A nanocarrier based on poly(d,l-lactic-co-glycolic acid) for transporting Na+ and Cl− to induce apoptosis

Ma, Chen; Zhang, Yida; Jiao, Zhijuan; Ma, Chunmeng; Liu, Xiaoyan; Zhang, Haixia

doi:10.1016/j.cclet.2019.09.010

Cited by 9 publications

(1 citation statement)

References 45 publications

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“…PLGA, as a synthetic polymer, is one of the most widely used drug delivery carrier (Zeng et al, 2013 ; Cheng et al, 2018 ; Shi et al, 2020 ), which can transport proteins (Xu et al, 2020 ; Zhai et al, 2020 ), peptides (Cai et al, 2019 ; Zhang et al, 2020 ; Jin et al, 2021 ), bacterial or viral DNA (Koerner et al, 2019 ; Lu et al, 2020 ), and various anticancer drugs (Lee et al, 2018 ; Shakeri et al, 2020 ). PLGA is synthesized by random polymerization of lactic acid (LA) and glycolic acid (GA), which has good biocompatibility and biodegradability (Peng et al, 2018 ; Ma et al, 2020 ). PLGA is hydrolyzed into lactic acid and glycolic acid in vivo, and further metabolized into water and carbon dioxide through the tricarboxylic acid cycle, and finally excreted in the lung.…”

Section: Plga As Biodegradable Microsphere Carrier Materialsmentioning

confidence: 99%

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

Zhang²,

Sun³

et al. 2021

Drug Delivery

252

106

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Biodegradable microspheres have been widely used in the field of medicine due to their ability to deliver drug molecules of various properties through multiple pathways and their advantages of low dose and low side effects. Poly (lactic-co-glycolic acid) copolymer (PLGA) is one of the most widely used biodegradable material currently and has good biocompatibility. In application, PLGA with a specific monomer ratio (lactic acid and glycolic acid) can be selected according to the properties of drug molecules and the requirements of the drug release rate. PLGA-based biodegradable microspheres have been studied in the field of drug delivery, including the delivery of various anticancer drugs, protein or peptide drugs, bacterial or viral DNA, etc. This review describes the basic knowledge and current situation of PLGA biodegradable microspheres and discusses the selection of PLGA polymer materials. Then, the preparation methods of PLGA microspheres are introduced, including emulsification, microfluidic technology, electrospray, and spray drying. Finally, this review summarizes the application of PLGA microspheres in drug delivery and the treatment of pulmonary and ocularrelated diseases.

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Section: Plga As Biodegradable Microsphere Carrier Materialsmentioning

confidence: 99%

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

Zhang²,

Sun³

et al. 2021

Drug Delivery

252

106

View full text Add to dashboard Cite

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Implantable application of polymer‐based biosensors

Mei

Zhang

et al. 2021

Journal of Polymer Science

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Implantable sensors offer a great opportunity to extract physiological information from inside the body by real-time monitoring. With the demand for personal healthcare and point-of-care treatment, a long-term stable sensor of excellent mechanical and biological compatibility with human organs is urgently required. In contrast to rigid electronic devices using silicon or metallic materials, soft sensors are realized by flexible polymers in a simple way, endowing the implantable sensor with a tissue-mimetic structure. In this article, we systematically review the development of implantable electronic sensors based on polymer materials. The unique properties of polymers are introduced, followed by their applications in implantable device fabrication.Strategies to integrate polymers with implantable sensors, encompassing device interface, geometry, and integration, are also summarized. Furthermore, biosensing applications of polymer-based implantable devices are described, ranging from physical stimulus monitoring to biochemical analysis in vivo. Finally, we envision how advances in polymer materials may facilitate the development of intelligent sensors with broader applications in vivo.

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Phosphate imbalance conducting by BPs-based cancer-targeting phosphate anions carrier induces necrosis

Zhang

et al. 2021

Chinese Chemical Letters

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A nanocarrier based on poly(d,l-lactic-co-glycolic acid) for transporting Na+ and Cl− to induce apoptosis

Cited by 9 publications

References 45 publications

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

Implantable application of polymer‐based biosensors

Phosphate imbalance conducting by BPs-based cancer-targeting phosphate anions carrier induces necrosis

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