Edible Materials in Tissue Regeneration

Abstract

Edible materials have attracted increasing attention because of their excellent properties including availability, biocompatibility, biological activity, and biodegradability. Natural polysaccharides, phenolic compounds, and proteins are widely used in tissue regeneration. To better characterize their healing effect, this review article describes the applications of edible materials in tissue regeneration including wound healing and bone tissue regeneration. As an introduction to the topic, their sources and main bioactive properties are discussed. Then, the mechanism by which they facilitate wound healing based on their hemostasis, antibacterial, anti‐inflammatory, and antioxidant properties is systematically investigated. Moreover, a more comprehensive discussion is presented on the approaches by which edible materials can be used as scaffolds or agents for the provision of the components of natural bones for regulating the level of osteogenesis‐related cytokines to enhance bone repair. Finally, the prospects of edible materials for tissue regeneration are discussed.

Glycosaminoglycan-Based Hydrogel Delivery System Regulates the Wound Microenvironment to Rescue Chronic Wound Healing

“…Natural biomaterials such as polyphenolic compounds and natural polysaccharides, which possess similar biological and chemical properties to natural tissues, are widely used in tissue repair . Curcumin, a kind of natural polyphenol, is known as the main active ingredient of the Chinese herb turmeric.…”

“…12,13 Natural biomaterials such as polyphenolic compounds and natural polysaccharides, which possess similar biological and chemical properties to natural tissues, are widely used in tissue repair. 14 Curcumin, a kind of natural polyphenol, is known as the main active ingredient of the Chinese herb turmeric. Numerous data prove that curcumin has a wide range of pharmacological activities, including antioxidant, anti-inflammatory, and antibacterial, and it can effectively promote wound healing.…”

Natural Soybean Milk-Derived Bioactive Coatings for Enhanced Wound Healing

“…The concept of homology of medicine and food has been put forward in Traditional Chinese medicine for thousands of years and has been tested for a long time. − In recent years, edible biomaterials have received much interest in the field of skin tissue regeneration because of their excellent biocompatibility, low cost, easy availability, and high biological activity. − Compared to the synthetic wound dressing, they are more natural, safe, and easy-to-apply. Soybeans, as one of the most common foodborne biomaterials, have attracted attention for enhanced skin healing.…”

“…Soybeans, as one of the most common foodborne biomaterials, have attracted attention for enhanced skin healing. Their abundant soybean protein can be used as an alternative peptide mimetic in human extracellular matrix (ECM) to promote cell adhesion, proliferation, and migration, which is essential for cutaneous wound healing. ,− Therefore, soybean protein, which has been studied extensively, has displayed excellent characteristics in hydrogels, films, and adhesives used in tissue engineering − In addition, soybeans are rich in soybean oil (unsaturated fatty acids and tocopherols), isoflavone, saponin, and other bioactive components, which are closely related to the antioxidant properties essential to resist redox imbalance of the wound bed microenvironment. − For example, soybean-derived tofu bioscaffolds have been studied for their antioxidant effect on skin wounds. − …”

3D Printing of PLLA/Biomineral Composite Bone Tissue Engineering Scaffolds

“…Biominerals are functional or pathological crystalline solids existing in organisms. Recently, natural biomaterials have often been utilized for tissue engineering scaffolds [29][30][31][32]. Natural biominerals, such as shells and pearls, have attracted increasing attention in biomedical applications due to their wide availability, low price and superior biophysical properties.…”