A nanocrystalline CdS thin film as a heterogeneous, recyclable catalyst for effective synthesis of dihydropyrimidinones and a new class of carbazolyl dihydropyrimidinonesviaan improved Biginelli protocol

Abstract

An improved Biginelli protocol for the efficient synthesis of a new class of carbazolyl dihydropyrimidinones mediated by CdS thin film nanoparticles deposited on the inner walls of a glass reactor as a recyclable, heterogeneous catalyst.

Design, synthesis, molecular docking, and spectral studies of new class of carbazolyl polyhydroquinoline derivatives as promising antibacterial agents with noncytotoxicity towards human mononuclear cells from peripheral blood

“…More recently, we have also reported nanocrystalline CdS thin film as an efficient, recyclable catalyst for the effective synthesis of new class of Biginelli compounds with high oral bioavailability. [22] In continuation of our search for finding new class of heterocyclic compounds with potential antibacterial activity, we now report carbazolyl-1,4-dihydropyridines (1,4-CDHPs), carbazolyl-1,8-dioxodecahydroacridine (CAD), and carbazolyl polyhydroquinoline (CPQ) derivatives as potential antibacterial agents with minimal cytotoxicity The reaction of carbazole aldehyde (1a) with ethyl acetoacetate (2a) and ammonium acetate (3a) was chosen as a model reaction to study the effect of temperature and solvent on the yield and rate of 1,4-CDHP synthesis. The reaction either did not progress or afforded poor yields in less polar solvents such as toluene and benzene at room temperature or even at higher temperatures.…”

Synthesis, structure, and optical properties of nanopowders CdS: xAl (x=0, 1, 5, 10, 15 and 20%) via the sol–gel technique

“…Also, the average crystallite size D estimated from Scherrer's relation: where, β is the full width at half maximum (FWHM) of the diffraction peak in radian and λ =0.15418 nm is the X-ray wavelength. The obtained values of D are compared with the results of pure CdS hexagonal nanocrystals prepared by several methods in previous articles (  3  47 nm) [24][25][26] . The average crystallite size D for pure and Al-doped CdS is almost unchanged (  34 nm) which supported that the crystals are in hexagonal structure.…”

Air‐stable zirconium (IV)‐salophen perfluorooctanesulfonate as a highly efficient and reusable catalyst for the synthesis of 3,4‐dihydropyrimidin‐2‐(1H)‐ones/thiones under solvent‐free conditions

“…In show the merit of the present study, the results of using complex 1 for the synthesis of product 5a by reacting benzaldehyde, ethyl acetoacetate, and urea with other homogeneous and heterogeneous catalysts were compared ( Table 4, entries [3][4][5][6][7][8][9][10][11][12][13][14]. According to the obtained results [7,9,13,24,27,[31][32][33][53][54][55] our catalyst shows better catalytic activity with a shorter reaction time using solvent-free conditions with good recyclability. Apparently, the long fluoroalkyl chain in the sulfonate must be responsible for the hydrophobicity and increasing the catalytic activity.…”