A Multisite Canadian Study of Outcome of First-Episode Psychosis Treated in Publicly Funded Early Intervention Services

Malla, Ashok; Schmitz, N.; Norman, Ross; Archie, Suzanne; Windell, Deborah; Roy, Paul; Zipursky, Robert B.

doi:10.1177/070674370705200904

Cited by 45 publications

(53 citation statements)

References 31 publications

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“…A total of 402 papers were identified by the search strategy, from which we identified 28 non-overlapping first episode studies that met inclusion criteria (see Appendix 1) (Montague et al, 1989;Barnes et al, 2000;Craig et al, 2000;de Haan et al, 2000;Drake et al, 2000;Ho et al, 2000;Larsen et al, 2000;Black et al, 2001;Verdoux et al, 2001;Cullberg et al, 2002;Malla et al, 2003;Addington et al, 2004;Sim et al, 2004;Chen et al, 2005;Harris et al, 2005;Manchanda et al, 2005;Melle et al, 2005;Oosthuizen et al, 2005;Petersen et al, 2005;Wade et al, 2005;Clarke et al, 2006;Ucok et al, 2006;Wunderink et al, 2006;Crespo-Facorro et al, 2007;Malla et al, 2007;Vyas et al, 2007;Gorna et al, 2008;Yamazawa et al, 2008). The selected studies included a total of 3998 participants.…”

Section: Studies and Patientsmentioning

confidence: 99%

“…Table 1 shows the distribution of DUP, gender and age at onset of participants of whom individual patient data were available at baseline. The follow-up data of 2 studies were incomplete and therefore only baseline data were used in our analysis (Montague et al, 1989;Malla et al, 2003;Melle et al, 2004;Manchanda et al, 2005;Malla et al, 2007).…”

Section: Studies and Patientsmentioning

confidence: 99%

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Duration of untreated psychosis and negative symptoms — A systematic review and meta-analysis of individual patient data

Boonstra

Klaassen

Sytema

et al. 2012

Schizophrenia Research

204

134

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Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Background: Longer duration of untreated psychosis (DUP) is associated with poorer outcome in terms of positive symptoms, relapse rate, and time to remission. In contrast, the association with negative symptoms is less consistent. Aims: The study had three aims. First, to arrive at a more precise estimate of the correlation between DUP and negative symptoms than previous reviews, by substantially increasing the amount of available data. Second, to see whether the strength of this correlation attenuated over longer follow-up intervals. Third, to determine whether there is a relationship between DUP and changes in negative symptoms. Method: Relevant databases were searched for studies published between December 1992 and March 2009 that reported data on DUP and negative symptoms. We obtained individual patient data where possible and calculated summary correlations between DUP and negative symptoms for each study at baseline, short and long-term follow-up. We used multilevel regression analysis to examine whether the effect of DUP on negative symptoms was the greatest in the early stages of illness. Results: We included 28 non-overlapping studies from the 402 papers detected by the search strategy. After contacting the authors we obtained individual patient data from 16 of these studies involving 3339 participants. The mean DUP was 61.4 weeks (SD = 132.7, median DUP = 12.0). Shorter DUP was significantly associated with less severe negative symptoms at baseline and also at short (1-2 years) and longer term follow-up (5-8 years) (r = 0.117, 0.180 and 0.202 respectively, p b 0.001). The relationship between improvement in negative symptoms and DUP was found to be non-linear: people with a DUP shorter than 9 months showed substantially greater negative symptom reduction than those with a DUP of greater than 9 months. Conclusions: Shorter DUP is associated with less severe negative symptoms at short and long-term follow up, especially when the DUP is less than 9 months. Since there is no effective treatment for negative symptoms, reducing DUP to less than 9 months may be the best way to ameliorate them.

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Section: Studies and Patientsmentioning

confidence: 99%

Section: Studies and Patientsmentioning

confidence: 99%

Duration of untreated psychosis and negative symptoms — A systematic review and meta-analysis of individual patient data

Boonstra

Klaassen

Sytema

et al. 2012

Schizophrenia Research

204

134

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“…8,9 Such projects have demonstrated a positive impact upon help seeking by raising awareness of psychosis and sources of help through educational information campaigns targeted at the general population, schools and general practitioners (GPs). [9][10][11] With FEP typically experienced during early adulthood and an estimated 60-70% of individuals living within the family home, 12 family members often play a vital role in seeking help on behalf of their loved ones. 13,14 Contradictory findings have been reported regarding the relationship between family involvement (defined as where at least one family member is actively involved in seeking help for the individual) and help seeking.…”

Section: Introductionmentioning

confidence: 99%

Family members' experience of seeking help for first‐episode psychosis on behalf of a loved one: a meta‐synthesis of qualitative research

Cairns

Reid

Murray

2014

Early Intervention Psych

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The findings provide a novel insight into this experience, suggesting implications for clinical practice. These include a focus upon the facilitation of early positive interactions with family members and for first-episode psychosis to be presented to families in a normalizing manner. The need for future research that examines the experience of those who do not seek help from health services is discussed.

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“…[2][3][4][5] In Canada, several studies have tried to understand better the social-cultural and systems of care factors as well as the systems of care delivery that shape access to care. [18][19][20] These have focused on ethnicity. [19][20][21][22] Along with ethnicity, gender is a critical demographic determinant in schizophrenia and first-episode psychosis research.…”

Section: Introductionmentioning

confidence: 99%

Gender differences in pathways to care for early psychosis

Ferrari

Flora

Anderson

et al. 2016

Early Intervention Psych

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A Multisite Canadian Study of Outcome of First-Episode Psychosis Treated in Publicly Funded Early Intervention Services

Abstract: Similarly enriched EI services may produce different outcomes, even within a relatively homogeneous mental health system.

Cited by 45 publications

References 31 publications

Duration of untreated psychosis and negative symptoms — A systematic review and meta-analysis of individual patient data

Duration of untreated psychosis and negative symptoms — A systematic review and meta-analysis of individual patient data

Family members' experience of seeking help for first‐episode psychosis on behalf of a loved one: a meta‐synthesis of qualitative research

Gender differences in pathways to care for early psychosis

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