA levels. Conclusions: Known dietary sources of BPA exposure explained less than half the variability in uBPA levels, regardless of diet assessment method. Findings suggest that a questionnaire approach may be insufficient for ranking BPA exposure level and additional important sources of BPA exposure likely exist.Bisphenol A (BPA), used in the manufacture of polycarbonate plastics and epoxy resins, is one of the highest-volume chemicals produced worldwide (1,2) and production is predicted to reach more than 4·09 Mt (9 billion lb) by 2020 (3) . Biomonitoring data indicate widespread, chronic low-level exposure to BPA (2,(4)(5)(6) . Animal and in vitro data indicate exposure adversely affects health, but limited and conflicting human epidemiological data is often cited as a barrier for risk assessment by regulatory agencies (7)(8)(9) . While recent epidemiological data suggest that BPA may be associated with alterations in sex and thyroid hormone levels (10)(11)(12)(13)(14)(15)(16)(17)(18) , infertility and polycystic ovary syndrome (19)(20)(21) , obesity (18,(22)(23)(24)(25)(26)(27)(28)(29) , pre-diabetes/type 2 diabetes (23,(30)(31)(32) and CVD (23,31,(33)(34)(35) , most are crosssectional analyses with important limitations, such as lack of long-term exposure data which are more relevant for chronic disease risk (36) . Diet has been considered the primary source of BPA exposure (37)(38)(39)(40)(41)(42)(43) and previous studies support diet as the major route of human BPA exposure (44)(45)(46)(47)(48)(49)(50) . The use of polycarbonate plastics in the production of food and beverage storage containers has been largely phased out in the USA. However, BPA is still used in epoxy resin linings of metal cans and lids (1,2,6,51...

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confidence: 95%

Estimating bisphenol A exposure levels using a questionnaire targeting known sources of exposure

Nomura

Harnack

Robien

2015

Public Health Nutr.

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“…Previous research has revealed the presence of various contaminants in groundwater. Several antibiotic compounds (e.g., sulfamethoxazole, lincomycin, and erythromycin) have been detected in groundwater in Europe and North America, with maximum concentrations in the range of 5.7-103 ng L −1 (Barnes et al, 2008;Garcia-Galan et al, 2010). Moreover, a variety of industrial chemicals (e.g., detergents, fire retardants, and plasticizers), PPCPs (e.g., anti-inflammatories, β-blockers, drugs of abuse, antiseptics, preservatives, and sweeteners) and their metabolites have been observed in groundwater Grujic et al, 2009;Hohenblum et al, 2004;Houtz et al, 2013;Jurado et al, 2012a,b;Kahle et al, 2009;Kuroda et al, 2012;Lopez-Serna et al, 2013;Loos et al, 2010;Osenbruck et al, 2007;Schaider et al, 2014;Teijon et al, 2010;Vulliet and Cren-Olive, 2011;Wolf et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…A variety of chemicals, including high concentrations of dissolved organic/inorganic carbon, ammonium, methane, and heavy metals, have been detected in landfill leachate (Befenati et al, 2003;Li et al, 2014;Peng et al, 2014;Roy et al, 2014;Yamamoto et al, 2001). In addition, research has also revealed persistence of various chemicals, such as plasticizers and PPCPs, in the groundwater down gradient of landfills (Barnes et al, 2008;Buszka et al, 2009). Holm et al (1995) detected sulfonamides in the groundwater down gradient of a landfill site in Denmark at concentrations up to 10 4 -10 6 ng/L.…”

Section: Introductionmentioning

confidence: 99%

Occurrence and ecological potential of pharmaceuticals and personal care products in groundwater and reservoirs in the vicinity of municipal landfills in China

Peng

Wang

et al. 2014

Science of The Total Environment

240

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“…Due to the improper and untreated disposal of sulfonamides in feed, sulfonamides and their metabolites are widespread in the environments and have frequently resulted in the contamination of water or soil (Halling et al 1998;Fent et al 2006;Ye et al 2007;Barnes et al 2008;Focazio et al 2008). Sulfonamides are now widely recognized as environmental contaminants (Sukul and Spiteller 2006).…”

Section: Introductionmentioning

confidence: 99%

“…Biodegradation of sulfonamides present in wastewater treatment plants (WWTPs), surface water, manure and soils was summarized by Jesús García-Galán et al (2008). Sulfonamides appeares to resist natural biodegradation rather strongly, which is reflected in the high frequency of their detection in streams and rivers (Kim et al 2007;Vieno et al 2007;Barnes et al 2008;Focazio et al 2008). Kuhn and Suflita (1989) reported the anaerobic biodegradation of para-toluenesulfonamide and benzenesulfonamide in aquifer slurries from a sulphate-reducing and methanogenic site.…”

Section: Introductionmentioning

confidence: 99%

Isolation and characterization of sulfonamide-degrading bacteria Escherichia sp. HS21 and Acinetobacter sp. HS51

Zhang

Wen

Niu

et al. 2011

World J Microbiol Biotechnol

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With the intensive application of sulfonamides in aquaculture and animal husbandry and the increase of sulfonamides discharged into the environments, there is an increasing need to find a way to remediate sulfonamidecontaminated environments. Two bacterial strains capable of degrading sulfonamides, HS21 and HS51, were isolated from marine environments. HS21 and HS51 were identified as members of Escherichia sp. and Acinetobacter sp., respectively, based on 16S rRNA gene sequencing. Degradation of each sulfonamide by Escherichia sp. HS21 and Acinetobacter sp. HS51 was characterized using capillary electrophoresis. About 66 or 72% of sulfapyridine and 45 or 67% of sulfathiazole contained in the media was degraded by Escherichia sp. HS21 or Acinetobacter sp. HS51, respectively, after incubation for 2 days. The supernatant from culture of Escherichia sp. HS21 or Acinetobacter sp. HS51 grown in sulfapyridine or sulfathiazole contained media had much attenuated cytotoxicity against HeLa cells. These results suggest that Escherichia sp. HS21 and Acinetobacter sp. HS51 are new bacterial resources for biodegrading sulfonamides and indicate the potential of isolated strains for the bioremediation of sulfonamide-polluted environments.

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A national reconnaissance of pharmaceuticals and other organic wastewater contaminants in the United States — I) Groundwater

Cited by 634 publications

References 42 publications

Estimating bisphenol A exposure levels using a questionnaire targeting known sources of exposure

Estimating bisphenol A exposure levels using a questionnaire targeting known sources of exposure

Occurrence and ecological potential of pharmaceuticals and personal care products in groundwater and reservoirs in the vicinity of municipal landfills in China

Isolation and characterization of sulfonamide-degrading bacteria Escherichia sp. HS21 and Acinetobacter sp. HS51

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