A nanozyme-linked immunosorbent assay based on metal–organic frameworks (MOFs) for sensitive detection of aflatoxin B1

Xu, Zhou; Long, Lingli; Chen, Yanqiu; Chen, Mao-Long; Cheng, Yunhui

doi:10.1016/j.foodchem.2020.128039

Cited by 98 publications

(36 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Developed ELISA protocols based on nanomaterials as enzyme substitute can be also considered for practical applications due to greater stability than conventional ELISA. In this regard, the nanozyme-linked immunosorbent assay based on MOFs (Table 2) for AFB1 detection is a good example [63]. The developed method showed high sensitivity and selectivity, high accuracy and excellent stability without false positive and false negative results.…”

Section: Interesting Examples From Literature With Great Potential For Industrial Applicationsmentioning

confidence: 99%

“…Different kinds of nanomaterials-including noble metal nanoparticles (e.g., AuNP and AgNPs), graphene oxide, magnetic iron oxide, etc.-have been used in sensing methods. Xu et al proposed a nanozyme-linked immunosorbent assay using metal-organic frameworks (MOFs) for AFB1 detection [63]. MOF with peroxidase-like activity was replaced with HRP for antibody labeling and catalyzing TMB to generate colorimetric signal.…”

Section: Enzyme-linked Immunosorbent Assay (Elisa)mentioning

confidence: 99%

See 1 more Smart Citation

Advances in Colorimetric Strategies for Mycotoxins Detection: Toward Rapid Industrial Monitoring

Majdinasab

Aissa

Marty

2020

Toxins

View full text Add to dashboard Cite

Mycotoxins contamination is a global public health concern. Therefore, highly sensitive and selective techniques are needed for their on-site monitoring. Several approaches are conceivable for mycotoxins analysis, among which colorimetric methods are the most attractive for commercialization purposes thanks to their visual read-out, easy operation, cost-effectiveness, and rapid response. This review covers the latest achievements in the last five years for the development of colorimetric methods specific to mycotoxins analysis, with a particular emphasis on their potential for large-scale applications in food industries. Gathering all types of (bio)receptors, main colorimetric methods are critically discussed, including enzyme-linked assays, lateral flow-assays, microfluidic devices, and homogenous in-solution strategies. This special focus on colorimetry as a versatile transduction method for mycotoxins analysis is comprehensively reviewed for the first time.

show abstract

Section: Interesting Examples From Literature With Great Potential For Industrial Applicationsmentioning

confidence: 99%

Section: Enzyme-linked Immunosorbent Assay (Elisa)mentioning

confidence: 99%

Advances in Colorimetric Strategies for Mycotoxins Detection: Toward Rapid Industrial Monitoring

Majdinasab

Aissa

Marty

2020

Toxins

View full text Add to dashboard Cite

show abstract

“…To overcome these limitations, numerous nanozymes have been developed, considered direct substitutes for HRP [150]. For instance, Xu and Cheng [151], to avoid the occurrence of false positives and false negatives caused by conventional ELISA, have recently developed a nanozyme-linked immunosorbent assay based on metal-organic frameworks (MOFs) for sensitive detection of aflatoxin B1. As a result, the limit of detection (LOD) of the MOFLISA method was 0.009 ng/mL with a linear working range from 0.01 to 20 ng/mL, thus having a 20-fold improved LOD value compared with the conventional test.…”

Section: Metal Nanozymes As Cellular Probes For Biosensingmentioning

confidence: 99%

Metal Nanozymes: New Horizons in Cellular Homeostasis Regulation

2021

View full text Add to dashboard Cite

Nanomaterials with enzyme-like activity (nanozymes) have found applications in various fields of medicine, industry, and environmental protection. This review discusses the use of nanozymes in the regulation of cellular homeostasis. We also review the latest biomedical applications of nanozymes related to their use in cellular redox status modification and detection. We present how nanozymes enable biomedical advances and demonstrate basic design strategies to improve diagnostic and therapeutic efficacy in various diseases. Finally, we discuss the current challenges and future directions for developing nanozymes for applications in the regulation of the redox-dependent cellular processes and detection in the cellular redox state changes.

show abstract

“…Among them, metal-organic frameworks (MOFs) have been used as heterogeneous catalysts. MOFs are a new type of catalyst with high catalytic activities [17], which have a porous structure, large size, different ligands for functionalization, and widely applications in many areas [18][19][20]. Among the MOFs catalysts, the Fe-based MOF as a Fenton catalyst has its advantages [17], this is because Fe has a wide source and is non-toxic [21].…”

Section: Introductionmentioning

confidence: 99%

NH2-Fe-MILs for effective adsorption and Fenton-like degradation of imidacloprid: Removal performance and mechanism investigation

Chen¹,

Lu²,

Long³

et al. 2021

Environmental Engineering Research

Self Cite

View full text Add to dashboard Cite

This investigation enables amino-functionalized metal-organic frameworks (MOFs) materials for the removal of imidacloprid (IMC). Two Fe-based MOF materials of NH 2-MIL-88B(Fe) and NH 2-MIL-101(Fe) both exhibited high adsorption capacity and Fenton-like degradation ability for IMC which were utilized to remove IMC from aqueous solution. Although the adsorption capacity of NH 2-MIL-101(Fe) was higher than that of NH 2-MIL-88(Fe), the degradation abilities of both MOF materials were similar. The removal efficiencies were evaluated through several basic studies, including concentrations of catalyst (0.12-0.3 g/L) and IMC (20-100 mg/L), pH of solution (3-11), and amounts of 30% H 2 O 2 (0-2.0 μL/mL). By optimizing the above factors, the total removal ratio of IMC by NH 2-MIL-88B(Fe) was as high as 93%, whereas the removal ratio of NH 2-MIL-101(Fe) was 97%. Moreover, these MOF materials were proven to be stable and recyclable. The free radical quenching experiment and density functional theory calculation were applied to research the removal mechanism, and the hydroxyl radicals (•OH) was found to be the key active intermediate. The high catalytic efficiency can be attributed to the synergy of the Fe 3+ /Fe 2+ redox cycle.

show abstract

A nanozyme-linked immunosorbent assay based on metal–organic frameworks (MOFs) for sensitive detection of aflatoxin B1

Cited by 98 publications

References 31 publications

Advances in Colorimetric Strategies for Mycotoxins Detection: Toward Rapid Industrial Monitoring

Advances in Colorimetric Strategies for Mycotoxins Detection: Toward Rapid Industrial Monitoring

Metal Nanozymes: New Horizons in Cellular Homeostasis Regulation

NH2-Fe-MILs for effective adsorption and Fenton-like degradation of imidacloprid: Removal performance and mechanism investigation

Contact Info

Product

Resources

About