A mussel-inspired double-crosslinked tissue adhesive intended for internal medical use

Fan, Changjiang; Fu, Jiayin; Zhu, Wenzhen; Wang, Dong‐An

doi:10.1016/j.actbio.2016.02.003

Cited by 224 publications

(156 citation statements)

References 51 publications

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“…As reported in previous studies on surgical sealants, these tests were performed with standard tissues or tissue substitutes, respectively, in order to get reliable data on the general sealing potential of the gelatin-based adhesives [53–55]. Aiming to determine the sealing potential of GelMA hydrogels on the target tissue lung, additional in vivo experiments were conducted in two different animal models with lung lesions.…”

Section: Discussionmentioning

confidence: 99%

A highly adhesive and naturally derived sealant

et al. 2017

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Conventional surgical techniques to seal and repair defects in highly stressed elastic tissues are insufficient. Therefore, this study aimed to engineer an inexpensive, highly adhesive, biocompatible, and biodegradable sealant based on a modified and naturally derived biopolymer, gelatin methacryloyl (GelMA). We tuned the degree of gelatin modification, prepolymer concentration, photoinitiator concentration, and crosslinking conditions to optimize the physical properties and adhesion of the photocrosslinked GelMA hydrogels. Following ASTM standard tests that target wound closure strength, shear resistance, and burst pressure, GelMA sealant was shown to exhibit adhesive properties that were superior to clinically used fibrin- and poly(ethylene glycol)-based glues. Chronic in vivo experiments in small as well as translational large animal models proved GelMA to effectively seal large lung leakages without the need for sutures or staples, presenting improved performance as compared to fibrin glue, poly(ethylene glycol) glue and sutures only. Furthermore, high biocompatibility of GelMA sealant was observed, as evidenced by a low inflammatory host response and fast in vivo degradation while allowing for adequate wound healing at the same time. Combining these results with the low costs, ease of synthesis and application of the material, GelMA sealant is envisioned to be commercialized not only as a sealant to stop air leakages, but also as a biocompatible and biodegradable hydrogel to support lung tissue regeneration.

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Section: Discussionmentioning

confidence: 99%

A highly adhesive and naturally derived sealant

et al. 2017

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“…Our recent works have highlighted the major functionalities of catechol side groups in forming polymeric networks and tissue chemical bonding, revealing strategies for facile synthesis of catechol-functionalized biodegradable polymers with greatly improved wet adhesion strengths [11–15]. However, the prohibitive costs of such compounds [4–8] and neurological effects of dopamine pose concerns on the commercialization of such catechol-functionalized tissue adhesives [16].…”

Section: Introductionmentioning

confidence: 99%

Development of tannin-inspired antimicrobial bioadhesives

et al. 2018

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This manuscript describes the development of a new family of tannin-inspired antimicrobial bioadhesives derived from a facile, one-step Michael addition of tannic acid and gelatin under oxidizing conditions and crosslinked by silver nitrate. Our strategy is new and can be easily extended to other polymer systems, low-cost and readily scalable, and eliminate the concerns of potential neurological effect brought by mussel-inspired strategy due to the inclusion of dopamine. The tannin-inspired gelatin bioadhesives hold great promise for a number of applications in wound closure, tissue sealant, hemostasis, antimicrobial and cell/drug delivery, and would be interested to the readers from biomaterials, tissue engineering, and drug delivery area.

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“…The work contains a diverse array of modification methods, the most popular of which are physicochemical methods, enzyme treatments, and chemical cross-linking [8][9][10]. Among these modifications, chemical cross-linking appears to be the most effective.…”

Section: Introductionmentioning

confidence: 98%

Multiple crosslinking bionanocomposites reinforced with mussel‐inspired poly(dopamine) surface modified nanoclay: Construction, properties, and characterization

Zhong

Kang

et al. 2017

Polymer Composites

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This article reports a bioinspired strategy for the preparation of robust soy protein isolate (SPI) based nanocomposites using a poly(dopamine) coating montmorillonite (D-MMT) as reinforcement and ferric ion (Fe (III) ) as a coordination crosslinking center. Typically, the catechol groups present on MMT provide multiple cross-linking reaction sites for bio-nanocomposites reinforcement: Coordination among Fe (III) -catechol interactions as well as covalent interactions based on the Michael addition/ Schiff base reaction or hydrogen-bonded between D-MMT and the SPI matrix. The morphological, mechanical, hydrophobic, water-resistant, and thermal behaviors of the resultant SPI-based nanocomposites were investigated. The interaction between D-MMT and the SPI matrix was investigated via the scanning electron microscopy and atomic force microscopy. The results showed that, with 5 wt% D-MMT loading, the tensile strength, and elasticity modulus of the SPI-based nanocomposite films increased by 75.2 and 135.2%, respectively, compared with the control. The enhanced mechanical properties of the obtained modified films were, in fact, a result of the multiple cross-linking system, as confirmed by the Fourier transform infrared spectroscopy and solid-state 13

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A mussel-inspired double-crosslinked tissue adhesive intended for internal medical use

Cited by 224 publications

References 51 publications

A highly adhesive and naturally derived sealant

A highly adhesive and naturally derived sealant

Development of tannin-inspired antimicrobial bioadhesives

Multiple crosslinking bionanocomposites reinforced with mussel‐inspired poly(dopamine) surface modified nanoclay: Construction, properties, and characterization

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