A mutually beneficial macrophages-mediated delivery system realizing photo/immune therapy

Wang, Xiudan; Lu, Junya; Mao, Yuling; Zhao, Qinfu; Chen, Caishun; Han, Jia-Jun; Han, Meiqi; Yuan, Huijuan; Wang, Siling

doi:10.1016/j.jconrel.2022.04.038

Cited by 11 publications

(8 citation statements)

References 36 publications

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“…M@C-HA/ICG showed outstanding anticancer efficacy by enhancing tumor accumulation. Moreover, cytomembrane damage caused by ROS, apoptosis induced by heat, and pro-inflammatory cytokine-mediated immunotherapy were observed [ 145 ].…”

Section: Natural Polymersmentioning

confidence: 99%

Smart Polymeric Nanoparticles in Cancer Immunotherapy

Shen

et al. 2023

Pharmaceutics

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Cancer develops with unexpected mutations and causes death in many patients. Among the different cancer treatment strategies, immunotherapy is promising with the benefits of high specificity and accuracy, as well as modulating immune responses. Nanomaterials can be used to formulate drug delivery carriers for targeted cancer therapy. Polymeric nanoparticles used in the clinic are biocompatible and have excellent stability. They have the potential to improve therapeutic effects while significantly reducing off-target toxicity. This review classifies smart drug delivery systems based on their components. Synthetic smart polymers used in the pharmaceutical industry, including enzyme-responsive, pH-responsive, and redox-responsive polymers, are discussed. Natural polymers derived from plants, animals, microbes, and marine organisms can also be used to construct stimuli-responsive delivery systems with excellent biocompatibility, low toxicity, and biodegradability. The applications of smart or stimuli-responsive polymers in cancer immunotherapies are discussed in this systemic review. We summarize different delivery strategies and mechanisms that can be used in cancer immunotherapy and give examples of each case.

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Section: Natural Polymersmentioning

confidence: 99%

Smart Polymeric Nanoparticles in Cancer Immunotherapy

Shen

et al. 2023

Pharmaceutics

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“…In this hybrid system, macrophages acted not only as vehicles but also as killers. 52 They prepared HA−carbon nanohybrids and loaded photosensitizer indocyanine green to produce C-HA/ ICG, which could polarize macrophages to M1 phenotype by low-molecular-weight HA and carbon nanoparticles. The hybrid system of macrophages and C-HA/ICG nanohybrids could effectively realize polarized macrophages-mediated synergistic PTT/photodynamic therapy.…”

Section: Versatile Hybrid Systems Of Polysaccharides and Inorganic Na...mentioning

confidence: 99%

“…Other hybrid systems composed of polysaccharides and inorganic nanoparticles, such as hydrogels, electrospun scaffolds, microneedles, and cell-mediated delivery systems also demonstrate great potential in diverse biomedical applications. These localized administration systems enable increased local retention and concentration of inorganic nanoparticles to enhance the therapeutic effects and avoid potential side effects …”

Section: Versatile Hybrid Systems Of Polysaccharides and Inorganic Na...mentioning

confidence: 99%

Hybrids of Polysaccharides and Inorganic Nanoparticles: From Morphological Design to Diverse Biomedical Applications

Zhao,

Jiao,

Chen

et al. 2023

Acc. Mater. Res.

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“…4,5 MCNs are excellent near-infrared (NIR) PTT agents that play an inhibitory role against tumors through induced hyperthermia, and thus show great potential as a non-invasive treatment method. [6][7][8][9][10] They have been widely used in tumor PTT and PTT-based combination therapy. 11 Meanwhile, a variety of methods have been reported to endow them with imaging ability, further expanding their applications.…”

Section: Introductionmentioning

confidence: 99%