A nanoscale photothermal agent based on a metal-organic coordination polymer as a drug-loading framework for effective combination therapy

Li, Jing; Zhang, Cuiting; Gong, Siman; Li, Xincong; Yu, Minye; Qian, Chenggen; Qiao, Hongzhi; Sun, Minjie

doi:10.1016/j.actbio.2019.06.014

Cited by 49 publications

(24 citation statements)

References 45 publications

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“…A significant absorption peak at 570 nm witnessed the successful formation of coordination bonds in TA/Fe chelates, which was in accordance with the previous reports. [54] Additionally, a noticeable difference between the color of QCS/TA hydrogel (orange) and QCS/TA/Fe hydrogel (black) from Figure S1b also indicated the successful binding of TA and Fe(III).…”

Section: Preparation Gelation Time Rheological Performance Morphology...mentioning

confidence: 92%

One‐Step Synthesis of Multifunctional Chitosan Hydrogel for Full‐Thickness Wound Closure and Healing

Guo

Yao

Zhang

et al. 2021

Adv Healthcare Materials

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Multifunctional hydrogel as a sealant or wound dressing with high adhesiveness and excellent antibacterial activity is highly desirable in clinical applications. In this contribution, one-step synthetic hydrogel based on quaternized chitosan (QCS), tannic acid (TA), and ferric iron (Fe(III)) is developed for skin incision closure and Staphylococcus aureus (S. aureus)-infected wound healing. In this hydrogel system, the ionic bonds and hydrogen bonds between QCS and TA form the main backbone of hydrogel, the metal coordination bonds between TA and Fe(III) (catechol-Fe) endow hydrogel with excellent adhesiveness and (near-infrared light) NIR-responsive photothermal property, and these multiple dynamic physical crosslinks enable QCS/TA/Fe hydrogel with flexible self-healing ability and injectability. Moreover, QCS/TA/Fe hydrogel possesses superior antioxidant, anti-inflammatory, hemostasis, and biocompatibility. Also, it is safe for vital organs. The data from the mouse skin incision model and infected full-thickness skin wound model presented the high wound closure effectiveness and acceleration of the wound healing process by this multifunctional hydrogel, highlighting its great potential in wound management.

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Section: Preparation Gelation Time Rheological Performance Morphology...mentioning

confidence: 92%

One‐Step Synthesis of Multifunctional Chitosan Hydrogel for Full‐Thickness Wound Closure and Healing

Guo

Yao

Zhang

et al. 2021

Adv Healthcare Materials

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“…Currently, various types of inorganic and organic photothermal agents have been exploited for their ability to perform PTT on tumors. Inorganic photothermal agents mainly include gold nanomaterials, like gold nanoparticles (GNPs), gold nanorods (GNRs) and gold nanostars (AuNSs) 18 , 19 ; carbon based materials, such as single-walled carbon nanotubes (SWCNTs), graphene and carbon dots (CD) 20 , 21 ; sulfide metallic nanoparticles, for example, CuS and MnS 2 22 ; black phosphorus and etc. 23 .…”

Section: Introductionmentioning

confidence: 99%

“…Their photothermal property can be adjusted by varying their size, shape or doping with other elements 24 . However, the slow degradation rate in vivo might cause potential toxicity 18 . While the organic photothermal agents typically include small molecular dyes, such as indocyanine green (ICG) and IR780; polydopamine (pD), polyaniline (PANI) and polypyrrole nanoparticles 25 .…”

Section: Introductionmentioning

confidence: 99%

Recent strategies for nano-based PTT combined with immunotherapy: from a biomaterial point of view

et al. 2021

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Cancer has been a great threat to humans for decades. Due to the limitations of monotherapy, combinational therapies such as photothermal therapy (PTT) and immunotherapy have gained increasing attention with expectation to overcome the shortfalls of each other and obtain satisfactory therapeutic outcomes. PTT can inhibit primary tumors by thermal ablation but usually fails to achieve complete eradication and cannot prevent metastasis and recurrence. Meanwhile, the efficacy of immunotherapy is usually attenuated by the weak immunogenicity of tumor and the immunosuppressive tumor microenvironment (ITM). Therefore, many recent studies have attempted to synergize PTT with immunotherapy in order to enhance the therapeutic efficacy. In this review, we aim to summarize the cutting-edge strategies in combining nano-based PTT with immunotherapy for cancer treatment. Herein, the combination strategies were mainly classified into four categories, including 1) nano-based PTT combined with antigens to induce host immune responses; 2) nano-based PTT in combination with immune adjuvants acting as in situ vaccines; 3) nano-based PTT synergized with immune checkpoint blockade or other regulators to relieve the ITM; 4) nano-based PTT combined with CAR-T therapy or cytokine therapy for tumor treatment. The characteristics of various photothermal agents and nanoplatforms as well as the immunological mechanisms for the synergism were also introduced in detail. Finally, we discussed the existing challenges and future prospects in combined PTT and immunotherapy.

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“…24 Thus, the combination of ZIF-8 with organic materials is more preferable for in vivo theranostics. [25][26][27] Specially, polydopamine (PDA) has been widely utilized as a photothermal agent to construct multifunctional nanoplatforms due to its excellent biocompatibility, biodegradability and photothermal conversion ability. 28 Moreover, the surface modification of PDA also offers more opportunities for further functionalization and even regulation of cell-interfaces behavior.…”

Section: Introductionmentioning

confidence: 99%

<p>Surface Engineering of Metal–Organic Framework as pH-/NIR-Responsive Nanocarrier for Imaging-Guided Chemo-Photothermal Therapy</p>

Guo

Xia

Feng

et al. 2020

IJN

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Background: Metal-organic frameworks (MOFs) have attracted intensive research interest in the biomedical field because of their unique properties. However, in order to realize the high loading capacity and therapeutic efficacy, it is still urgent to develop a multifunctional MOFs-based nanoplatform. Materials and Methods: Herein, a pH/near-infrared (NIR) dual-responsive drug delivery system based on zeolitic imidazolate framework-8 (ZIF-8) is constructed for synergistic chemo-photothermal therapy and dual-modal magnetic resonance (MR)/photoacoustic (PA) imaging. The doxorubicin hydrochloride (DOX) is embedded into ZIF-8 through one-pot method, and the resultant ZIF-8/DOX is then successively modified with polydopamine, Mn ions and poly(ethylene glycol). The obtained ZIF-8/DMPP is systematically characterized, and both its in vitro and in vivo biological effects are evaluated in detail. Results: The ZIF-8/DMPP possesses a high drug-loading content of 18.9% and displays appropriate size and morphology. The pH-dependent degradation and drug release behavior of prepared ZIF-8/DMPP are confirmed. Importantly, the results demonstrate that the photothermal effect of ZIF-8/DMPP under NIR laser irradiation can significantly accelerate its drug releasing rate, further improving the intracellular drug concentrations. Thereafter, the augmented chemotherapeutic efficiency by photothermal effect against cancer cells is verified both in vitro and in vivo. Besides, the favorable MR and PA imaging capacity of ZIF-8/ DMPP is also evidenced on the tumor model. Conclusion: Taken together, the surface engineering of ZIF-8-based nanocarrier in this work offers a promising strategy for the multifunctional MOFs-based drug delivery system.

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A nanoscale photothermal agent based on a metal-organic coordination polymer as a drug-loading framework for effective combination therapy

Cited by 49 publications

References 45 publications

One‐Step Synthesis of Multifunctional Chitosan Hydrogel for Full‐Thickness Wound Closure and Healing

One‐Step Synthesis of Multifunctional Chitosan Hydrogel for Full‐Thickness Wound Closure and Healing

Recent strategies for nano-based PTT combined with immunotherapy: from a biomaterial point of view

<p>Surface Engineering of Metal–Organic Framework as pH-/NIR-Responsive Nanocarrier for Imaging-Guided Chemo-Photothermal Therapy</p>

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