Immunological gadolinium-doped mesoporous carbon nanoparticles for tumor-targeted MRI and photothermal-immune co-therapy

Song, Xiaoxi; Zhang, Chun; Xing, Mengyuan; He, Chaoliang; Wang, Dongxu; Chong, Lijuan; Zhang, Xiuli; Chen, Ming‐Hui; Li, Jingjing

doi:10.1039/d3tb00595j

Cited by 2 publications

(1 citation statement)

References 46 publications

(58 reference statements)

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“…To be used as an MRI CA model, Gd-MCNs were prepared by a one-step hard template method, with TEOS as silicon source, resorcinol and formaldehyde as carbon source, and Gd-Si-DTTA as Gd source. 27 Different from traditional hard template, which need to prepare hard template first and then repeated filling of template holes, the one-step hard template method realized the Gd doping and carbon filling at the same time. The morphology and nanostructure of Gd-MCNs were firstly observed by TEM.…”

Section: Resultsmentioning

confidence: 99%

MRI Directed Magnevist Effective to Study Toxicity of Gd-Doped Mesoporous Carbon Nanoparticles in Mice Model

Zhang,

Shi,

Chang

et al. 2023

IJN

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Purpose Magnetic resonance imaging (MRI) has been a valuable and widely used examination technique in clinical diagnosis and prognostic efficacy evaluation. The introduction of MRI contrast agent (CA) improves its sensitivity obviously, particularly with the development of nano-CA, which presents higher contrast enhancement ability. However, systematical evaluation of their toxicity is still limited, hampering their further translation in clinics. Methods In this paper, to systematically evaluate the toxicity of nano-CA, Gd-doped mesoporous carbon nanoparticles (Gd-MCNs) prepared by a one-step hard template method were introduced as a model and clinically used MRI CA, Magnevist (Gd-DTPA) as control. Their in vitro blood compatibility, cellular toxicity, DNA damage, oxidative stress, inflammation response as well as in vivo toxicity and MR imaging behaviors were studied and compared. Results The experimental results showed that compared with Gd-DTPA, Gd-MCNs displayed negligible influence on the red blood cell shape, aggregation, BSA structure, macrophage morphology and mitochondrial function. Meanwhile, limited ROS and inflammatory cytokine production also illustrated the cellular compatibility of Gd-MCNs. For in vivo toxicity evaluation, Gd-MCNs presented acceptable in vivo biosafety even under 12 times injection for 12 weeks. More importantly, at the same concentration of Gd, Gd-MCNs displayed better contrast enhancement of tumor than Gd-DTPA, mainly coming from its high MRI relaxation rate which is nearly 9 times that of Gd-DTPA. Conclusion In this paper, we focus on the toxicity evaluation of MRI nano-CA, Gd-MCNs from different angles. With Gd-DTPA as control, Gd-MCNs appeared to be highly biocompatible and safe nanoparticles that possessed promising potentials for the use of MRI nano-CA. In the future, more research on the long-term genotoxicity and the fate of nanoparticles after being swallowed should be performed.

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Section: Resultsmentioning

confidence: 99%