A narrative review of changes in microvascular permeability after burn

Chi, Yunfei; Liu, Xiangyu; Chai, Jiake

doi:10.21037/atm-21-1267

Cited by 16 publications

(15 citation statements)

References 164 publications

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“…Increased microvascular permeability is one of the main characteristics of burn injury and it has been clearly observed in the peripheral vessels [ 36 ]. Several studies have also investigated the cerebral vascular response to systemic thermal injury.…”

Section: Reviewmentioning

confidence: 99%

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Pathological changes in the brain after peripheral burns

Chen

Zhang

et al. 2023

Burns &Amp; Trauma

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Brain injuries are common complications in patients with thermal burns and are associated with unpleasant outcomes. In clinical settings, it was once believed that brain injuries were not major pathological processes after burn, at least in part due to the unavailability of specific clinical manifestations. Burn-related brain injuries have been studied for more than a century, but the underlying pathophysiology has not been completely clarified. This article reviews the pathological changes in the brain following peripheral burns at the anatomical, histological, cytological, molecular and cognitive levels. Therapeutic indications based on brain injury as well as future directions for research have been summarized and proposed.

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Section: Reviewmentioning

confidence: 99%

“…Neutrophils are activated after severe burn injuries [ 36 ]. Damaged BBB and increased microvascular permeability allow systemic neutrophils to infiltrate freely into the perivascular space.…”

Section: Reviewmentioning

confidence: 99%

Pathological changes in the brain after peripheral burns

Chen

Zhang

et al. 2023

Burns &Amp; Trauma

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“…More than 2/3 of the contributors in our study believed that all burn injuries needn't be treated at the hospital as some of the burns could be managed at home or the place of the incident. A burn can cause a large systemic response in the body and there is an excessive release of systemic-inflammatory-mediators and cytokines that leads to greater capillary permeability and wide-scaleextravasation of liquid & proteins (Chi et al, 2021). In order to maintain homeostasis, the skin performs a different function, including controlling body temperature and fluid balance.…”

Section: Discussionmentioning

confidence: 99%

Knowledge and practices related to burn first aid among Saudi population

Mahfouz¹,

Alghoraibi²,

Alshareef³

et al. 2022

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Background: Burn is a breakdown of skin continuity which is considered a major problem worldwide. The best approach to manage burns is to start with first aid. Numerous studies conducted in several regions revealed a widespread lack of understanding about first aid for burns. To assess the general knowledge and practices related to burn first aid treatment among the population in Saudi Arabia. Methods: We conducted a cross-sectional study with a representative random sample of 449 Saudi residents in the Kingdom of Saudi Arabia using a self-administered questionnaire that was distributed through social media sites. For data analysis, we used Statistical Package of Social Science Software (SPSS) version 24. Results: Out of 449 participants that met our inclusion criteria, most study participants were females, 371 (82.6%) and 203 (45.2%) aged between 18-29 years old. Also 239 (53.2%) didn't believe that cold water could be poured if hot oil spills on the hands and only 95 (21.1%) agreed that all burn injuries must be treated in the hospital. Conclusion:The results of the research suggest that the general community of Saudi Arabia has a significant lack of awareness about burn wound treatment. This survey also showed a number of gaps in awareness and practices that will need to be corrected in the near future. Various media platforms should be used to create public programs aimed at increasing community knowledge.

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“…Patients who experience burns have increased vascular permeability and more exudate resulting in reduced blood volume ( 95 ), often resorting to blood transfusion to combat hypovolemic shock. In addition to the above, intraoperative blood transfusion is usually an option for burn patients due to the high intraoperative bleeding and exudation associated with their surgical approach.…”

Section: Methodsmentioning

confidence: 99%

Research progress on risk factors of delirium in burn patients: A narrative review

et al. 2022

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Delirium, an acute brain dysfunction, is a common and serious complication in burn patients. The occurrence of delirium increases the difficulty of patient treatment, is associated with various adverse outcomes, and increases the burden on the patient’s family. Many scholars have studied the factors that cause delirium, but the causes, pathogenesis, and treatment of delirium in burn patients have not been fully revealed. There is no effective pharmacological treatment for delirium, but active preventive measures can effectively reduce the incidence of delirium in burn patients. Therefore, it is necessary to study the relevant factors affecting the occurrence of delirium in burn patients. This study was conducted on December 20, 2021 by searching the PubMed database for a narrative review of published studies. The search strategy included keywords related to “burns,” “delirium,” and “risk factors.” We reviewed the characteristics of delirium occurrence in burn patients and various delirium assessment tools, and summarized the risk factors for the development of delirium in burn patients in terms of personal, clinical, and environmental factors, and we found that although many risk factors act on the development of delirium in burn patients, some of them, such as clinical and environmental factors, are modifiable, suggesting that we can estimate the exposure of burn patients to risk factors by assessing their likelihood of delirium occurring and to make targeted interventions that provide a theoretical basis for the prevention and treatment of burn delirium.

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A narrative review of changes in microvascular permeability after burn

Cited by 16 publications

References 164 publications

Pathological changes in the brain after peripheral burns

Pathological changes in the brain after peripheral burns

Knowledge and practices related to burn first aid among Saudi population

Research progress on risk factors of delirium in burn patients: A narrative review

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