A narrative review of hydrogen oncology: from real world survey to real world evidence

Abstract

The use of hydrogen for cancer control has made great progress in cytology and animal experiments. With the increasing number of hydrogen products on the market, larger numbers of advanced cancer patients have participated in clinical trials or received treatment at home after purchase. Our study reported a real-world survey from 82 patients with good cancer control using hydrogen products, including real world evidence from patients who received ineffective traditional treatment, patients who received traditional treatment that failed, or patients who refused traditional treatment. Two typical cases were reported herein. Subsequently, we included studies on the mechanism of hydrogen oncology. The mechanism of cancer control using hydrogen includes the inhibition of tumor cells and the activation of exhausted lymphocytes. Large-scale real world evidence has shown clinical value, and yet remains to be further developed and researched.

Potential role of hydrogen sulfide in central nervous system tumors: a narrative review

“… 27 30 There is increasing evidence that IDH1, closely related to the carcinogenesis mediated by HIF-1α, is the most common mutated gene in GBM. 31 32 33 The mutated IDH1 increases its level by protecting HIF-1α from degradation. In the midst of IDH1 mutant gliomas, the transcriptional activity of HIF-1α increases, intensifying the growth of gliomas.…”

Inhalation of 4% and 67% hydrogen ameliorates oxidative stress, inflammation, apoptosis, and necroptosis in a rat model of glycerol-induced acute kidney injury

“…Numerous studies have reported the therapeutic effects of H 2 on oxidative stress and inflammation-related diseases such as ischemia and reperfusion injuries, 17 18 19 atherosclerosis, 20 21 22 metabolic diseases, 23 24 25 neurodegenerative disorders, 26 27 and cancer. 28 29 30 31 These effects of H 2 are usually attributed to its anti-oxidative, anti-inflammatory, and anti-apoptotic capabilities. Recently, H 2 supplements have been tried in the treatment of COVID-19.…”