A multisite trial of atomoxetine and parent training in children with autism spectrum disorders: Rationale and design challenges

Treating aggression in persons with autism spectrum disorders: A review

“…Thirteen of the papers reported on the treatment of one or two individuals (Braithwaite & Richdale, 2000;Davis et al, 2013;Falcomata, Roane, Muething, Stephenson, & Ing, 2012;Fisher, Lindauer, Alterson, & Thompson, 1998;Foxx & Garito, 2007;Foxx & Meindl, 2007;Hittner, 1994;Kern, Carberry, & Haidara, 1997;Kuhn, Hardesty, & Sweeney, 2009;Luiselli, Blew, Keane, Thibadeau, & Holzman, 2000;Matson, LoVullo, Boisjoli, & Gonzales, 2008;Robertson, Wehby, & King, 2013;Sigafoos & Meikle, 1996), and two studies involved 100 or more people Silverman et al, 2014). The higher number of participated studies involved drug treatments (Arnold et al, 2003;Hellings et al, 2005;King & Davanzo, 1996;Marcus et al, 2009;McDougle et al, 1996;McDougle, Kem, & Posey, 2002;McDougle et al, 1998;Owen et al, 2009;Silverman et al, 2014;Troost et al, 2005), while the low number studies were largely psychologically based interventions. Again, this makes sense in that drug interventions for aggression are far less time intensive than psychologically based treatments.…”

“…For example, Hittner (1994) described a combination of imipramine and behavior modification for one adult with autism, and Silverman et al (2014) described the use of atomoxetine and parent training for 128 children with autism, PDD-NOS, or Asperger's syndrome. This area is one that deserves a lot more attention from researchers and funding bodies.…”

“…Sixteen of the reviewed studies used psychologically based therapies; one paper employed music (Lundqvist et al, 2009) while the other 15 papers relied on ABA principles and procedures (Braithwaite & Richdale, 2000;Davis et al, 2013;Falcomata et al, 2012;Fisher et al, 1998;Foxx & Garito, 2007;Foxx & Meindl, 2007;Fulton, Eapen, Walter, & Rogers, 2014;Hanley, Jin, Vanselow, & Hanratty, 2014;Hittner, 1994;Kern et al, 1997;Kuhn et al, 2009;Matson, LoVullo, et al, 2008;Robertson et al, 2013;Silverman et al, 2014;Sigafoos & Meikle, 1996). Two papers that used punishment procedures (i.e., overcorrection, physical restraint) were papers by Foxx and colleagues (Foxx & Garito, 2007;Foxx & Meindl, 2007).…”

Caregiver Satisfaction with a Multisite Trial of Atomoxetine and Parent Training for Attention-Deficit/Hyperactivity Disorder and Behavioral Noncompliance in Children with Autism Spectrum Disorder

“…We have previously described the background, methods, and child outcomes from CHARTS (Handen et al 2015;Silverman et al 2014). Briefly, CHARTS was a 10 week, parallel-groups, randomized, multisite trial.…”

“…CHARTS was a randomized clinical trial (RCT) conducted at three sites: The University of Pittsburgh Medical Center, the Ohio State University's Nisonger Center, and the University of Rochester Medical Center (for more information see Silverman et al 2014).…”