A Nanoscale Metal–Organic Framework to Mediate Photodynamic Therapy and Deliver CpG Oligodeoxynucleotides to Enhance Antigen Presentation and Cancer Immunotherapy

Ni, Kaiyuan; Luo, Taokun; Lan, Guangxu; Culbert, August; Song, Yang; Wu, Tong; Jiang, Xiaoming; Lin, Wenbin

doi:10.1002/anie.201911429

Cited by 151 publications

(69 citation statements)

References 34 publications

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“…Through solvothermal reactions between benzoporphyrin and WCl 6 , benzoporphyrin was incorporated into a W-based nMOF [72]. Anionic CpG as an adjuvant was adsorbed on the surface of the cationic nMOF.…”

Section: In Situ Cancer Vaccination With Nmofs For Combinatorial Therapymentioning

confidence: 99%

Nanomedicines based on nanoscale metal-organic frameworks for cancer immunotherapy

Zhong

Sun

2020

Acta Pharmacol Sin

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Cancer immunotherapy, with an aim to enhance host immune responses, has been recognized as a promising therapeutic treatment for cancer. A diversity of immunomodulatory agents, including tumor-associated antigens, adjuvants, cytokines and immunomodulators, has been explored for their ability to induce a cascading adaptive immune response. Nanoscale metal-organic frameworks (nMOFs), a class of crystalline-shaped nanomaterials formed by the self-assembly of organic ligands and metal nodes, are attractive for cancer immunotherapy because they feature tunable pore size, high surface area and loading capacity, and intrinsic biodegradability. In this review we summarize recent progress in the development of nMOFs for cancer immunotherapy, including cancer vaccine delivery and combination of in situ vaccination with immunomodulators to reverse immune suppression. Current challenges and future perspectives for rational design of nMOF-based cancer immunotherapy are also discussed.

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Section: In Situ Cancer Vaccination With Nmofs For Combinatorial Therapymentioning

confidence: 99%

Nanomedicines based on nanoscale metal-organic frameworks for cancer immunotherapy

Zhong

Sun

2020

Acta Pharmacol Sin

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“…(4) Relatively labile coordination bond connections make nMOFs intrinsically biodegradable in physiological environments for biocompatibility. As a result, nMOFs have been successfully applied to the delivery of chemotherapeutic agents, [200][201][202] imaging contrast agents, 172, 203 photosensitizers, [204][205][206][207][208][209][210][211][212][213] proteins [214][215] and gene therapy drugs. [216][217][218] In this dissertation, I report the progress on the design of nMOFs as nanosensitizers to enhance RT, 219 mediate radiotherapy-radiodynamic therapy (RT-RDT), [220][221] and enable PDT and CDT 222 with the advantages of high payload, crystalline order, and porous structures for ROS generation.…”

Section: Nanoscale Metal-organic Framework For Cancer Immunotherapymentioning

confidence: 99%

Nanoscale Metal–Organic Frameworks for Cancer Immunotherapy

et al. 2020

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Conspectus Cancer immunotherapy, particularly checkpoint blockade immunotherapy (CBI), has revolutionized the treatment of some cancers by reactivating the antitumor immunity of hosts with durable response and manageable toxicity. However, many cancer patients with low tumor antigen exposure and immunosuppressive tumor microenvironments do not respond to CBI. A variety of methods have been investigated to reverse immunosuppressive tumor microenvironments and turn “cold” tumors “hot” with the goal of extending the therapeutic benefits of CBI to a broader population of cancer patients. Immunostimulatory adjuvant treatments, such as cancer vaccines, photodynamic therapy (PDT), radiotherapy (RT), radiotherapy–radiodynamic therapy (RT-RDT), and chemodynamic therapy (CDT), promote antigen presentation and T cell priming and, when used in combination with CBI, reactivate and sustain systemic antitumor immunity. Cancer vaccines directly provide tumor antigens, while immunoadjuvant therapies such as PDT, RT, RT-RDT, and CDT kill cancer cells in an immunogenic fashion to release tumor antigens in situ. Direct administration of tumor antigens or indirect intratumoral immunoadjuvant therapies as in situ cancer vaccines initiate the immuno-oncology cycle for antitumor immune response. With the rapid growth of cancer nanotechnology in the past two decades, a large number of nanoparticle platforms have been studied, and some nanomedicines have been translated into clinical trials. Nanomedicine provides a promising strategy to enhance the efficacy of immunoadjuvant therapies to potentiate cancer immunotherapy. Among these nanoparticle platforms, nanoscale metal–organic frameworks (nMOFs) have emerged as a unique class of porous hybrid nanomaterials with metal cluster secondary building units and organic linkers. With molecular modularity, structural tunability, intrinsic porosity, tunable stability, and biocompatibility, nMOFs are ideally suited for biomedical applications, particularly cancer treatments. In this Account, we present recent breakthroughs in the design of nMOFs as nanocarriers for cancer vaccine delivery and as nanosensitizers for PDT, CDT, RT, and RT-RDT. The versatility of nMOFs allows them to be fine-tuned to effectively load tumor antigens and immunoadjuvants as cancer vaccines and significantly enhance the local antitumor efficacy of PDT, RT, RT-RDT, and CDT via generation of reactive oxygen species (ROS) for in situ cancer vaccination. These nMOF-based treatments are further combined with cancer immunotherapies to elicit systemic antitumor immunity. We discuss novel strategies to enhance light tissue penetration and overcome tumor hypoxia in PDT, to increase energy deposition and ROS diffusion in RT, to combine the advantages of PDT and RT to enable RT-RDT, and to trigger CDT by hijacking aberrant metabolic processes in tumors. Loading nMOFs with small-molecule drugs such as an indoleamine 2,3-dioxygenase inhibitor, the toll-like receptor agonist imiquimod, and biomacromolecules such as CpG oligodeoxynucleot...

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“…Then the immunotherapy agent called IDO, which could inhibit the express of indoleamine 2,3‐dioxygenase, was encapsulated into the channels of NMOFs, so as to achieve the synergistic effect of PDT and immunotherapy for inhabiting colorectal cancers. In addition to PDT/immunotherapy, some other therapies have also been combined with the NMOFs mediated PDT, especially chemotherapy, owing to that chemotherapeutic drugs could easily be encapsulated into the pores of NMOFs. Various experimental results turned out that the synergistic effect was better than the single therapy.…”

Section: Tumor Therapymentioning

confidence: 99%

Nanoscale Metal‐Organic Frameworks: Synthesis, Biocompatibility, Imaging Applications, and Thermal and Dynamic Therapy of Tumors

Tan

Meng

2020

Adv Funct Materials

121

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Nanoscale metal‐organic frameworks (NMOFs) have attracted increasing attention for biomedical applications due to their large specific surface area, good biocompatibility, adjustable structures, and diverse functions. By choosing appropriate metal ions and ligands, NMOFs can be synthesized and regulated to assist the diagnosis and treatment of cancer, acting as imaging agents, drug carriers, and cancer therapeutic agents. This review summarizes the recent advances of NMOFs in synthesis, biocompatibility, imaging, and applications in cancer therapies. Among these, the term “biocompatibility” is used to outline their various biological characteristics, and it is mainly discussed from the aspects of size and surface properties of NMOFs. The imaging section mainly emphasizes the application advantages of NMOFs as imaging agents in magnetic resonance, computed tomography, and fluorescence imaging. The applications of NMOFs in four cancer therapies, including phototherapy, radiotherapy, microwave therapy, and ultrasonic therapy, are addressed, especially for thermal and dynamic therapy. Finally, the prospects and challenges of NMOFs in imaging and cancer therapies are also discussed.

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A Nanoscale Metal–Organic Framework to Mediate Photodynamic Therapy and Deliver CpG Oligodeoxynucleotides to Enhance Antigen Presentation and Cancer Immunotherapy

Cited by 151 publications

References 34 publications

Nanomedicines based on nanoscale metal-organic frameworks for cancer immunotherapy

Nanomedicines based on nanoscale metal-organic frameworks for cancer immunotherapy

Nanoscale Metal–Organic Frameworks for Cancer Immunotherapy

Nanoscale Metal‐Organic Frameworks: Synthesis, Biocompatibility, Imaging Applications, and Thermal and Dynamic Therapy of Tumors

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