A mussel-inspired supramolecular hydrogel with robust tissue anchor for rapid hemostasis of arterial and visceral bleedings

Qiao, Ziwen; Lv, Xueli; He, Shaohua; Bai, Shumeng; Liu, Xiaochen; Hou, Linxi; He, Jingjing; Tong, Dongmei; Ruan, Renjie; Zhang, Jin; Ding, Jianxun; Yang, Huanghao

doi:10.1016/j.bioactmat.2021.01.039

Cited by 171 publications

(127 citation statements)

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“…For wound sealing, the gelation time of the hydrogel adhesive can affect the hemostasis of damaged tissues. Some commercial tissue adhesives have strong adhesion capacity, but the gelation time is too slow, which may not be enough to stop bleeding in the event of a sudden loss of blood ( Qiao et al, 2021 ). Here, the gelation time of 20% Gel-ADH/OSA 1:1 and 20% Gel-ADH/OSA 2:1 was under 10 s. The Gel-ADH/OSA hydrogel with higher concentration had more amino and aldehyde groups to accelerate the Schiff base reaction rate.…”

Section: Resultsmentioning

confidence: 99%

Injectable Hydrogel Based on Modified Gelatin and Sodium Alginate for Soft-Tissue Adhesive

et al. 2021

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To assist or replace the traditional suture techniques for wound closure, soft-tissue adhesives with excellent adhesion strength and favorable biocompatibility are of great significance in biomedical applications. In this study, an injectable hydrogel tissue adhesive containing adipic acid dihydrazide–modified gelatin (Gel-ADH) and oxidized sodium alginate (OSA) was developed. It was found that this tissue adhesive possessed a uniform structure, appropriate swelling ratio, good injectability, and excellent hemocompatibility and cytocompatibility. The adhesion capacity of the developed adhesive with optimized component and concentration was stronger than that of the commercial adhesive Porcine Fibrin Sealant Kit. All these results suggested that the developed hydrogel was a promising candidate for a soft-tissue adhesive.

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Section: Resultsmentioning

confidence: 99%

Injectable Hydrogel Based on Modified Gelatin and Sodium Alginate for Soft-Tissue Adhesive

et al. 2021

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“…EPL/PCL/HA scaffolding promoted tissue growth inside the defects, thus accelerating tissue growth [47]. There are several possible mechanisms that may explain this property: first, our previous study has showed that the EPL/ PCL/HA scaffold surface has enhanced hydrophilicity [27], which was due to HA offering the free -OH group and the amidogens of EPL bound with proteoglycans on the cells' surface [48][49][50], making it easy to maintain the scaffold structure and improving cell adhesion. Second, EPL can directly interact with cell lipid bilayers, preventing cells from agglomerating into spheres through electrostatic attraction and other functions.…”

Section: Discussionmentioning

confidence: 99%

The immunogenic reaction and bone defect repair function of ε-poly-L-lysine (EPL)-coated nanoscale PCL/HA scaffold in rabbit calvarial bone defect

Tian

Wang

Jiang

et al. 2021

J Mater Sci: Mater Med

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Tissue engineering is a promising strategy for bone tissue defect reconstruction. Immunogenic reaction, which was induced by scaffolds degradation or contaminating microorganism, influence cellular activity, compromise the efficiency of tissue engineering, or eventually lead to the failure of regeneration. Inhibiting excessive immune response through modulating scaffold is critical important to promote tissue regeneration. Our previous study showed that ε-poly-L-lysine (EPL)-coated nanoscale polycaprolactone/hydroxyapatite (EPL/PCL/HA) composite scaffold has enhanced antibacterial and osteogenic properties in vitro. However, the bone defect repair function and immunogenic reaction of EPL/PCL/HA scaffolds in vivo remains unclear. In the present study, three nanoscale scaffolds (EPL/PCL/HA, PCL and PCL/HA) were transplanted into rabbit paraspinal muscle pouches, and T helper type 1 (Th1), T helper type 2 (Th2), T helper type 17 (Th17), and macrophage infiltration were analyzed after 1 week and 2 weeks to detect their immunogenic reaction. Then, the different scaffolds were transplanted into rabbit calvarial bone defect to compare the bone defect repair capacities. The results showed that EPL/PCL/HA composite scaffolds decreased pro-inflammatory Th1, Th17, and type I macrophage infiltration from 1 to 2 weeks, and increased anti-inflammatory Th2 infiltration into the regenerated area at 2 weeks in vivo, when compared to PCL and PCL/HA. In addition, EPL/PCL/HA showed an enhanced bone repair capacity compared to PCL and PCL/HA when transplanted into rabbit calvarial bone defects at both 4 and 8 weeks. Hence, our results suggest that EPL could regulate the immunogenic reaction and promote bone defect repair function of PCL/HA, which is a promising agent for tissue engineering scaffold modulation.

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“…After realizing the healing mechanism of acute and chronic wounds, researchers have attempted to accelerate the healing velocity and effect through various strategies. [ 67 ] Here, we describe the applications to wound healing of edible materials owing to their antibacterial, anti‐inflammatory, and antioxidant properties.…”

Section: Applications Of Edible Materials In Skin Wound Healingmentioning

confidence: 99%

Edible Materials in Tissue Regeneration

Cheng

Gao

et al. 2021

Macromolecular Bioscience

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Edible materials have attracted increasing attention because of their excellent properties including availability, biocompatibility, biological activity, and biodegradability. Natural polysaccharides, phenolic compounds, and proteins are widely used in tissue regeneration. To better characterize their healing effect, this review article describes the applications of edible materials in tissue regeneration including wound healing and bone tissue regeneration. As an introduction to the topic, their sources and main bioactive properties are discussed. Then, the mechanism by which they facilitate wound healing based on their hemostasis, antibacterial, anti‐inflammatory, and antioxidant properties is systematically investigated. Moreover, a more comprehensive discussion is presented on the approaches by which edible materials can be used as scaffolds or agents for the provision of the components of natural bones for regulating the level of osteogenesis‐related cytokines to enhance bone repair. Finally, the prospects of edible materials for tissue regeneration are discussed.

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A mussel-inspired supramolecular hydrogel with robust tissue anchor for rapid hemostasis of arterial and visceral bleedings

Cited by 171 publications

References 50 publications

Injectable Hydrogel Based on Modified Gelatin and Sodium Alginate for Soft-Tissue Adhesive

Injectable Hydrogel Based on Modified Gelatin and Sodium Alginate for Soft-Tissue Adhesive

The immunogenic reaction and bone defect repair function of ε-poly-L-lysine (EPL)-coated nanoscale PCL/HA scaffold in rabbit calvarial bone defect

Edible Materials in Tissue Regeneration

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