A multitechnique evaluation of topical corticosteroid treatment

Josse, Gwendal; Rouvrais, C.; Mas, Amandine; Haftek, Marek; Delalleau, Alexandre; Ferraq, Y.; Ossant, F.; George, Jerome St; Lagarde, Jean Michel; Schmitt, Anne

doi:10.1111/j.1600-0846.2008.00326.x

Cited by 14 publications

(14 citation statements)

References 9 publications

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“…This method has previously been used in similar type studies (11)(12)(13). For obtaining skin data on the forearm, the distance between epicondylos medialis humerii and processus styleoideus radii was measured.…”

Section: Subjects and Designmentioning

confidence: 99%

Skin Thickness in Children Treated With Daily or Periodical Inhaled Budesonide for Mild Persistent Asthma. The Helsinki Early Intervention Childhood Asthma Study

et al. 2010

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ABSTRACT:In adults, asthma treatment with high doses of inhaled corticosteroids has resulted in dermal thinning. The aim of this study was to investigate the skin thickness in children with asthma during budesonide treatment. In a double-blind study, 113 children, 5-10 y old, with persistent asthma received budesonide 400 g twice daily for 1 mo and thereafter 200 g twice daily for 5 mo. Thereafter, 56 children received 100 g twice daily for 1 y, whereas 57 other children used budesonide periodically for exacerbations. An additional 54 children were treated with disodium cromoglycate (DSCG) for 18 mo. Skin thickness was measured on each forearm before and after treatment for 6, 12, and 18 mo using a 20-MHz high-resolution ultrasonic device. The initial 6-mo budesonide treatment resulted in a greater reduction in mean skin thickness in the forearms compared with DSCG (right: Ϫ35.9 versus Ϫ5.9 m; p ϭ 0.004; left: Ϫ30.6 versus Ϫ7.3 m; p ϭ 0.03). At month 18, the inter-group differences were no longer significant. Budesonide inhalations in daily doses of 400 -800 g in prepubertal children with newly detected asthma may cause minor dermal thinning. The changes were reversible during low dose or periodic treatment with budesonide. (Pediatr Res 67: 221-225, 2010)

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Section: Subjects and Designmentioning

confidence: 99%

Skin Thickness in Children Treated With Daily or Periodical Inhaled Budesonide for Mild Persistent Asthma. The Helsinki Early Intervention Childhood Asthma Study

et al. 2010

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“…In the present study, the use of sonoelastography to meet the aforementioned need relies on the observation that steroid-induced dermal atrophy is associated with loss of dermal elasticity [37][38][39]. Josse et al [38] found a good correlation between skin mechanical properties and histological assessment in atrophic skin.…”

Section: Discussionmentioning

confidence: 95%

“…Josse et al [38] found a good correlation between skin mechanical properties and histological assessment in atrophic skin.…”

Section: Discussionmentioning

confidence: 96%

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Conventional ultrasonography and sonoelastography in the assessment of plaque psoriasis under topical corticosteroid treatment – work in progress

et al. 2014

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Aims: The objective of the study was to compare the efficiency of 20 MHz skin ultrasonography and 40 MHz conventional ultrasonography in the assessment of plaque psoriasis and to assess the efficiency of 40 MHz real-time sonoelastography in the early detection of steroid-induced skin atrophy in psoriatic plaques. Patients and methods: Ultrasonographic blinded evaluation was performed on 16 plaques in three consecutive patients, at baseline and after hydrocortisone acetate 1% ointment six-week application. The parameters were epidermal and dermal thicknesses for gray-scale ultrasonography and strain ratio for sonoelastography. Strain ratio was computed between the dermis and the adjacent hypodermis. Student's t-test for paired samples was performed. A confidence level of p<.05 was considered significant. Results: At follow-up, epidermal thickness was significantly reduced with 20 MHz (p = .002) and 40 MHz sonography (p = .032), while dermal thickness varied insignifcantly with 20 MHz (p = .35) and 40 MHz sonography (p = .33). Measurements at 40 MHz were significantly higher than their 20 MHz counterparts at baseline (epidermis: p < .001; dermis: p = .003) and at follow-up (epidermis: p < .001; dermis: p = .001). Strain ratio revealed no significant change of dermal elasticity (p = .96). Conclusions: Although epidermal and dermal measurements varied significantly with 20 MHz and 40 MHz ultrasonography, both techniques efficiently quantified treatment response by measuring the reduction of epidermal thickness. Sonoelastographic findings were consistent with the expected outcome of short-term use of low-potency corticosteroid. Further studies are recommended.

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“…4 The in vivo characterization of corticosteroid-induced skin modifications at both cellular and extracellular levels and the dynamical study of these effects (e.g., their appearance and disappearance) require the use of 3-D noninvasive imaging methods. Optical coherence tomography 5 and confocal microscopy 6 can reveal, for example, epidermis thinning or the reduced size of the keratinocytes. However, since they lack specificity, they cannot provide access to other modifications induced in the cells or the elastic and collagen fibers networks.…”

Section: Introductionmentioning

confidence: 99%

In vivo multiphoton imaging of human skin: assessment of topical corticosteroid-induced epidermis atrophy and depigmentation

et al. 2012

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Abstract. Multiphoton microscopy has emerged in the past decade as a promising tool for noninvasive skin imaging. Our aim was to evaluate the potential of multiphoton microscopy to detect topical corticosteroids side effects within the epidermis and to provide new insights into their dynamics. Healthy volunteers were topically treated with clobetasol propionate on a small region of their forearms under overnight occlusion for three weeks. The treated region of each patient was investigated at D0, D7, D15, D22 (end of the treatment), and D60. Our study shows that multiphoton microscopy allows for the detection of corticoid-induced epidermis modifications: thinning of stratum corneum compactum and epidermis, decrease of keratinocytes size, and changes in their morphology from D7 to D22. We also show that multiphoton microscopy enables in vivo three-dimensional (3-D) quantitative assessment of melanin content. We observe that melanin density decreases during treatment and almost completely disappears at D22. Moreover, these alterations are reversible as they are no longer present at D60. Our study demonstrates that multiphoton microscopy is a convenient and powerful tool for noninvasive 3-D dynamical studies of skin integrity and pigmentation.

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A multitechnique evaluation of topical corticosteroid treatment

Abstract: Similar dynamics of skin modification during corticosteroid treatment was observed with very different techniques. Moreover, the potential of RF ultrasound analysis and mechanical skin measurement for characterizing skin structural and functional impairments has been evaluated.

Cited by 14 publications

References 9 publications

Skin Thickness in Children Treated With Daily or Periodical Inhaled Budesonide for Mild Persistent Asthma. The Helsinki Early Intervention Childhood Asthma Study

Skin Thickness in Children Treated With Daily or Periodical Inhaled Budesonide for Mild Persistent Asthma. The Helsinki Early Intervention Childhood Asthma Study

Conventional ultrasonography and sonoelastography in the assessment of plaque psoriasis under topical corticosteroid treatment – work in progress

In vivo multiphoton imaging of human skin: assessment of topical corticosteroid-induced epidermis atrophy and depigmentation

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