A multisite case report on the clinical use of sevoflurane in dogs

Kr, Branson; Je, Quandt; Ea, Martinez; Carroll, GL; Cm, Trim; Dodam,; Hartsfield, Sandee M.; Ns, Matthews; Mackenthun, A; Mh, Beleau

doi:10.5326/15473317-37-5-420

Cited by 18 publications

(27 citation statements)

References 19 publications

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“…Sevoflurane usually causes a dose-dependent decrease in arterial blood pressure (Branson et al, 2001). Although, Rezende (2004) observed stability for MAP in dogs anesthetized with 1.5 MAC of sevoflurane, differing from this study that administered the same dose, but recorded, from T20 on, MAP values lower than at T0.…”

Section: Discussioncontrasting

confidence: 51%

“…It's low bloodgas solubility coefficient (0.68) provides rapid anesthetic induction and recovery, with minimal irritation of the upper airways, low incidence of coughing and laryngospasm, fast control of anesthetic depth and preservation of the spontaneous ventilation (Charles and Fallon, 2000). This inhalant anesthetic has a dosedependent negative inotropic effect (Hanouz et al, 2000), increasing coronary blood flow and decreasing myocardial oxygen consumption (Crystal et al, 2000), but it decreases arterial blood pressure and systemic vascular resistance (Branson et al, 2001). …”

Section: Introductionmentioning

confidence: 99%

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Intracranial variables in propofol or sevoflurane-anesthestized dogs subjected to subarachnoid administration of iohexol

Nunes

Leite²,

Paula³

et al. 2011

Arq. Bras. Med. Vet. Zootec.

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Intracranial variables in propofol or ABSTRACTThe effects of subarachnoid administration of iohexol on intracranial hemodynamic in dogs anesthetized with propofol or sevoflurane were evaluated. Thirty adult animals (10.92.9kg) were distributed into two groups: PG, where propofol was used for induction (100.5mg/kg), followed by a continuous rate infusion at 0.550.15mg/kg/hour, and SG, where sevoflurane was administered for induction (2.5 MAC) and for anesthetic maintenance (1.5 MAC). A fiberoptic catheter was implanted on the right superficial cerebral cortex to monitor intracranial pressure (ICP). After 30 minutes, cerebrospinal fluid (CSF) was collected at the cisterna magna and iohexol was injected. The measurements were performed before CSF collection (TA), after the iohexol injection (T0), and at 10-minute intervals (T10 to T60). Intracranial pressure decreased at T0 in SG. Cerebral perfusion pressure at T0 was higher than at TA, T50 and T60 in PG, but in SG, the mean value at T0 was higher than the ones from T20 to T60. Mean arterial pressure at T0 was higher than at TA in PG, while in SG, the values from T20 to T60 were lower than at T0. The heart rate at T60 was lower than at T0 in PG. Cardiac output at TA was lower than at T60 in SG. The cerebrospinal fluid collection and administration of iohexol promoted decrease in intracranial pressure in sevolflurane-anesthetized dogs and increase in cerebral perfusion pressure in propofol-anesthetized dogs.Keywords: anesthesia, dogs, cerebral autoregulation, myelography Palavras-chave: cão, anestesia, autoregulação cerebral, mielografia RESUMO Avaliaram-se os efeitos da administração subaracnóidea de iohexol sobre a hemodinâmica intracraniana em cães anestesiados com propofol ou sevofluorano. Trinta e dois animais (10,9±2,9kg) foram distribuídos em dois grupos: no GP, o propofol foi usado para indução, 100.5mg/kg, seguido por infusão contínua, 0,55±0,15mg/kg/min; no GS, o sevofluorano foi administrado para indução, 2,5 CAM, e manutenção, 1,5 CAM, da anestesia. O cateter de fibra óptica foi implantado na superfície direita do córtex cerebral para monitorar a pressão intracraniana (PIC). Após 30 minutos, o fluido cerebroespinhal (FCS) foi coletado da cisterna magna e o iohexol injetado. As mensurações ocorreram antes da coleta do FCS (TA), depois da injeção de iohexol (T0) e em intervalos de 10 minutos (T10 a T60

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Section: Discussioncontrasting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Intracranial variables in propofol or sevoflurane-anesthestized dogs subjected to subarachnoid administration of iohexol

Nunes

Leite²,

Paula³

et al. 2011

Arq. Bras. Med. Vet. Zootec.

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“…During the last decade, clinical use of sevoflurane has been spreading in veterinary species such as horses [8,12,18,27], cats [13] and dogs [5,6]. Sevoflurane is minimally metabolized and easily cleared in animals; however, it should be remembered that sevoflurane causes dose-dependent hypotension, hypoventilation, impaired cardiac contractility and hypothermia [16].…”

mentioning

confidence: 99%

Minimum Alveolar Concentration for Blunting Adrenergic Responses (MAC-BAR) of Sevoflurane in Dogs

Yamashita

Furukawa

Itami

et al. 2012

The Journal of Veterinary Medical Science

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ABSTRACT. It is well known that heart rate or arterial blood pressure may increase in response to surgical stimulation despite the absence of a purposeful movement. However, there is limited information regarding anesthetic requirement for blunting adrenergic response in dogs. This study was designed to compare the minimum alveolar concentrations of sevoflurane required to prevent autonomic response (MAC-BAR) and purposeful movement (MAC) in dogs. Sevoflurane MAC-BAR and MAC were determined in 5 beagle dogs by judging dogs' response to a noxious electrical stimulus applied to the gingiva. The sevoflurane MAC-BAR was significantly higher than MAC (3.33 ± 0.48 vs 2.10 ± 0.28%, P=0.005). These results suggested that autonomic responses occurred at sevoflurane anesthetic concentrations at which purposeful movements were absent.

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“…During the last decade, clinical use of sevoflurane has been spreading in veterinary species such as horses [3,14,24,31], cats [15] and dogs [1,2]. Sevoflurane is minimally metabolized and easily cleared in animals; however, it should be remembered that sevoflurane causes dose-dependent hypotension, hypoventilation, impaired cardiac contractility and hypothermia [21].…”

mentioning

confidence: 99%

“…The tube passed through the endotracheal tube so that its tip rested in the thoracic portion of the trachea. A side-stream capnograph and anesthetic agent monitor were used to determine respiratory rate, PETCO 2 and ETSEV. The anesthetic agent monitor was calibrated immediately prior to each sevoflurane MAC determination.…”

mentioning

confidence: 99%

Effect of Age on Minimum Alveolar Concentration (MAC) of Sevoflurane in Dogs

Yamashita

Iwasaki

Umar

et al. 2009

The Journal of Veterinary Medical Science

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ABSTRACT. It is well known that the minimum alveolar concentration (MAC) of inhalation anesthetic decreases with increasing age. However, there is limited information regarding the effect of age on MAC in dogs. This study was designed to determine the effect of age on sevoflurane MAC in dogs. MAC was determined in 6 young (2 years old) and 6 old beagle dogs (8 to 10 years old) under artificial ventilation. Anesthesia was induced via mask induction and maintained with sevoflurane in oxygen, and MAC was determined by using a tail clamp method. The sevoflurane MAC for the older dogs was significantly less than that for the younger dogs (1.86  0.29% vs 2.25  0.15%, P=0.007). The MAC of sevoflurane is profoundly affected by age in dogs.KEY WORDS: aging, anesthesia and analgesia, canine, minimum alveolar concentration (MAC), sevoflurane.J. Vet. Med. Sci. 71(11): 1509-1512, 2009 Sevoflurane is a volatile anesthetic agent with a relatively low blood/gas solubility coefficient resulting in rapid induction and recovery from anesthesia [28]. During the last decade, clinical use of sevoflurane has been spreading in veterinary species such as horses [3,14,24,31], cats [15] and dogs [1,2]. Sevoflurane is minimally metabolized and easily cleared in animals; however, it should be remembered that sevoflurane causes dose-dependent hypotension, hypoventilation, impaired cardiac contractility and hypothermia [21]. Because of these side effects, sevoflurane must be carefully titrated, and vigilant monitoring should be employed to avoid excessive anesthetic depth.MAC has been defined as "the minimum alveolar concentration of anesthetic at 1 atmosphere that produces immobility in 50% of those animals exposed to a noxious stimulus" [5]. It has long been known that MAC decreases with age in humans [8,20,22,26,29]. In human medicine, anesthetists can rapidly determine the depth of anesthesia in age-corrected MAC units for volatile anesthetics by using a normogram to estimate age-related MAC [16] and agerelated iso-MAC charts [23]. In the recent practice of veterinary anesthesia, geriatric animals have become a significant proportion of the patient population. Attention to the unique physiology and particular requirements of individuals within this age group will contribute to the provision of safe and effective anesthesia [9,19]. Veterinary practitioners believe that geriatric animals require a lower concentration of inhalation anesthetic to maintain anesthesia based on clinical experience. To the best of our knowledge, however, there are few reports on the relationship of MAC to age in veterinary species [11,17]. Furthermore, the relationship of sevoflurane MAC to age has not been evaluated in dogs. The purpose of the study reported here was to determine the effect of age on sevoflurane MAC in dogs. The authors hypothesized that the sevoflurane MAC value would be inversely related to age in this species.Six young beagles, 2 years of age (all male) and weighing from 9.7 to 11.8 kg (10.8  0.9 kg of mean  SD), and six old beagles, 8 to...

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A multisite case report on the clinical use of sevoflurane in dogs

Cited by 18 publications

References 19 publications

Intracranial variables in propofol or sevoflurane-anesthestized dogs subjected to subarachnoid administration of iohexol

Intracranial variables in propofol or sevoflurane-anesthestized dogs subjected to subarachnoid administration of iohexol

Minimum Alveolar Concentration for Blunting Adrenergic Responses (MAC-BAR) of Sevoflurane in Dogs

Effect of Age on Minimum Alveolar Concentration (MAC) of Sevoflurane in Dogs

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