A nanoparticulate dual scavenger for targeted therapy of inflammatory bowel disease

Shi, Chengxin; Dawulieti, Jianati; Shi, Feiyu; Yang, Chao; Qin, Qian; Shi, Tongfei; Wang, Lizhao; Hu, Hanze; Sun, Madi; Li, Ren; Chen, Fangman; Zhao, Yawei; Liu, Feng; Li, Mingqiang; Mu, Lijun; Liú, Dan; Shao, Dan; Leong, Kam W.; She, Junjun

doi:10.1126/sciadv.abj2372

Cited by 93 publications

(64 citation statements)

References 52 publications

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“…At present, research on PDA is mainly focused on the cellular level, but there are few experimental studies on in vivo transplantation, and there are no studies evaluating its safety in vivo . New nanomedicine strategy shown to be effective in improving tissue inflammation in diseases ( Shi et al, 2022 ). We selected three different sites of rats to evaluate the safety of different transplantation sites.…”

Section: Discussionmentioning

confidence: 99%

Study on the Effect of PDA-PLGA Scaffold Loaded With Islet Cells for Skeletal Muscle Transplantation in the Treatment of Diabetes

Zhang

Guan

et al. 2022

Front. Bioeng. Biotechnol.

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At present, islet cells transplantation was limited by the way in which islet cells are implanted into the body, their ability to adapt to the microenvironment and the maintenance time for relieving diabetic symptoms. In order to solve this problem, we made PDA-PLGA scaffold loaded with islet cells and used it for skeletal muscle transplantation to investigate its therapeutic effect in the treatment of diabetes. The PLGA scaffold was prepared by the electrospinning method, and modified by polydopamine coating. A rat diabetic model was established to evaluate the efficacy of PDA-PLGA scaffold loaded with RINm5f islet cells through skeletal muscle transplantation. The results showed that the PDA-PLGA scaffold has good biosafety performance. At the same time, transplantation of the stent to the skeletal muscle site had little effect on the serum biochemical indicators of rats, which was conducive to angiogenesis. The PDA-PLGA scaffold had no effect on the secretory function of pancreatic islet cells. The PDA-PLGA scaffold carrying RINm5f cells was transplanted into the skeletal muscle of type I diabetic rats. 1 week after the transplantation of the PDA-PLGA cell scaffold complex, the blood glucose of the treatment group was significantly lower than that of the model group (p < 0.001) and lasted for approximately 3 weeks, which further indicated the skeletal muscle transplantation site was a new choice for islet cell transplantation in the future.

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Section: Discussionmentioning

confidence: 99%

Study on the Effect of PDA-PLGA Scaffold Loaded With Islet Cells for Skeletal Muscle Transplantation in the Treatment of Diabetes

Zhang

Guan

et al. 2022

Front. Bioeng. Biotechnol.

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“…Recently, NABP, as a positively charged nucleic acid scavenger, and has been used in various inflammatory diseases to block the excessive activation of innate immunity by molecular patterns (Lee et al, 2011). Compared with the soluble polycations (like PAMAM-G3), the improved NABP nanoparticles have better biological safety and NA scavenging capacity, and demonstrates an excellent therapeutic effect in rheumatoid arthritis (Liang et al, 2018;Peng et al, 2019), sepsis (Dawulieti et al, 2020;Liu F. et al, 2021), and inflammatory bowel disease (Shi et al, 2022). Therefore, it can be feasible to regulate inflammation through non-specific clearance of DAMPs and PAMPs.…”

Section: Blocking Pamps and Damps Has The Potential To Inhibit The Sy...mentioning

confidence: 99%

PAMPs and DAMPs as the Bridge Between Periodontitis and Atherosclerosis: The Potential Therapeutic Targets

Zhu

Huang

Zhao

2022

Front. Cell Dev. Biol.

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Atherosclerosis is a chronic artery disease characterized by plaque formation and vascular inflammation, eventually leading to myocardial infarction and stroke. Innate immunity plays an irreplaceable role in the vascular inflammatory response triggered by chronic infection. Periodontitis is a common chronic disorder that involves oral microbe-related inflammatory bone loss and local destruction of the periodontal ligament and is a risk factor for atherosclerosis. Periodontal pathogens contain numerous pathogen-associated molecular patterns (PAMPs) such as lipopolysaccharide, CpG DNA, and Peptidoglycan, that initiate the inflammatory response of the innate immunity depending on the recognition of pattern-recognition receptors (PRRs) of host cells. The immune-inflammatory response and destruction of the periodontal tissue will produce a large number of damage-associated molecular patterns (DAMPs) such as neutrophil extracellular traps (NETs), high mobility group box 1 (HMGB1), alarmins (S100 protein), and which can further affect the progression of atherosclerosis. Molecular patterns have recently become the therapeutic targets for inflammatory disease, including blocking the interaction between molecular patterns and PRRs and controlling the related signal transduction pathway. This review summarized the research progress of some representative PAMPs and DAMPs as the molecular pathological mechanism bridging periodontitis and atherosclerosis. We also discussed possible ways to prevent serious cardiovascular events in patients with periodontitis and atherosclerosis by targeting molecular patterns.

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“…Recently, an improved performance, targeted delivery of mesoporous organosilica nanoparticles (MONs) has been designed to be immunogenic by coating it with 4T1 breast cancer cell membrane while responsive to X-ray as the external activator that controlled the drug release ( Shao et al, 2020 ). An orally delivered diselenide-bridged MON conjugated to polyethyleneimine demonstrated the ability to scavenge pro-inflammatory cell-free-DNA and reactive oxygen species (ROS) in ulcerative colitis and Crohn’s disease mouse model ( Shi et al, 2022 ). In general, desirable characteristics of an NGDDS include non-toxic, biocompatible, having a robust synthetic pathway, tunable functionalization with any stimuli molecules or targeting ligands, customizable size, sufficient drug payload, ability to slowly release the drugs, and exhibit properties that can enhance solubility and permeability of the encapsulated drugs.…”

Section: Mesoporous Silica As the Next-generation Drug Delivery Systemmentioning

confidence: 99%

Biocompatible Supramolecular Mesoporous Silica Nanoparticles as the Next-Generation Drug Delivery System

Mohamed

Oo²,

Chatterjee³

et al. 2022

Front. Pharmacol.

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Supramolecular mesoporous silica nanoparticles (MSNs) offer distinct properties as opposed to micron-sized silica particles in terms of their crystal structure, morphology–porosity, toxicity, biological effects, and others. MSN biocompatibility has touched the pharmaceutical realm to exploit its robust synthesis pathway for delivery of various therapeutic molecules including macromolecules and small-molecule drugs. This article provides a brief review of MSN history followed by special emphasis on the influencing factors affecting morphology–porosity characteristics. Its applications as the next-generation drug delivery system (NGDDS) particularly in a controlled release dosage form via an oral drug delivery system are also presented and shall be highlighted as oral delivery is the most convenient route of drug administration with the economical cost of development through to scale-up for clinical trials and market launch.

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A nanoparticulate dual scavenger for targeted therapy of inflammatory bowel disease

Cited by 93 publications

References 52 publications

Study on the Effect of PDA-PLGA Scaffold Loaded With Islet Cells for Skeletal Muscle Transplantation in the Treatment of Diabetes

Study on the Effect of PDA-PLGA Scaffold Loaded With Islet Cells for Skeletal Muscle Transplantation in the Treatment of Diabetes

PAMPs and DAMPs as the Bridge Between Periodontitis and Atherosclerosis: The Potential Therapeutic Targets

Biocompatible Supramolecular Mesoporous Silica Nanoparticles as the Next-Generation Drug Delivery System

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